TNNC2_RABIT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNC2_RABIT
• UniProt AC: P02586
• Protein Name: Troponin C, skeletal muscle
• Gene Name: TNNC2
• Organism: Oryctolagus cuniculus (Rabbit).
• Sequence Length: 160
• Protein Description: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments..
• Protein Sequence: MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDAEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTDQQAEAR ------CCHHHHHHH	42.38	893419
21	Acetylation	EEMIAEFKAAFDMFD HHHHHHHHHHHHHCC	30.25	7662676
38	Acetylation	GGGDISVKELGTVMR CCCCEEHHHHHHHHH	40.19	7662676
53	Acetylation	MLGQTPTKEELDAII HHCCCCCHHHHHHHH	50.85	7662676
85	Acetylation	VMMVRQMKEDAKGKS HHHHHHHHHHHCCCC	44.07	7662676
89	Acetylation	RQMKEDAKGKSEEEL HHHHHHHCCCCHHHH	78.26	7662676
89	Ubiquitination	RQMKEDAKGKSEEEL HHHHHHHCCCCHHHH	78.26	-
91	Acetylation	MKEDAKGKSEEELAE HHHHHCCCCHHHHHH	54.72	7662676
91	Ubiquitination	MKEDAKGKSEEELAE HHHHHCCCCHHHHHH	54.72	-
137	Acetylation	EEIESLMKDGDKNND HHHHHHHHHCCCCCC	64.95	7662676
141	Acetylation	SLMKDGDKNNDGRID HHHHHCCCCCCCCCC	64.28	7662676
154	Acetylation	IDFDEFLKMMEGVQ- CCHHHHHHHHHCCC-	41.33	7662676

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNNC2_RABIT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNC2_RABIT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNC2_RABIT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNNI2_RABIT	TNNI2	physical	9724539

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Isolation and sequence of a cDNA clone for rabbit fast skeletalmuscle troponin C. Homology with calmodulin and parvalbumin.";
Zot A.S., Potter J.D., Strauss W.L.;
J. Biol. Chem. 262:15418-15421(1987).
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
PubMed: 3680204