CDYL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDYL2_HUMAN
• UniProt AC: Q8N8U2
• Protein Name: Chromodomain Y-like protein 2
• Gene Name: CDYL2
• Organism: Homo sapiens (Human).
• Sequence Length: 506
• Subcellular Localization: Nucleus.
• Protein Sequence: MASGDLYEVERIVDKRKNKKGKWEYLIRWKGYGSTEDTWEPEHHLLHCEEFIDEFNGLHMSKDKRIKSGKQSSTSKLLRDSRGPSVEKLSHRPSDPGKSKGTSHKRKRINPPLAKPKKGYSGKPSSGGDRATKTVSYRTTPSGLQIMPLKKSQNGMENGDAGSEKDERHFGNGSHQPGLDLNDHVGEQDMGECDVNHATLAENGLGSALTNGGLNLHSPVKRKLEAEKDYVFDKRLRYSVRQNESNCRFRDIVVRKEEGFTHILLSSQTSDNNALTPEIMKEVRRALCNAATDDSKLLLLSAVGSVFCSGLDYSYLIGRLSSDRRKESTRIAEAIRDFVKAFIQFKKPIVVAINGPALGLGASILPLCDIVWASEKAWFQTPYATIRLTPAGCSSYTFPQILGVALANEMLFCGRKLTAQEACSRGLVSQVFWPTTFSQEVMLRVKEMASCSAVVLEESKCLVRSFLKSVLEDVNEKECLMLKQLWSSSKGLDSLFSYLQDKIYEV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASGDLYEVE -----CCCCCCEEEE	31.38	20860994
25	Phosphorylation	NKKGKWEYLIRWKGY CCCCCEEEEEEEECC	13.30	20068231
81	Phosphorylation	TSKLLRDSRGPSVEK HHHHHHCCCCCCHHH	32.47	25159151
85	O-linked_Glycosylation	LRDSRGPSVEKLSHR HHCCCCCCHHHHCCC	45.81	30379171
85	Phosphorylation	LRDSRGPSVEKLSHR HHCCCCCCHHHHCCC	45.81	25159151
88	Ubiquitination	SRGPSVEKLSHRPSD CCCCCHHHHCCCCCC	53.81	29967540
94	Phosphorylation	EKLSHRPSDPGKSKG HHHCCCCCCCCCCCC	57.29	25159151
120	Phosphorylation	LAKPKKGYSGKPSSG CCCCCCCCCCCCCCC	24.11	21712546
121	Phosphorylation	AKPKKGYSGKPSSGG CCCCCCCCCCCCCCC	49.35	21712546
132	Phosphorylation	SSGGDRATKTVSYRT CCCCCCCEEEEEEEE	28.30	28634298
133	Methylation	SGGDRATKTVSYRTT CCCCCCEEEEEEEEC	46.04	-
134	Phosphorylation	GGDRATKTVSYRTTP CCCCCEEEEEEEECC	15.44	29632367
136	Phosphorylation	DRATKTVSYRTTPSG CCCEEEEEEEECCCC	17.71	28634298
137	Phosphorylation	RATKTVSYRTTPSGL CCEEEEEEEECCCCC	13.98	29632367
139	Phosphorylation	TKTVSYRTTPSGLQI EEEEEEEECCCCCEE	34.52	29632367
140	Phosphorylation	KTVSYRTTPSGLQIM EEEEEEECCCCCEEE	13.37	21815630
142	Phosphorylation	VSYRTTPSGLQIMPL EEEEECCCCCEEEEC	50.47	29632367
152	Phosphorylation	QIMPLKKSQNGMENG EEEECCCCCCCCCCC	27.56	29632367
163	Phosphorylation	MENGDAGSEKDERHF CCCCCCCCCCCCCCC	43.10	21815630
228	Ubiquitination	KRKLEAEKDYVFDKR HHHHHHHHHHHHCHH	62.50	29967540
228	Acetylation	KRKLEAEKDYVFDKR HHHHHHHHHHHHCHH	62.50	26051181
234	Ubiquitination	EKDYVFDKRLRYSVR HHHHHHCHHHHHHHH	41.70	29967540
234	Acetylation	EKDYVFDKRLRYSVR HHHHHHCHHHHHHHH	41.70	26051181
239	Phosphorylation	FDKRLRYSVRQNESN HCHHHHHHHHCCCCC	12.37	20860994
256	Acetylation	FRDIVVRKEEGFTHI EEEEEEEECCCCEEE	48.81	26051181
281	Ubiquitination	ALTPEIMKEVRRALC CCCHHHHHHHHHHHH	59.73	29967540
328	Phosphorylation	SSDRRKESTRIAEAI CCHHHHHHHHHHHHH	26.48	26437602
329	Phosphorylation	SDRRKESTRIAEAIR CHHHHHHHHHHHHHH	27.47	-
374	Phosphorylation	LCDIVWASEKAWFQT HHHHHHHCCCCCCCC	24.74	24719451
416	Acetylation	EMLFCGRKLTAQEAC CHHHCCCCCHHHHHH	35.16	26051181
446	Ubiquitination	QEVMLRVKEMASCSA HHHHHHHHHHHCCEE	35.03	29967540
465	Phosphorylation	ESKCLVRSFLKSVLE HHHHHHHHHHHHHHH	27.70	24719451
468	Ubiquitination	CLVRSFLKSVLEDVN HHHHHHHHHHHHHCC	36.19	29967540
477	Acetylation	VLEDVNEKECLMLKQ HHHHCCHHHHHHHHH	48.82	26051181
490	Acetylation	KQLWSSSKGLDSLFS HHHHHCCCCHHHHHH	66.49	26051181
494	Phosphorylation	SSSKGLDSLFSYLQD HCCCCHHHHHHHHHH	36.03	27499020

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDYL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDYL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDYL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM5_HUMAN	PRMT5	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.