F104A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F104A_HUMAN
• UniProt AC: Q969W3
• Protein Name: Protein FAM104A
• Gene Name: FAM104A
• Organism: Homo sapiens (Human).
• Sequence Length: 186
• Protein Sequence: MGGRGADAGSSGGTGPTEGYSPPAASTRAAARAKARGGGRGGRRNTTPSVPSLRGAAPRSFHPPAAMSERLRPRKRRRNGNEEDNHLPPQTKRSSRNPVFQDSWDTESSGSDSGGSSSSSSSSINSPDRASGPEGSLSQTMAGSSPNTPQPVPEQSALCQGLYFHINQTLREAHFHSLQHRGRPLT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MGGRGADAGSS ----CCCCCCCCCCC	31.25	24129315
10	Phosphorylation	GRGADAGSSGGTGPT CCCCCCCCCCCCCCC	27.77	29255136
11	Phosphorylation	RGADAGSSGGTGPTE CCCCCCCCCCCCCCC	40.08	29255136
14	Phosphorylation	DAGSSGGTGPTEGYS CCCCCCCCCCCCCCC	43.44	29255136
17	Phosphorylation	SSGGTGPTEGYSPPA CCCCCCCCCCCCCCH	43.30	30266825
20	Phosphorylation	GTGPTEGYSPPAAST CCCCCCCCCCCHHHH	16.27	26657352
21	Phosphorylation	TGPTEGYSPPAASTR CCCCCCCCCCHHHHH	34.95	23401153
21 (in isoform 2)	Phosphorylation	-	34.95	24719451
26	Phosphorylation	GYSPPAASTRAAARA CCCCCHHHHHHHHHH	22.11	29255136
27	Phosphorylation	YSPPAASTRAAARAK CCCCHHHHHHHHHHH	21.43	29255136
28	Methylation	SPPAASTRAAARAKA CCCHHHHHHHHHHHH	21.52	-
46 (in isoform 2)	Phosphorylation	-	37.97	24719451
46	Phosphorylation	GRGGRRNTTPSVPSL CCCCCCCCCCCCCCC	37.97	24719451
47	Phosphorylation	RGGRRNTTPSVPSLR CCCCCCCCCCCCCCC	19.67	27251275
52	Phosphorylation	NTTPSVPSLRGAAPR CCCCCCCCCCCCCCC	28.66	24719451
54	Methylation	TPSVPSLRGAAPRSF CCCCCCCCCCCCCCC	36.72	-
68	Phosphorylation	FHPPAAMSERLRPRK CCCCHHHHHHHCCCH	18.16	28555341
108	Phosphorylation	QDSWDTESSGSDSGG CCCCCCCCCCCCCCC	41.93	19369195
126	Phosphorylation	SSSSSINSPDRASGP CCCCCCCCCCCCCCC	26.89	28985074
129 (in isoform 2)	Phosphorylation	-	33.75	-
132 (in isoform 2)	Phosphorylation	-	24.24	28348404
134 (in isoform 2)	Phosphorylation	-	66.01	28348404
137 (in isoform 2)	Phosphorylation	-	6.90	28348404
138 (in isoform 2)	Phosphorylation	-	25.88	28348404
139 (in isoform 2)	Phosphorylation	-	40.36	28348404
140 (in isoform 2)	Phosphorylation	-	12.95	28348404
144	Phosphorylation	LSQTMAGSSPNTPQP CHHHHCCCCCCCCCC	32.84	26074081
144 (in isoform 2)	Phosphorylation	-	32.84	27251275
145	Phosphorylation	SQTMAGSSPNTPQPV HHHHCCCCCCCCCCC	22.66	26074081
147 (in isoform 2)	Phosphorylation	-	67.36	28674419
148	Phosphorylation	MAGSSPNTPQPVPEQ HCCCCCCCCCCCCCH	27.04	26074081
166 (in isoform 2)	Phosphorylation	-	2.68	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F104A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F104A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F104A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSF1C_HUMAN	NSFL1C	physical	26389662

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-108, AND MASSSPECTROMETRY.
PubMed: 19369195