SFI1_HUMAN - dbPTM
SFI1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SFI1_HUMAN
UniProt AC A8K8P3
Protein Name Protein SFI1 homolog
Gene Name SFI1
Organism Homo sapiens (Human).
Sequence Length 1242
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Localized close to the centriole.
Protein Description Plays a role in the dynamic structure of centrosome-associated contractile fibers via its interaction with CETN2..
Protein Sequence MKNLLTEKCISSHNFHQKVIKQRMEKKVDSRYFKDGAVKKPYSAKTLSNKKSSASFGIRRELPSTSHLVQYRGTHTCTRQGRLRELRIRCVARKFLYLWIRMTFGRVFPSKARFYYEQRLLRKVFEEWKEEWWVFQHEWKLCVRADCHYRYYLYNLMFQTWKTYVRQQQEMRNKYIRAEVHDAKQKMRQAWKSWLIYVVVRRTKLQMQTTALEFRQRIILRVWWSTWRQRLGQVRVSRALHASALKHRALSLQVQAWSQWREQLLYVQKEKQKVVSAVKHHQHWQKRRFLKAWLEYLQVRRVKRQQNEMAERFHHVTVLQIYFCDWQQAWERRESLYAHHAQVEKLARKMALRRAFTHWKHYMLLCAEEAAQFEMAEEHHRHSQLYFCFRALKDNVTHAHLQQIRRNLAHQQHGVTLLHRFWNLWRSQIEQKKERELLPLLHAAWDHYRIALLCKCIELWLQYTQKRRYKQLLQARADGHFQQRALPAAFHTWNRLWRWRHQENVLSARATRFHRETLEKQVFSLWRQKMFQHRENRLAERMAILHAERQLLYRSWFMWHQQAAARHQEQEWQTVACAHHRHGRLKKAFCLWRESAQGLRTERTGRVRAAEFHMAQLLRWAWSQWRECLALRGAERQKLMRADLHHQHSVLHRALQAWVTYQGRVRSILREVAARESQHNRQLLRGALRRWKENTMARVDEAKKTFQASTHYRRTICSKVLVQWREAVSVQMYYRQQEDCAIWEAQKVLDRGCLRTWFQRWWDCSRRSAQQRLQLERAVQHHHRQLLLEGLARWKTHHLQCVRKRLLHRQSTQLLAQRLSRTCFRQWRQQLAARRQEQRATVRALWFWAFSLQAKVWATWLAFVLERRRKKARLQWALQAYQGQLLQEGATRLLRFAASMKASRQQLQAQQQVQAAHSLHRAVRRCATLWKQKVLGRGGKPQPLAAIAPSRKVTFEGPLLNRIAAGAGDGTLETKRPQASRPLGALGRLAAEEPHALELNTAHSARKQPRRPHFLLEPAQSQRPQKPQEHGLGMAQPAAPSLTRPFLAEAPTALVPHSPLPGALSSAPGPKQPPTASTGPELLLLPLSSFMPCGAAAPARVSAQRATPRDKPPVPSSLASVPDPHLLLPGDFSATRAGPGLSTAGSLDLEAELEEIQQQLLHYQTTKQNLWSCRRQASSLRRWLELNREEPGPEDQEVEQQVQKELEQVEMQIQLLAEELQAQRQPIGACVARIQALRQALC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34UbiquitinationKVDSRYFKDGAVKKP
HCCCCCCCCCCCCCC		46.44-
42PhosphorylationDGAVKKPYSAKTLSN
CCCCCCCCCCCCCCC		30.0930631047
45UbiquitinationVKKPYSAKTLSNKKS
CCCCCCCCCCCCCCC		44.0229967540
55PhosphorylationSNKKSSASFGIRREL
CCCCCCCCCCCCCCC		26.4225332170
71PhosphorylationSTSHLVQYRGTHTCT
CCCCCEEECCCCCCC		11.9723879269
74PhosphorylationHLVQYRGTHTCTRQG
CCEEECCCCCCCCCC		12.6623879269
76PhosphorylationVQYRGTHTCTRQGRL
EEECCCCCCCCCCCH		18.5323879269
152PhosphorylationADCHYRYYLYNLMFQ
CCCHHHHHHHHHHHH		8.16-
154PhosphorylationCHYRYYLYNLMFQTW
CHHHHHHHHHHHHHH		7.07-
163PhosphorylationLMFQTWKTYVRQQQE
HHHHHHHHHHHHHHH		20.8629978859
164PhosphorylationMFQTWKTYVRQQQEM
HHHHHHHHHHHHHHH		7.0129978859
193PhosphorylationKMRQAWKSWLIYVVV
HHHHHHHHHHHHHHH		19.2022617229
197UbiquitinationAWKSWLIYVVVRRTK
HHHHHHHHHHHHCCC		5.7529967540
197PhosphorylationAWKSWLIYVVVRRTK
HHHHHHHHHHHHCCC		5.7522617229
255UbiquitinationRALSLQVQAWSQWRE
HHHHHHHHHHHHHHH		24.9329967540
279UbiquitinationQKVVSAVKHHQHWQK
HHHHHHHHCHHHHHH		34.7829967540
301UbiquitinationLEYLQVRRVKRQQNE
HHHHHHHHHHHHHHH		39.1827667366
318UbiquitinationERFHHVTVLQIYFCD
HHHCCCEEEEEEEEC		3.4427667366
390UbiquitinationSQLYFCFRALKDNVT
HHHHHHHHHHHCCCC		39.9427667366
511O-linked_GlycosylationNVLSARATRFHRETL
CHHHHHHHHHHHHHH		28.45OGP
524PhosphorylationTLEKQVFSLWRQKMF
HHHHHHHHHHHHHHH		28.3224719451
604PhosphorylationQGLRTERTGRVRAAE
CCCCCCCCCCCCHHH		24.0922210691
653 (in isoform 5)Phosphorylation-32.6027174698
667 (in isoform 5)Phosphorylation-24.1027174698
695PhosphorylationLRRWKENTMARVDEA
HHHHHHHHHHHHHHH		17.19-
733PhosphorylationEAVSVQMYYRQQEDC
HHHHHHCHHHCHHCH		4.38-
734PhosphorylationAVSVQMYYRQQEDCA
HHHHHCHHHCHHCHH		9.15-
771UbiquitinationCSRRSAQQRLQLERA
CCHHHHHHHHHHHHH		48.0127667366
795UbiquitinationLEGLARWKTHHLQCV
HHHHHHHHHHHHHHH		32.21-
827UbiquitinationSRTCFRQWRQQLAAR
HHHHHHHHHHHHHHH		8.8727667366
844UbiquitinationEQRATVRALWFWAFS
HHHHHHHHHHHHHHH		12.5727667366
846UbiquitinationRATVRALWFWAFSLQ
HHHHHHHHHHHHHHH		5.9227667366
858UbiquitinationSLQAKVWATWLAFVL
HHHHHHHHHHHHHHH		7.5927667366
870UbiquitinationFVLERRRKKARLQWA
HHHHHHHHHHHHHHH		49.3127667366
875UbiquitinationRRKKARLQWALQAYQ
HHHHHHHHHHHHHHH		20.1727667366
881UbiquitinationLQWALQAYQGQLLQE
HHHHHHHHHHHHHHH		10.5429967540
885UbiquitinationLQAYQGQLLQEGATR
HHHHHHHHHHHHHHH		7.3427667366
893UbiquitinationLQEGATRLLRFAASM
HHHHHHHHHHHHHHH		3.3229967540
897UbiquitinationATRLLRFAASMKASR
HHHHHHHHHHHHHHH		7.6829967540
901UbiquitinationLRFAASMKASRQQLQ
HHHHHHHHHHHHHHH		40.49-
902UbiquitinationRFAASMKASRQQLQA
HHHHHHHHHHHHHHH		10.9927667366
909UbiquitinationASRQQLQAQQQVQAA
HHHHHHHHHHHHHHH		20.1027667366
916UbiquitinationAQQQVQAAHSLHRAV
HHHHHHHHHHHHHHH		3.9227667366
918PhosphorylationQQVQAAHSLHRAVRR
HHHHHHHHHHHHHHH		22.5727174698
920UbiquitinationVQAAHSLHRAVRRCA
HHHHHHHHHHHHHHH		20.7629967540
921UbiquitinationQAAHSLHRAVRRCAT
HHHHHHHHHHHHHHH		39.8229967540
926UbiquitinationLHRAVRRCATLWKQK
HHHHHHHHHHHHHHH		2.0827667366
933UbiquitinationCATLWKQKVLGRGGK
HHHHHHHHHCCCCCC		35.3827667366
940UbiquitinationKVLGRGGKPQPLAAI
HHCCCCCCCCCCCEE		43.2227667366
944UbiquitinationRGGKPQPLAAIAPSR
CCCCCCCCCEECCCC		4.1829967540
952UbiquitinationAAIAPSRKVTFEGPL
CEECCCCCEEECCCH		50.3829967540
957UbiquitinationSRKVTFEGPLLNRIA
CCCEEECCCHHHHHH		17.6027667366
971PhosphorylationAAGAGDGTLETKRPQ
HCCCCCCCCCCCCCC		26.5924173317
975UbiquitinationGDGTLETKRPQASRP
CCCCCCCCCCCCCCC		53.3529967540
1001PhosphorylationPHALELNTAHSARKQ
CCHHHCCCCCHHCCC		38.0728555341
1004PhosphorylationLELNTAHSARKQPRR
HHCCCCCHHCCCCCC		27.5728555341
1111UbiquitinationQRATPRDKPPVPSSL
CCCCCCCCCCCCHHH		53.12-
1146PhosphorylationPGLSTAGSLDLEAEL
CCCCCCCCCCHHHHH		19.0824719451
1179PhosphorylationSCRRQASSLRRWLEL
HHHHHHHHHHHHHHH		28.9817081983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SFI1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SFI1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SFI1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RADIL_HUMANRADILphysical
16189514
SFI1_HUMANSFI1physical
25416956
MD2L2_HUMANMAD2L2physical
25416956
SRTD1_HUMANSERTAD1physical
25416956
CC120_HUMANCCDC120physical
25416956
CCD57_HUMANCCDC57physical
25416956
F131C_HUMANFAM131Cphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SFI1_HUMAN

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Related Literatures of Post-Translational Modification

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