IBP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IBP4_HUMAN
• UniProt AC: P22692
• Protein Name: Insulin-like growth factor-binding protein 4
• Gene Name: IGFBP4
• Organism: Homo sapiens (Human).
• Sequence Length: 258
• Subcellular Localization: Secreted.
• Protein Description: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors..
• Protein Sequence: MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	AIHCPPCSEEKLARC CCCCCCCCHHHHHCC	55.34	24505115
112	Phosphorylation	EIEAIQESLQPSDKD HHHHHHHHCCCCCCC	18.87	26091039
125	N-linked_Glycosylation	KDEGDHPNNSFSPCS CCCCCCCCCCCCCCH	54.05	1709161
129	Phosphorylation	DHPNNSFSPCSAHDR CCCCCCCCCCHHHHH	25.47	26091039
150	Phosphorylation	FAKIRDRSTSGGKMK HHHHHHCCCCCCCEE	31.08	29396449
151	Phosphorylation	AKIRDRSTSGGKMKV HHHHHCCCCCCCEEE	32.08	29396449
152	Phosphorylation	KIRDRSTSGGKMKVN HHHHCCCCCCCEEEC	46.96	29396449
155	Ubiquitination	DRSTSGGKMKVNGAP HCCCCCCCEEECCCC	38.79	-
173	O-linked_Glycosylation	ARPVPQGSCQSELHR CCCCCCCCHHHHHHH	12.07	55829379
192	O-linked_Glycosylation	LAASQSRTHEDLYII HHHCCCCCCCCEEEE	34.56	OGP
197	Phosphorylation	SRTHEDLYIIPIPNC CCCCCCEEEEECCCC	14.77	27642862
255	Phosphorylation	DCHQLADSFRE---- CHHHHHHHHCC----	22.16	1709161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
255	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IBP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IBP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGF1_HUMAN	IGF1	physical	9722589
IGF2_HUMAN	IGF2	physical	9722589
HXK2_RAT	Hk2	physical	11068878
HXK3_RAT	Hk3	physical	11068878
KDM1A_HUMAN	KDM1A	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.