TNNT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNT3_HUMAN
• UniProt AC: P45378
• Protein Name: Troponin T, fast skeletal muscle
• Gene Name: TNNT3
• Organism: Homo sapiens (Human).
• Sequence Length: 269
• Protein Description: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity..
• Protein Sequence: MSDEEVEQVEEQYEEEEEAQEEAAEVHEEVHEPEEVQEDTAEEDAEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDEEVEQV ------CCHHHHHHH	54.45	-
2	Acetylation	------MSDEEVEQV ------CCHHHHHHH	54.45	-
2 (in isoform 4)	Phosphorylation	-	54.45	22673903
2 (in isoform 3)	Phosphorylation	-	54.45	22673903
2 (in isoform 7)	Phosphorylation	-	54.45	22673903
2 (in isoform 6)	Phosphorylation	-	54.45	22673903
2 (in isoform 5)	Phosphorylation	-	54.45	22673903
13	Phosphorylation	VEQVEEQYEEEEEAQ HHHHHHHHHHHHHHH	28.70	-
13 (in isoform 6)	Phosphorylation	-	28.70	22673903
88	Phosphorylation	ELQALIDSHFEARKK HHHHHHHHHHHHHHH	24.07	-
119	Methylation	AERAEQQRIRAEKER HHHHHHHHHHHHHHH	21.76	24384347
136	2-Hydroxyisobutyrylation	QNRLAEEKARREEED HHHHHHHHHHHHHHH	38.40	-
159	Phosphorylation	LKKKKALSSMGANYS HHHHHHHHHCCCCHH	24.12	19764811
160	Phosphorylation	KKKKALSSMGANYSS HHHHHHHHCCCCHHH	23.29	24719451
165	Phosphorylation	LSSMGANYSSYLAKA HHHCCCCHHHHHHHH	9.84	-
166	Phosphorylation	SSMGANYSSYLAKAD HHCCCCHHHHHHHHH	16.59	19764811
167	Phosphorylation	SMGANYSSYLAKADQ HCCCCHHHHHHHHHH	17.51	19764811
168	Phosphorylation	MGANYSSYLAKADQK CCCCHHHHHHHHHHH	12.53	-
234 (in isoform 4)	Phosphorylation	-	48.97	28152594
254	Acetylation	DQAQKHSKKAGTPAK HHHHHHHHHCCCCCC	46.49	7959379
261	Acetylation	KKAGTPAKGKVGGRW HHCCCCCCCCCCCCC	61.54	7959393
263	Acetylation	AGTPAKGKVGGRWK- CCCCCCCCCCCCCC-	36.68	7959407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	16169070
TNNT3_HUMAN	TNNT3	physical	8987992
TNNC1_RABIT	TNNC1	physical	8987992
TNNI2_RABIT	TNNI2	physical	8987992
TPM1_RABIT	TPM1	physical	8987992
TNNC2_RABIT	TNNC2	physical	9724539
TNNI2_RABIT	TNNI2	physical	9724539
TPM1_RABIT	TPM1	physical	9724539
TNNI2_RABIT	TNNI2	physical	15507453

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.