SPN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPN1_HUMAN
• UniProt AC: O95149
• Protein Name: Snurportin-1
• Gene Name: SNUPN
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Nucleus . Cytoplasm . Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1-dependent nuclear export rece
• Protein Description: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs..
• Protein Sequence: MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEELSQAL -------CHHHHHHH	9.01	20068231
10	Phosphorylation	ELSQALASSFSVSQD HHHHHHHHCCCCCCC	32.53	28348404
11	Phosphorylation	LSQALASSFSVSQDL HHHHHHHCCCCCCCC	18.88	28348404
13	Phosphorylation	QALASSFSVSQDLNS HHHHHCCCCCCCCCC	23.86	28348404
15	Phosphorylation	LASSFSVSQDLNSTA HHHCCCCCCCCCCCC	19.44	28348404
20	Phosphorylation	SVSQDLNSTAAPHPR CCCCCCCCCCCCCCC	27.07	28122231
21	Phosphorylation	VSQDLNSTAAPHPRL CCCCCCCCCCCCCCH	26.26	28122231
29	Phosphorylation	AAPHPRLSQYKSKYS CCCCCCHHHHHHHHH	32.51	20068231
31	Phosphorylation	PHPRLSQYKSKYSSL CCCCHHHHHHHHHHH	17.54	20068231
32	Ubiquitination	HPRLSQYKSKYSSLE CCCHHHHHHHHHHHH	32.60	29967540
34	Ubiquitination	RLSQYKSKYSSLEQS CHHHHHHHHHHHHHH	45.03	-
34	Sumoylation	RLSQYKSKYSSLEQS CHHHHHHHHHHHHHH	45.03	-
34	Sumoylation	RLSQYKSKYSSLEQS CHHHHHHHHHHHHHH	45.03	-
35	Phosphorylation	LSQYKSKYSSLEQSE HHHHHHHHHHHHHHH	15.58	28796482
36	Phosphorylation	SQYKSKYSSLEQSER HHHHHHHHHHHHHHH	31.98	-
37	Phosphorylation	QYKSKYSSLEQSERR HHHHHHHHHHHHHHH	32.60	28857561
41	Phosphorylation	KYSSLEQSERRRRLL HHHHHHHHHHHHHHH	24.56	21815630
52	Ubiquitination	RRLLELQKSKRLDYV HHHHHHHHHHHHHHH	71.25	29967540
71	Phosphorylation	RLAEDDWTGMESEEE HHHHCCCCCCCCHHH	33.38	30576142
75	Phosphorylation	DDWTGMESEEENKKD CCCCCCCCHHHHCCC	41.22	25159151
90	Phosphorylation	DEEMDIDTVKKLPKH CHHCCHHHHHHHCHH	34.26	29978859
92	Ubiquitination	EMDIDTVKKLPKHYA HCCHHHHHHHCHHHH	51.16	29967540
135	Phosphorylation	KRALIVASRGSTSAY CCEEEEEECCCCCCC	26.70	30576142
138	Phosphorylation	LIVASRGSTSAYTKS EEEEECCCCCCCCCC	20.34	22210691
142	Phosphorylation	SRGSTSAYTKSGYCV ECCCCCCCCCCCCCC	17.92	30576142
144	Ubiquitination	GSTSAYTKSGYCVNR CCCCCCCCCCCCCHH	29.25	21963094
147	Phosphorylation	SAYTKSGYCVNRFSS CCCCCCCCCCHHHHH	10.58	30576142
153	Phosphorylation	GYCVNRFSSLLPGGN CCCCHHHHHCCCCCC	19.48	23879269
154	Phosphorylation	YCVNRFSSLLPGGNR CCCHHHHHCCCCCCC	31.08	20873877
164	Phosphorylation	PGGNRRNSTAKDYTI CCCCCCCCCCCCCCH	28.12	23882029
165	Phosphorylation	GGNRRNSTAKDYTIL CCCCCCCCCCCCCHH	41.07	23882029
182	O-linked_Glycosylation	IYNEVNQTYYVLDVM HCCCCCCEEEEEEEE	16.18	29351928
199	S-nitrosylation	RGHPFYDCQTDFRFY CCCCCCCCCCCCEEE	2.98	24105792
221	Ubiquitination	EEEGLGEKTKLNPFK CCCCCCCCCCCCCCC	49.51	21906983
223	Ubiquitination	EGLGEKTKLNPFKFV CCCCCCCCCCCCCCC	58.28	29967540
228	Ubiquitination	KTKLNPFKFVGLKNF CCCCCCCCCCCCCCC	40.16	21890473
228	Ubiquitination	KTKLNPFKFVGLKNF CCCCCCCCCCCCCCC	40.16	21906983
298	Sumoylation	PAGPLTTKPDYAGHQ CCCCCCCCCCCHHHH	30.56	-
301	Phosphorylation	PLTTKPDYAGHQLQQ CCCCCCCCHHHHHHH	24.02	-
325	Phosphorylation	EGMKEKLTHKASENG HHHHHHHCCHHHHCC	32.19	28348404
329	Phosphorylation	EKLTHKASENGHYEL HHHCCHHHHCCCEEE	36.08	21945579
334	Phosphorylation	KASENGHYELEHLST HHHHCCCEEEEECCC	24.49	21945579
340	Phosphorylation	HYELEHLSTPKLKGS CEEEEECCCCCCCCC	44.57	21945579
341	Phosphorylation	YELEHLSTPKLKGSS EEEEECCCCCCCCCC	30.70	21945579
347	Phosphorylation	STPKLKGSSHSPDHP CCCCCCCCCCCCCCC	24.24	23401153
348	Phosphorylation	TPKLKGSSHSPDHPG CCCCCCCCCCCCCCC	36.33	22115753
350	Phosphorylation	KLKGSSHSPDHPGCL CCCCCCCCCCCCCCC	33.69	23401153
356	S-nitrosylation	HSPDHPGCLMEN--- CCCCCCCCCCCC---	3.73	24105792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	MEX3B	Q6ZN04	PMID:24326307

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNT3_HUMAN	TNNT3	physical	16169070
ENOG_HUMAN	ENO2	physical	16169070
PEX5_HUMAN	PEX5	physical	16169070
SMN_HUMAN	SMN1	physical	12095920
DDX20_HUMAN	DDX20	physical	12095920
RSMB_HUMAN	SNRPB	physical	12095920
ZPR1_HUMAN	ZPR1	physical	12095920
RAN_HUMAN	RAN	physical	10209022
XPO1_HUMAN	XPO1	physical	10209022
IMB1_HUMAN	KPNB1	physical	10209022
DREB_HUMAN	DBN1	physical	21900206
MEX3B_HUMAN	MEX3B	physical	21900206
RN126_HUMAN	RNF126	physical	21900206
PDP1_HUMAN	PDP1	physical	26186194
TOE1_HUMAN	TOE1	physical	26186194
EGLN1_HUMAN	EGLN1	physical	26186194
UBP15_HUMAN	USP15	physical	26186194
SMD1_HUMAN	SNRPD1	physical	26186194
PDP1_HUMAN	PDP1	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.