ADCY1_HUMAN - dbPTM
ADCY1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADCY1_HUMAN
UniProt AC Q08828
Protein Name Adenylate cyclase type 1
Gene Name ADCY1
Organism Homo sapiens (Human).
Sequence Length 1119
Subcellular Localization Membrane
Multi-pass membrane protein . Cell membrane
Multi-pass membrane protein . Cytoplasm . Membrane raft . Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and
Protein Description Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity)..
Protein Sequence MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52PhosphorylationLEALFRGYTLRLEQA
HHHHHCCCCCCHHHH		9.8021697673
53PhosphorylationEALFRGYTLRLEQAA
HHHHCCCCCCHHHHH		14.29113136083
61PhosphorylationLRLEQAATLKALAVL
CCHHHHHHHHHHHHH		31.63113136091
69PhosphorylationLKALAVLSLLAGALA
HHHHHHHHHHHHHHH		18.10113136099
248PhosphorylationKAFLQARSCIEDRLR
HHHHHHHHHHHHHHC		23.5924719451
293UbiquitinationPPERIFHKIYIQRHD
CHHHHHHHHHHCCCC		26.84-
354PhosphorylationIKILGDCYYCVSGLT
EEECCCCCHHHCCCC		12.4930177828
355PhosphorylationKILGDCYYCVSGLTQ
EECCCCCHHHCCCCC		7.8430177828
358PhosphorylationGDCYYCVSGLTQPKT
CCCCHHHCCCCCCCC		25.2330177828
361PhosphorylationYYCVSGLTQPKTDHA
CHHHCCCCCCCCCCH		46.4830177828
416PhosphorylationLGLRKWQYDVWSNDV
HCCCCCEEEECCCCE		16.0211304733
464PhosphorylationGYGHERNSFLKTHNI
CCCCCCCCCCCCCCC		37.8724719451
550PhosphorylationSEKLRNRSSFSTNVV
HHHHHCCCCCCCCEE		39.0123663014
551PhosphorylationEKLRNRSSFSTNVVY
HHHHCCCCCCCCEEE		21.7123663014
553PhosphorylationLRNRSSFSTNVVYTT
HHCCCCCCCCEEECC		22.4823663014
554PhosphorylationRNRSSFSTNVVYTTP
HCCCCCCCCEEECCC		29.9823663014
558PhosphorylationSFSTNVVYTTPGTRV
CCCCCEEECCCCHHH		10.7023663014
559PhosphorylationFSTNVVYTTPGTRVN
CCCCEEECCCCHHHH		18.2023663014
560PhosphorylationSTNVVYTTPGTRVNR
CCCEEECCCCHHHHH		11.3123663014
563PhosphorylationVVYTTPGTRVNRYIS
EEECCCCHHHHHHHH		32.4223663014
704N-linked_GlycosylationWAWSSKPNSSLVVLS
CCCCCCCCCEEEEEE		48.22UniProtKB CARBOHYD
761PhosphorylationILLSGLTTSYILVLE
HHHHCCCCEEEEEEE		25.2822210691
763PhosphorylationLSGLTTSYILVLELS
HHCCCCEEEEEEECC		9.0022210691
770PhosphorylationYILVLELSGYTRTGG
EEEEEECCCCCCCCC		22.0022210691
924PhosphorylationEKIKTIGSTYMAAVG
HHHHCCCCHHHHHHE		16.7121214269
926PhosphorylationIKTIGSTYMAAVGLA
HHCCCCHHHHHHEEC		6.1021214269
935PhosphorylationAAVGLAPTSGTKAKK
HHHEECCCCCCHHHH		33.8930849919
936PhosphorylationAVGLAPTSGTKAKKS
HHEECCCCCCHHHHH		43.3221214269
996PhosphorylationIGARRPQYDIWGNTV
HCCCCCCCCCCCCEE		16.4522210691
1007PhosphorylationGNTVNVASRMDSTGV
CCEEEHHHHCCCCCC		24.69-
1011PhosphorylationNVASRMDSTGVQGRI
EHHHHCCCCCCCCCE		20.0922210691
1012PhosphorylationVASRMDSTGVQGRIQ
HHHHCCCCCCCCCEE		36.7922210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADCY1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADCY1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADCY1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SRTD1_HUMANSERTAD1physical
28656888
Drug and Disease Associations
Kegg Disease
OMIM Disease
610154Deafness, autosomal recessive, 44 (DFNB44)
Kegg Drug
DrugBank
DB00131Adenosine monophosphate
DB00171Adenosine triphosphate
Regulatory Network of ADCY1_HUMAN

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Related Literatures of Post-Translational Modification

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