CCD57_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD57_HUMAN
• UniProt AC: Q2TAC2
• Protein Name: Coiled-coil domain-containing protein 57
• Gene Name: CCDC57
• Organism: Homo sapiens (Human).
• Sequence Length: 916
• Protein Sequence: MLPLGSEPALNELLLRKEEEWRALQAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREWEEARRAEVSELKIEAAKLRQALAREARKVEELQQQQQLAFQEHRLELERVHSDKNGEIDHHREQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRLQADNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAEWRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQVARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMAKSQVAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEEISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPDPEAGGDAATPDYVLALEAEIRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVRTSTETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQKVLREPLEPAALQRELPREVDQVHLEVLELRKQVAELGKHLRIAQHGGAEPSGRKQPPASDAVALGREQDAKSAEDEAPSRHLGKHQPRSAQVGSRLDALQGPKTQHSIHTVTCKSPRQKEDRSPKPPQAPQHPEEHGRQSHSSSSFASGTLQDMWRLLDLGSSPSGVTSQGDSTPELPAPPAADRRPVKMQAGIATPGMKTAAQAKAKTTGASRSHPAKAKGCQRPPKIRNYNIMD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MLPLGSEPALNEL --CCCCCCCHHHHHH	48.35	27251275
39	Phosphorylation	QEAALQDTRSQLEEA HHHHHHHHHHHHHHH	21.18	26546556
136	Phosphorylation	LELERVHSDKNGEID HHHHHHHCCCCCCCC	47.63	28355574
227	O-linked_Glycosylation	AGAKAAESLQRAEAT HHHHHHHHHHHHHHH	25.69	30379171
274	Methylation	LHSVQLTRKKEEETF HHHHHHCHHHHHHHH	57.55	-
315	Phosphorylation	EQLQELQTRVLELQA HHHHHHHHHHHHHHH	35.06	-
398	Phosphorylation	LKAQVARSQQDIERY HHHHHHHCHHHHHHH	23.58	26074081
405	Phosphorylation	SQQDIERYKQQLSLA CHHHHHHHHHHHHHH	10.60	26074081
445	Phosphorylation	ERDQIQKSEALIQGL CHHHHHHHHHHHHHH	16.24	17929957
453	Phosphorylation	EALIQGLSMAKSQVA HHHHHHHHHHHHHHH	24.42	17929957
457	Phosphorylation	QGLSMAKSQVAAKLQ HHHHHHHHHHHHHHH	21.98	-
622	Phosphorylation	ESQPSVRTSTETTGG CCCCCCCCCCCCCCC	37.53	-
626	O-linked_Glycosylation	SVRTSTETTGGSAQA CCCCCCCCCCCCCCC	30.72	30379171
630	Phosphorylation	STETTGGSAQAGQAG CCCCCCCCCCCCCCC	20.67	24275569
639	Phosphorylation	QAGQAGGSVQAGQAG CCCCCCCCCCCCCCC	15.33	24275569
639	O-linked_Glycosylation	QAGQAGGSVQAGQAG CCCCCCCCCCCCCCC	15.33	30379171
648	Phosphorylation	QAGQAGGSVQAGPVS CCCCCCCCCCCCCCC	15.33	24275569
655	Phosphorylation	SVQAGPVSSGLALRK CCCCCCCCHHHHHHH	23.09	-
656	Phosphorylation	VQAGPVSSGLALRKL CCCCCCCHHHHHHHH	37.75	24275569
739	Phosphorylation	GRKQPPASDAVALGR CCCCCCHHHHHHHCC	31.69	28348404
751	Acetylation	LGREQDAKSAEDEAP HCCHHHHHHHCCCCC	59.49	10514799
774	Phosphorylation	PRSAQVGSRLDALQG CCCCHHHCHHHHHCC	30.71	22210691
890	Phosphorylation	AQAKAKTTGASRSHP HHHHHHCCCCCCCCC	30.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD57_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD57_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD57_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUMA1_HUMAN	NUMA1	physical	23718855
CCD57_HUMAN	CCDC57	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
SFI1_HUMAN	SFI1	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.