RADIL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RADIL_HUMAN
• UniProt AC: Q96JH8
• Protein Name: Ras-associating and dilute domain-containing protein
• Gene Name: RADIL
• Organism: Homo sapiens (Human).
• Sequence Length: 1075
• Protein Description: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development..
• Protein Sequence: MFYGTHFIMSPPTKSKLKRQSQLLSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLSAPGVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDAGQRWQARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGINAQARRLQRSRAKGTPTPALGDARSSPPPRLRRTVSETSLSPVNALPAAAQGPEEPGPDAMRYSLYQSPHLLLLQGYSQQHDSLVYVLNRDRHTVGQRTPSSKPSISLSAPDILPLHCTIRRQPLPDSGQAAGRLVLEPIPGAHISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQSCRLCGAALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSATHFQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMADLVPDLQPILFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQMLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNLLATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLESYENPPPIVLPSDGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGSPGRPGSGASQPVCPEGMHHVVLDGHLEAPSCPLAPRDPGPAAREVAPERTLPLRGAPWAQAPPGRQPSRGGSQAGPPHTDSSCLLTPPSTPLGPEPGDPDWPESGGPCGKALPERQRNGLSGLRGAAPEGDSAALAEESPPAPSSRSSSTEDFCYVFTVELERGPSGLGMGLIDGMHTHLGAPGLYIQTLLPGSPAAADGRLSLGDRILEVNGSSLLGLGYLRAVDLIRHGGKKMRFLVAKSDVETAKKIHFRTPPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFYGTHFIMS -----CCCCCCCCCC	32.73	25072903
5	Phosphorylation	---MFYGTHFIMSPP ---CCCCCCCCCCCC	11.39	25072903
10	Phosphorylation	YGTHFIMSPPTKSKL CCCCCCCCCCCHHHH	23.94	27732954
13	Phosphorylation	HFIMSPPTKSKLKRQ CCCCCCCCHHHHHHH	51.86	25072903
15	Phosphorylation	IMSPPTKSKLKRQSQ CCCCCCHHHHHHHHH	45.78	29083192
33	Phosphorylation	SMLSRTLSYKYRDLD HHHHHHHHHHHCCHH	20.97	-
78	Phosphorylation	SVCTGTHYKSVLATG CCCCCCCHHHHHCCC	12.56	-
175	Phosphorylation	LAAKEVDTITAGINA HHHHHCCHHHHHHHH	25.96	22617229
197	Phosphorylation	SRAKGTPTPALGDAR HHCCCCCCCCCCCCC	22.49	22210691
205	Phosphorylation	PALGDARSSPPPRLR CCCCCCCCCCCCCCC	49.25	23186163
206	Phosphorylation	ALGDARSSPPPRLRR CCCCCCCCCCCCCCC	35.55	17081983
214	Phosphorylation	PPPRLRRTVSETSLS CCCCCCCCCCCCCCC	23.19	29978859
216	Phosphorylation	PRLRRTVSETSLSPV CCCCCCCCCCCCCHH	34.25	33259812
218	Phosphorylation	LRRTVSETSLSPVNA CCCCCCCCCCCHHHC	27.71	29978859
219	Phosphorylation	RRTVSETSLSPVNAL CCCCCCCCCCHHHCC	23.85	29978859
221	Phosphorylation	TVSETSLSPVNALPA CCCCCCCCHHHCCCH	26.94	29978859
336	Phosphorylation	FSEVGHRTVVLHHGD HHHCCCEEEEEEHHH	14.86	26503514
346	Phosphorylation	LHHGDLLSLGLYYLL EEHHHHHHHHHHHHH	27.91	26503514
350	Phosphorylation	DLLSLGLYYLLLFKD HHHHHHHHHHHHCCC	7.11	26503514
351	Phosphorylation	LLSLGLYYLLLFKDP HHHHHHHHHHHCCCH	8.91	26503514
393	Phosphorylation	LGARGAASPTQAALP HCCCCCCCHHHCCCC	28.13	22617229
395	Phosphorylation	ARGAASPTQAALPRR CCCCCCHHHCCCCHH	28.48	27732954
538	Phosphorylation	MEEQLDITGSKESLF HHHHHCCCCCCHHHH	34.76	26471730
540	Phosphorylation	EQLDITGSKESLFSC HHHCCCCCCHHHHEE	25.30	27251275
598	Phosphorylation	FQTERRESWSSAPEL CCCCCCCCCCCCCCC	30.37	27422710
600	Phosphorylation	TERRESWSSAPELPE CCCCCCCCCCCCCCH	26.38	27251275
601	Phosphorylation	ERRESWSSAPELPEE CCCCCCCCCCCCCHH	41.40	27251275
815	Phosphorylation	WGLRSRASPGSPGRP HHCCCCCCCCCCCCC	28.78	27251275
818	Phosphorylation	RSRASPGSPGRPGSG CCCCCCCCCCCCCCC	27.80	28348404
890	Phosphorylation	RQPSRGGSQAGPPHT CCCCCCCCCCCCCCC	21.49	29449344
897	Phosphorylation	SQAGPPHTDSSCLLT CCCCCCCCCCCCEEC	43.27	29449344
899	Phosphorylation	AGPPHTDSSCLLTPP CCCCCCCCCCEECCC	24.89	29449344
900	Phosphorylation	GPPHTDSSCLLTPPS CCCCCCCCCEECCCC	16.17	29449344
904	Phosphorylation	TDSSCLLTPPSTPLG CCCCCEECCCCCCCC	21.87	29449344
907	Phosphorylation	SCLLTPPSTPLGPEP CCEECCCCCCCCCCC	43.81	29449344
908	Phosphorylation	CLLTPPSTPLGPEPG CEECCCCCCCCCCCC	28.45	29449344
939	Phosphorylation	ERQRNGLSGLRGAAP HHHHCCCCCCCCCCC	36.86	24719451
957	Phosphorylation	SAALAEESPPAPSSR HHHHHCCCCCCCCCC	27.91	27732954
962	Phosphorylation	EESPPAPSSRSSSTE CCCCCCCCCCCCCCC	40.25	29978859
963	Phosphorylation	ESPPAPSSRSSSTED CCCCCCCCCCCCCCC	34.81	29978859
1072	Phosphorylation	AKKIHFRTPPL---- HHHHCCCCCCC----	28.45	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RADIL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RADIL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RADIL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHXF2_HUMAN	RHOXF2	physical	16189514
RAP1A_HUMAN	RAP1A	physical	20048162
GBB1_HUMAN	GNB1	physical	20048162
CEP76_HUMAN	CEP76	physical	25416956
MR1L1_HUMAN	MRFAP1L1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.