TNNI2_RABIT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNNI2_RABIT
• UniProt AC: P02643
• Protein Name: Troponin I, fast skeletal muscle
• Gene Name: TNNI2
• Organism: Oryctolagus cuniculus (Rabbit).
• Sequence Length: 182
• Protein Description: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity..
• Protein Sequence: MGDEEKRNRAITARRQHLKSVMLQIAATELEKEEGRREAEKQNYLAEHCPPLSLPGSMAEVQELCKQLHAKIDAAEEEKYDMEIKVQKSSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDEEKRNR ------CCHHHHHHH	51.54	1180911
12	Phosphorylation	EKRNRAITARRQHLK HHHHHHHHHHHHHHH	17.08	4369265
20	Phosphorylation	ARRQHLKSVMLQIAA HHHHHHHHHHHHHHH	21.08	4369265
118	Phosphorylation	PLRRVRMSADAMLKA CHHHHHHCHHHHHHH	16.66	4369265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	T	Phosphorylation	Kinase	PHK-FAMILY	-	GPS
12	T	Phosphorylation	Kinase	PHK	-	Uniprot
12	T	Phosphorylation	Kinase	PHK_GROUP	-	PhosphoELM
20	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
20	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
118	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
118	S	Phosphorylation	Kinase	PKA	-	Uniprot
118	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNNI2_RABIT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNNI2_RABIT !!

Protein-Protein Interaction

Oops, there are no PPI records of TNNI2_RABIT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The amino acid sequences of the phosphorylated sites in troponin-Ifrom rabbit skeletal muscle.";
Huang T.S., Bylund D.B., Stull J.T., Krebs E.G.;
FEBS Lett. 42:249-252(1974).
Cited for: PHOSPHORYLATION AT THR-12 AND SER-118.
PubMed: 4369265

"The phosphorylation sites of troponin I from white skeletal muscle ofthe rabbit.";
Moir A.J.G., Wilkinson J.M., Perry S.V.;
FEBS Lett. 42:253-256(1974).
Cited for: PHOSPHORYLATION AT THR-12 AND SER-118.
PubMed: 4369337