dbPTM

UBXN6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBXN6_HUMAN
UniProt AC	Q9BZV1
Protein Name	UBX domain-containing protein 6 {ECO:0000305}
Gene Name	UBXN6 {ECO:0000312\|HGNC:HGNC:14928}
Organism	Homo sapiens (Human).
Sequence Length	441
Subcellular Localization	Cytoplasm . Cytoplasm, cytosol . Membrane Peripheral membrane protein . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Early endosome membrane Peripheral membrane protein . Late endosome membrane Peripheral membrane p
Protein Description	May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. [PubMed: 26475856 As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation]
Protein Sequence	MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPPRQGPTNEAQMAAAAALARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAPGTNVVSEPREEGSAHLAVPGVYFTCPLTGATLRKDQRDACIKEAILLHFSTDPVAASIMKIYTFNKDQDRVKLGVDTIAKYLDNIHLHPEEEKYRKIKLQNKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFYVLSETTLAQPQSLERHKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEIKREQRLRSEAVERLSVLRTKAMREKEEQRGLRKYNYTLLRVRLPDGCLLQGTFYARERLGAVYGFVREALQSDWLPFELLASGGQKLSEDENLALNECGLVPSALLTFSWDMAVLEDIKAAGAEPDSILKPELLSAIEKLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKKFFQEFK ------CHHHHHHHH	59.28	23000965
3	Ubiquitination	-----MKKFFQEFKA -----CHHHHHHHHH	50.54	23000965
9	Ubiquitination	KKFFQEFKADIKFKS HHHHHHHHHCCCEEC	44.38	23000965
13	Ubiquitination	QEFKADIKFKSAGPG HHHHHCCCEECCCCC	47.49	27667366
15	Ubiquitination	FKADIKFKSAGPGQK HHHCCCEECCCCCHH	34.10	27667366
22	Ubiquitination	KSAGPGQKLKESVGE ECCCCCHHHHHHHHH	68.40	27667366
24	Sumoylation	AGPGQKLKESVGEKA CCCCHHHHHHHHHHH	55.78	-
24	Ubiquitination	AGPGQKLKESVGEKA CCCCHHHHHHHHHHH	55.78	29967540
24	Sumoylation	AGPGQKLKESVGEKA CCCCHHHHHHHHHHH	55.78	-
26	Phosphorylation	PGQKLKESVGEKAHK CCHHHHHHHHHHHHH	33.56	28857561
30	Ubiquitination	LKESVGEKAHKEKPN HHHHHHHHHHHCCCC	50.27	33845483
32 (in isoform 2)	Ubiquitination	-	50.29	21906983
32	Ubiquitination	ESVGEKAHKEKPNQP HHHHHHHHHCCCCCC	50.29	21963094
35	Ubiquitination	GEKAHKEKPNQPAPR HHHHHHCCCCCCCCC	54.81	27667366
66	Ubiquitination	ALARLEQKQSRAWGP HHHHHHHHHHHHCCC	40.65	27667366
68	Phosphorylation	ARLEQKQSRAWGPTS HHHHHHHHHHCCCCC	30.88	-
69	Ubiquitination	RLEQKQSRAWGPTSQ HHHHHHHHHCCCCCH	31.68	27667366
75	Phosphorylation	SRAWGPTSQDTIRNQ HHHCCCCCHHHHHHH	29.23	28857561
78	Phosphorylation	WGPTSQDTIRNQVRK CCCCCHHHHHHHHHH	17.75	28857561
85 (in isoform 1)	Ubiquitination	-	65.01	21906983
85	Ubiquitination	TIRNQVRKELQAEAT HHHHHHHHHHHHHEE	65.01	21906983
92	Phosphorylation	KELQAEATVSGSPEA HHHHHHEEECCCCCC	13.50	30266825
94	Phosphorylation	LQAEATVSGSPEAPG HHHHEEECCCCCCCC	29.24	30266825
96	Phosphorylation	AEATVSGSPEAPGTN HHEEECCCCCCCCCC	16.44	30266825
100	Ubiquitination	VSGSPEAPGTNVVSE ECCCCCCCCCCCCCC	48.78	27667366
102	Phosphorylation	GSPEAPGTNVVSEPR CCCCCCCCCCCCCCC	24.63	30266825
106	Phosphorylation	APGTNVVSEPREEGS CCCCCCCCCCCCCCC	37.29	26699800
113	Phosphorylation	SEPREEGSAHLAVPG CCCCCCCCCCEECCC	18.78	26657352
113	Ubiquitination	SEPREEGSAHLAVPG CCCCCCCCCCEECCC	18.78	27667366
119	Ubiquitination	GSAHLAVPGVYFTCP CCCCEECCCEEEECC	22.41	21963094
119 (in isoform 2)	Ubiquitination	-	22.41	21906983
122	Phosphorylation	HLAVPGVYFTCPLTG CEECCCEEEECCCCC	10.09	27642862
127	Ubiquitination	GVYFTCPLTGATLRK CEEEECCCCCCCCCH	8.20	21963094
127 (in isoform 2)	Ubiquitination	-	8.20	21906983
128	Phosphorylation	VYFTCPLTGATLRKD EEEECCCCCCCCCHH	15.20	24076635
131	Phosphorylation	TCPLTGATLRKDQRD ECCCCCCCCCHHHHH	28.57	28857561
140	Ubiquitination	RKDQRDACIKEAILL CHHHHHHHHHHHHHH	5.52	30230243
145	Ubiquitination	DACIKEAILLHFSTD HHHHHHHHHHHCCCC	4.39	22817900
149	Ubiquitination	KEAILLHFSTDPVAA HHHHHHHCCCCHHHH	9.43	30230243
149 (in isoform 2)	Ubiquitination	-	9.43	21906983
166	Malonylation	MKIYTFNKDQDRVKL HHHEECCCCHHHHEC	53.20	26320211
166	Ubiquitination	MKIYTFNKDQDRVKL HHHEECCCCHHHHEC	53.20	27667366
172	Ubiquitination	NKDQDRVKLGVDTIA CCCHHHHECCHHHHH	40.18	21906983
172 (in isoform 1)	Ubiquitination	-	40.18	21906983
177	Phosphorylation	RVKLGVDTIAKYLDN HHECCHHHHHHHHHH	22.04	28857561
180	Ubiquitination	LGVDTIAKYLDNIHL CCHHHHHHHHHHCCC	42.36	21906983
180 (in isoform 1)	Ubiquitination	-	42.36	21906983
181	Phosphorylation	GVDTIAKYLDNIHLH CHHHHHHHHHHCCCC	15.40	29496907
193	Ubiquitination	HLHPEEEKYRKIKLQ CCCHHHHHHHHHHHH	54.35	30230243
194	Phosphorylation	LHPEEEKYRKIKLQN CCHHHHHHHHHHHHH	22.03	27642862
196	Ubiquitination	PEEEKYRKIKLQNKV HHHHHHHHHHHHHHH	40.89	-
198	Ubiquitination	EEKYRKIKLQNKVFQ HHHHHHHHHHHHHHH	47.24	22817900
200	Ubiquitination	KYRKIKLQNKVFQER HHHHHHHHHHHHHHH	42.57	22505724
202 (in isoform 1)	Ubiquitination	-	31.31	21906983
202	Ubiquitination	RKIKLQNKVFQERIN HHHHHHHHHHHHHHH	31.31	21906983
204	Ubiquitination	IKLQNKVFQERINCL HHHHHHHHHHHHHCH	7.15	22505724
206	Ubiquitination	LQNKVFQERINCLEG HHHHHHHHHHHCHHC	44.02	21963094
214	Ubiquitination	RINCLEGTHEFFEAI HHHCHHCHHHHHHHH	14.62	21963094
216	Ubiquitination	NCLEGTHEFFEAIGF HCHHCHHHHHHHHCC	52.44	29967540
232	Ubiquitination	KVLLPAQDQEDPEEF EEEEECCCCCCHHHE	56.81	22817900
236	Ubiquitination	PAQDQEDPEEFYVLS ECCCCCCHHHEEEEE	42.11	22817900
240	Phosphorylation	QEDPEEFYVLSETTL CCCHHHEEEEEECCC	12.08	25693802
243	Phosphorylation	PEEFYVLSETTLAQP HHHEEEEEECCCCCC	23.89	30622161
245	Phosphorylation	EFYVLSETTLAQPQS HEEEEEECCCCCCCC	24.59	30622161
246	Phosphorylation	FYVLSETTLAQPQSL EEEEEECCCCCCCCH	18.95	30622161
248	Ubiquitination	VLSETTLAQPQSLER EEEECCCCCCCCHHH	19.54	22817900
248 (in isoform 2)	Ubiquitination	-	19.54	21906983
252	Phosphorylation	TTLAQPQSLERHKEQ CCCCCCCCHHHHHHH	38.59	27470641
257	Ubiquitination	PQSLERHKEQLLAAE CCCHHHHHHHHHHHH	54.07	22505724
269	Ubiquitination	AAEPVRAKLDRQRRV HHHHHHHHHHHCCCC	40.11	29967540
272	Ubiquitination	PVRAKLDRQRRVFQP HHHHHHHHCCCCCCC	42.20	29967540
280	Phosphorylation	QRRVFQPSPLASQFE CCCCCCCCCCHHHCC	23.05	30622161
284	Phosphorylation	FQPSPLASQFELPGD CCCCCCHHHCCCCCC	42.98	30622161
291	Ubiquitination	SQFELPGDFFNLTAE HHCCCCCCHHCCCHH	42.92	22505724
301 (in isoform 1)	Ubiquitination	-	53.84	21906983
301	Ubiquitination	NLTAEEIKREQRLRS CCCHHHHHHHHHHHH	53.84	21906983
308	Phosphorylation	KREQRLRSEAVERLS HHHHHHHHHHHHHHH	34.20	28555341
315	Phosphorylation	SEAVERLSVLRTKAM HHHHHHHHHHHHHHH	25.90	28555341
325	Ubiquitination	RTKAMREKEEQRGLR HHHHHHHHHHHHCHH	57.07	29967540
333	Malonylation	EEQRGLRKYNYTLLR HHHHCHHHCCEEEEE	42.78	26320211
333	Ubiquitination	EEQRGLRKYNYTLLR HHHHCHHHCCEEEEE	42.78	-
335	Ubiquitination	QRGLRKYNYTLLRVR HHCHHHCCEEEEEEE	26.75	22817900
336	Phosphorylation	RGLRKYNYTLLRVRL HCHHHCCEEEEEEEC	8.82	20090780
337	Phosphorylation	GLRKYNYTLLRVRLP CHHHCCEEEEEEECC	18.71	28152594
352	Phosphorylation	DGCLLQGTFYARERL CCCEEEEEEEHHHHH	10.66	28152594
354	Phosphorylation	CLLQGTFYARERLGA CEEEEEEEHHHHHHH	12.46	28152594
363	Phosphorylation	RERLGAVYGFVREAL HHHHHHHHHHHHHHH	12.33	28152594
377	Ubiquitination	LQSDWLPFELLASGG HHCCCCCHHHHHCCC	10.94	22817900
377 (in isoform 2)	Ubiquitination	-	10.94	21906983
386	Ubiquitination	LLASGGQKLSEDENL HHHCCCCCCCCCCCC	58.20	29967540
427	Phosphorylation	AAGAEPDSILKPELL HCCCCCCCCCCHHHH	40.30	24719451
430 (in isoform 1)	Ubiquitination	-	34.47	21906983
430	Ubiquitination	AEPDSILKPELLSAI CCCCCCCCHHHHHHH	34.47	22817900
439	Ubiquitination	ELLSAIEKLL----- HHHHHHHHHC-----	49.31	29967540
464	Ubiquitination	------------------------------ ------------------------------		22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBXN6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBXN6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_HUMAN	VCP	physical	19174149
TERA_HUMAN	VCP	physical	21896481
TERA_HUMAN	VCP	physical	18775313
PPB1_HUMAN	ALPP	physical	18775313
VCIP1_HUMAN	VCPIP1	physical	18775313
TERA_HUMAN	VCP	physical	16807242
TERA_HUMAN	VCP	physical	19275885
DERL1_HUMAN	DERL1	physical	19275885
PSMD2_HUMAN	PSMD2	physical	18656546
TERA_HUMAN	VCP	physical	22350894
LMAN1_HUMAN	LMAN1	physical	22337587
TERA_HUMAN	VCP	physical	22337587
LIMA1_HUMAN	LIMA1	physical	22337587
SEPT9_HUMAN	SEPT9	physical	22337587
DYST_HUMAN	DST	physical	22337587
TBA1C_HUMAN	TUBA1C	physical	22337587
RUVB2_HUMAN	RUVBL2	physical	22337587
ASPC1_HUMAN	ASPSCR1	physical	22337587
FAF2_HUMAN	FAF2	physical	22337587
UGGG1_HUMAN	UGGT1	physical	22337587
EF1A2_HUMAN	EEF1A2	physical	22337587
TBB6_HUMAN	TUBB6	physical	22337587
RUVB1_HUMAN	RUVBL1	physical	22337587
RS3_HUMAN	RPS3	physical	22337587
PRKDC_HUMAN	PRKDC	physical	22337587
TCPQ_HUMAN	CCT8	physical	22337587
IRS4_HUMAN	IRS4	physical	22337587
NPL4_HUMAN	NPLOC4	physical	22337587
CALX_HUMAN	CANX	physical	22337587
FLOT1_HUMAN	FLOT1	physical	22337587
HNRPU_HUMAN	HNRNPU	physical	22337587
MCFD2_HUMAN	MCFD2	physical	22337587
COPA_HUMAN	COPA	physical	22337587
A4_HUMAN	APP	physical	21832049
VPS39_HUMAN	VPS39	physical	22939629
Z3H7B_HUMAN	ZC3H7B	physical	22939629
XPO6_HUMAN	XPO6	physical	22939629
TERA_HUMAN	VCP	physical	26186194
NCPR_HUMAN	POR	physical	26186194
MT21D_HUMAN	VCPKMT	physical	26186194
UBX2A_HUMAN	UBXN2A	physical	26186194
ASPC1_HUMAN	ASPSCR1	physical	26186194
F104A_HUMAN	FAM104A	physical	26186194
TERA_HUMAN	VCP	physical	26475856
TERA_HUMAN	VCP	physical	26389662
NSF1C_HUMAN	NSFL1C	physical	26389662
ARAF_HUMAN	ARAF	physical	26389662
ACTBL_HUMAN	ACTBL2	physical	26389662
NCPR_HUMAN	POR	physical	26389662
ASPC1_HUMAN	ASPSCR1	physical	26389662
TERA_HUMAN	VCP	physical	27913212
MT21D_HUMAN	VCPKMT	physical	28514442
TERA_HUMAN	VCP	physical	28514442
F104A_HUMAN	FAM104A	physical	28514442
UBX2A_HUMAN	UBXN2A	physical	28514442
NCPR_HUMAN	POR	physical	28514442
ASPC1_HUMAN	ASPSCR1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBXN6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-336, AND MASSSPECTROMETRY.	18083107 [Abstract]