dbPTM

C19L2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	C19L2_HUMAN
UniProt AC	Q2TBE0
Protein Name	CWF19-like protein 2
Gene Name	CWF19L2
Organism	Homo sapiens (Human).
Sequence Length	894
Subcellular Localization
Protein Description
Protein Sequence	MATSMAAASGRFESAKSIEERKEQTRNARAEVLRQAKANFEKEERRKELKRLRGEDTWMLPDVNERIEQFSQEHSVKKKKKKDKHSKKAKKEKKKKSKKQKYEKNNESSDSSSSSEDEWVEAVPSQTPDKEKAWKVKDEKSGKDDTQIIKRDEWMTVDFMSVKTVSSSSLKAEKETMRKIEQEKNQALEQSKLMERELNPYWKDGGTGLPPEDCSVSSITKVSVVEDGGLSWLRKSYLRMKEQAEKQSRNFEDIVAERYGSMEIFQSKLEDAEKAASTKEDYRRERWRKPTYSDKAQNCQESRESDLVKYGNSSRDRYATTDTAKNSNNEKFIGDEKDKRPGSLETCRRESNPRQNQEFSFGNLRAKFLRPSDDEELSFHSKGRKFEPLSSSSALVAQGSLCSGFRKPTKNSEERLTSWSRSDGRGDKKHSNQKPSETSTDEHQHVPEDPREKSQDEVLRDDPPKKEHLRDTKSTFAGSPERESIHILSVDEKNKLGAKIIKAEMMGNMELAEQLKVQLEKANKFKETITQIPKKSGVENEDQQEVILVRTDQSGRVWPVNTPGKSLESQGGRRKRQMVSTHEERERVRYFHDDDNLSLNDLVKNEKMGTAENQNKLFMRMASKFMGKTDGDYYTLDDMFVSKAAERERLGEEEENQRKKAIAEHRSLAAQMEKCLYCFDSSQFPKHLIVAIGVKVYLCLPNVRSLTEGHCLIVPLQHHRAATLLDEDIWEEIQMFRKSLVKMFEDKGLDCIFLETNMSMKKQYHMVYECIPLPKEVGDMAPIYFKKAIMESDEEWSMNKKLIDLSSKDIRKSVPRGLPYFSVDFGLHGGFAHVIEDQHKFPHYFGKEIIGGMLDIEPRLWRKGIRESFEDQRKKALQFAQWWKPYDFTKSKNY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ATSMAAASGRFESAK CCHHHHHHCCCHHHH	26.27	-
16	Acetylation	SGRFESAKSIEERKE HCCCHHHHHHHHHHH	62.33	25953088
17	Phosphorylation	GRFESAKSIEERKEQ CCCHHHHHHHHHHHH	34.64	26091039
34	Methylation	NARAEVLRQAKANFE HHHHHHHHHHHHHCC	39.32	-
37	Ubiquitination	AEVLRQAKANFEKEE HHHHHHHHHHCCHHH	35.21	29967540
71	Phosphorylation	NERIEQFSQEHSVKK HHHHHHHHHHHHHHH	34.06	20068231
75	Phosphorylation	EQFSQEHSVKKKKKK HHHHHHHHHHHHHHH	34.57	25159151
102	Phosphorylation	KKSKKQKYEKNNESS HHHHHHHHHHCCCCC	29.64	27134283
108	Phosphorylation	KYEKNNESSDSSSSS HHHHCCCCCCCCCCC	41.38	30576142
109	Phosphorylation	YEKNNESSDSSSSSE HHHCCCCCCCCCCCH	35.02	30576142
115	Phosphorylation	SSDSSSSSEDEWVEA CCCCCCCCHHHHHHC	51.52	-
127	Phosphorylation	VEAVPSQTPDKEKAW HHCCCCCCCCHHHCC	37.48	27134283
161	Phosphorylation	WMTVDFMSVKTVSSS CEEEEEEEEEECCHH	22.06	24719451
163	Ubiquitination	TVDFMSVKTVSSSSL EEEEEEEEECCHHHH	35.58	-
168	Phosphorylation	SVKTVSSSSLKAEKE EEEECCHHHHHHHHH	31.98	25690035
169	Phosphorylation	VKTVSSSSLKAEKET EEECCHHHHHHHHHH	35.52	25690035
171	Sumoylation	TVSSSSLKAEKETMR ECCHHHHHHHHHHHH	57.35	28112733
176	Phosphorylation	SLKAEKETMRKIEQE HHHHHHHHHHHHHHH	33.09	23401153
184	Ubiquitination	MRKIEQEKNQALEQS HHHHHHHHHHHHHHH	54.79	-
192	Ubiquitination	NQALEQSKLMERELN HHHHHHHHHHHHHCC	52.10	29967540
203	Ubiquitination	RELNPYWKDGGTGLP HHCCCCCCCCCCCCC	40.42	29967540
223	Phosphorylation	VSSITKVSVVEDGGL CCCCEEEEEEECCCC	23.23	26074081
231	Phosphorylation	VVEDGGLSWLRKSYL EEECCCCHHHHHHHH	27.60	26074081
261	Phosphorylation	IVAERYGSMEIFQSK HHHHHHCCHHHHHHH	12.33	28555341
268	Ubiquitination	SMEIFQSKLEDAEKA CHHHHHHHHHHHHHH	45.15	29967540
291	Phosphorylation	RERWRKPTYSDKAQN HHHHCCCCCCHHHHH	38.40	26657352
309	Ubiquitination	SRESDLVKYGNSSRD HHHHHHHHCCCCCCC	55.53	29967540
310	Phosphorylation	RESDLVKYGNSSRDR HHHHHHHCCCCCCCC	17.66	-
343	Phosphorylation	EKDKRPGSLETCRRE CCCCCCCCHHHHHHC	26.22	20873877
346	Phosphorylation	KRPGSLETCRRESNP CCCCCHHHHHHCCCC	19.33	23882029
351	Phosphorylation	LETCRRESNPRQNQE HHHHHHCCCCCCCCC	50.77	29214152
360	Phosphorylation	PRQNQEFSFGNLRAK CCCCCCCCCCCEEEE	31.34	23917254
367	Acetylation	SFGNLRAKFLRPSDD CCCCEEEEECCCCCC	38.20	25953088
372	Phosphorylation	RAKFLRPSDDEELSF EEEECCCCCCCCCCC	51.78	25159151
378	Phosphorylation	PSDDEELSFHSKGRK CCCCCCCCCCCCCCC	24.96	20873877
381	Phosphorylation	DEELSFHSKGRKFEP CCCCCCCCCCCCCCC	34.49	27080861
382	Ubiquitination	EELSFHSKGRKFEPL CCCCCCCCCCCCCCC	54.91	-
390	Phosphorylation	GRKFEPLSSSSALVA CCCCCCCCCCHHHHH	38.60	20562096
391	Phosphorylation	RKFEPLSSSSALVAQ CCCCCCCCCHHHHHC	35.67	20562096
392	Phosphorylation	KFEPLSSSSALVAQG CCCCCCCCHHHHHCC	19.09	20562096
393	Phosphorylation	FEPLSSSSALVAQGS CCCCCCCHHHHHCCC	27.80	-
400	Phosphorylation	SALVAQGSLCSGFRK HHHHHCCCCCCCCCC	17.70	20562096
403	Phosphorylation	VAQGSLCSGFRKPTK HHCCCCCCCCCCCCC	46.38	18491316
409	Phosphorylation	CSGFRKPTKNSEERL CCCCCCCCCCCHHHH	45.98	-
412	Phosphorylation	FRKPTKNSEERLTSW CCCCCCCCHHHHHHC	42.25	-
436	Phosphorylation	KHSNQKPSETSTDEH CCCCCCCCCCCCCCC	61.62	30576142
439	Phosphorylation	NQKPSETSTDEHQHV CCCCCCCCCCCCCCC	29.79	28555341
440	Phosphorylation	QKPSETSTDEHQHVP CCCCCCCCCCCCCCC	53.48	30576142
454	Phosphorylation	PEDPREKSQDEVLRD CCCCCCCCHHHHHHC	37.80	25159151
472	Phosphorylation	KKEHLRDTKSTFAGS CHHHHCCCCCCCCCC	22.06	26074081
474	Phosphorylation	EHLRDTKSTFAGSPE HHHCCCCCCCCCCCC	30.74	23927012
475	Phosphorylation	HLRDTKSTFAGSPER HHCCCCCCCCCCCCC	21.04	23927012
479	Phosphorylation	TKSTFAGSPERESIH CCCCCCCCCCCCCEE	21.84	29255136
484	Phosphorylation	AGSPERESIHILSVD CCCCCCCCEEEEECC	26.20	23927012
489	Phosphorylation	RESIHILSVDEKNKL CCCEEEEECCCCCCH	27.24	23927012
499	Ubiquitination	EKNKLGAKIIKAEMM CCCCHHHHHHHHHHH	43.07	29967540
521	Acetylation	QLKVQLEKANKFKET HHHHHHHHHHHHHHH	66.89	25953088
535	Ubiquitination	TITQIPKKSGVENED HHHHCCHHHCCCCCC	47.27	29967540
562	Phosphorylation	GRVWPVNTPGKSLES CCEEECCCCCCCHHH	33.38	21815630
565	Ubiquitination	WPVNTPGKSLESQGG EECCCCCCCHHHCCC	53.74	29967540
580	Phosphorylation	RRKRQMVSTHEERER HHCCCCCCCHHHHHH	20.78	23186163
581	Phosphorylation	RKRQMVSTHEERERV HCCCCCCCHHHHHHH	23.15	23186163
598	Phosphorylation	FHDDDNLSLNDLVKN CCCCCCCCHHHHHHH	31.23	20873877
604	Ubiquitination	LSLNDLVKNEKMGTA CCHHHHHHHCCCCCH	67.68	29967540
604	Sumoylation	LSLNDLVKNEKMGTA CCHHHHHHHCCCCCH	67.68	28112733
604	Sumoylation	LSLNDLVKNEKMGTA CCHHHHHHHCCCCCH	67.68	-
610	Phosphorylation	VKNEKMGTAENQNKL HHHCCCCCHHHHHHH	27.57	30622161
623	Phosphorylation	KLFMRMASKFMGKTD HHHHHHHHHHCCCCC	19.65	28985074
624	Acetylation	LFMRMASKFMGKTDG HHHHHHHHHCCCCCC	29.81	25953088
629	Phosphorylation	ASKFMGKTDGDYYTL HHHHCCCCCCCEECH	39.21	-
633	Phosphorylation	MGKTDGDYYTLDDMF CCCCCCCEECHHHHH	12.13	28796482
634	Phosphorylation	GKTDGDYYTLDDMFV CCCCCCEECHHHHHH	12.93	27642862
643	Ubiquitination	LDDMFVSKAAERERL HHHHHHHHHHHHHHH	46.44	29967540
742	Ubiquitination	MFRKSLVKMFEDKGL HHHHHHHHHHHHCCC	43.07	29967540
759	Phosphorylation	IFLETNMSMKKQYHM EEEECCCCHHHHCCE	29.53	24719451
764	Phosphorylation	NMSMKKQYHMVYECI CCCHHHHCCEEEEEE	10.77	27134283
768	Phosphorylation	KKQYHMVYECIPLPK HHHCCEEEEEEECCC	9.48	27134283
786	Ubiquitination	DMAPIYFKKAIMESD CCCCEEHHHHHHHCC	25.07	29967540
792	Phosphorylation	FKKAIMESDEEWSMN HHHHHHHCCHHHHCC	32.70	-
797	Phosphorylation	MESDEEWSMNKKLID HHCCHHHHCCHHHHC	18.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of C19L2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of C19L2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of C19L2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
FAM9B_HUMAN	FAM9B	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of C19L2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-479, AND MASSSPECTROMETRY.	17081983 [Abstract]