| UniProt ID | SRTD1_HUMAN | |
|---|---|---|
| UniProt AC | Q9UHV2 | |
| Protein Name | SERTA domain-containing protein 1 | |
| Gene Name | SERTAD1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 236 | |
| Subcellular Localization | ||
| Protein Description | Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.. | |
| Protein Sequence | MLSKGLKRKREEEEEKEPLAVDSWWLDPGHTAVAQAPPAVASSSLFDLSVLKLHHSLQQSEPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADNLLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGPATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYLMDVLVGTQALERPPGPGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of SRTD1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRTD1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRTD1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRTD1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KLH42_HUMAN | KLHL42 | physical | 16189514 | |
| CDK4_HUMAN | CDK4 | physical | 15065884 | |
| CCND2_HUMAN | CCND2 | physical | 15065884 | |
| CDN2A_HUMAN | CDKN2A | physical | 15065884 | |
| ARF_HUMAN | CDKN2A | physical | 15065884 | |
| CDK4_HUMAN | CDK4 | physical | 10580009 | |
| ST65G_HUMAN | SUPT7L | physical | 17141982 | |
| KAT2B_HUMAN | KAT2B | physical | 17141982 | |
| TIF1B_HUMAN | TRIM28 | physical | 17141982 | |
| CHUR_HUMAN | CHURC1 | physical | 20211142 | |
| SETD7_HUMAN | SETD7 | physical | 21988832 | |
| TGM2_HUMAN | TGM2 | physical | 21988832 | |
| MINT_HUMAN | SPEN | physical | 21988832 | |
| SMAD3_HUMAN | SMAD3 | physical | 21988832 | |
| STA5B_HUMAN | STAT5B | physical | 21988832 | |
| TLR4_HUMAN | TLR4 | physical | 21988832 | |
| ROP1A_HUMAN | ROPN1 | physical | 25416956 | |
| ZN410_HUMAN | ZNF410 | physical | 25416956 | |
| EGLN3_HUMAN | EGLN3 | physical | 25416956 | |
| CIB3_HUMAN | CIB3 | physical | 25416956 | |
| PATE1_HUMAN | PATE1 | physical | 25416956 | |
| P4HA3_HUMAN | P4HA3 | physical | 25416956 | |
| ADCY1_HUMAN | ADCY1 | physical | 28656888 | |
| XIAP_HUMAN | XIAP | physical | 28656888 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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