HXK2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXK2_RAT
• UniProt AC: P27881
• Protein Name: Hexokinase-2
• Gene Name: Hk2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 917
• Protein Sequence: MIASHMIACLFTELNQNQVQKVDQFLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEEDKDGIEKAYQILMRLGLNPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIASHMIA -------CHHHHHHH	5.36	-
312	Acetylation	LVRLILVKMAKAELL HHHHHHHHHHHHHHH	29.69	-
398	Acetylation	AAVLWRIKENKGEER HHHHHHHHHCCCHHH	46.81	22902405
418	Acetylation	GVDGSVYKKHPHFAK CCCCCHHHHCHHHHH	42.31	22902405
445	Phosphorylation	CDVRFLRSEDGSGKG CCEEEEECCCCCCHH	42.03	26022182
449	Phosphorylation	FLRSEDGSGKGAAMV EEECCCCCCHHHHHH	50.05	26022182
461	Phosphorylation	AMVTAVAYRLADQHR HHHHHHHHHHHHHHH	10.28	22817900
749	Phosphorylation	EKMISGMYLGEIVRN HHHHCHHHHHHHHHH	18.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXK2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXK2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXK2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTGDS_HUMAN	PTGDS	physical	11068878
IBP4_HUMAN	IGFBP4	physical	11068878
ZBT17_HUMAN	ZBTB17	physical	11068878

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.