MEX3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEX3B_HUMAN
• UniProt AC: Q6ZN04
• Protein Name: RNA-binding protein MEX3B
• Gene Name: MEX3B
• Organism: Homo sapiens (Human).
• Sequence Length: 569
• Subcellular Localization: Nucleus . Cytoplasm . Cytoplasm, P-body . Cytoplasmic granule . Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
• Protein Description: RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms..
• Protein Sequence: MPSSLFADLERNGSGGGGGGSSGGGETLDDQRALQLALDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPGPPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPTPSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSSSAAATQRLADYSPPSPALSFAHNGNNNNNGNGYTYTAGGEASVPSPDGCPELQPTFDPAPAPPPGAPLIWAQFERSPGGGPAAPVSSSCSSSASSSASSSSVVFPGGGASAPSNANLGLLVHRRLHPGTSCPRLSPPLHMAPGAGEHHLARRVRSDPGGGGLAYAAYANGLGAQLPGLQPSDTSGSSSSSSSSSSSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHTAVTQAIRIFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSSLFADLE -----CCCCCCCCCC	38.07	25850435
4	Phosphorylation	----MPSSLFADLER ----CCCCCCCCCCC	22.95	23401153
21	Phosphorylation	SGGGGGGSSGGGETL CCCCCCCCCCCCCCC	29.14	23532336
22	Phosphorylation	GGGGGGSSGGGETLD CCCCCCCCCCCCCCC	44.74	23532336
42	Phosphorylation	QLALDQLSLLGLDSD HHHHHHHHHCCCCCC	18.86	27732954
48	Phosphorylation	LSLLGLDSDEGASLY HHHCCCCCCCCCCCC	42.47	27732954
53	Phosphorylation	LDSDEGASLYDSEPR CCCCCCCCCCCCCCC	38.02	27732954
55	Phosphorylation	SDEGASLYDSEPRKK CCCCCCCCCCCCCCC	18.22	27732954
57	Phosphorylation	EGASLYDSEPRKKSV CCCCCCCCCCCCCCC	35.62	27732954
63	Phosphorylation	DSEPRKKSVNMTECV CCCCCCCCCCCEEEE	23.04	29507054
67	Phosphorylation	RKKSVNMTECVPVPS CCCCCCCEEEEECCC	22.49	28634298
95	Ubiquitination	KIKALRAKTNTYIKT EEEEEEECCCCEEEC	35.55	27667366
96	Phosphorylation	IKALRAKTNTYIKTP EEEEEECCCCEEECC	31.63	28152594
98	Phosphorylation	ALRAKTNTYIKTPVR EEEECCCCEEECCCC	31.68	28152594
99	Phosphorylation	LRAKTNTYIKTPVRG EEECCCCEEECCCCC	11.51	28152594
101	Ubiquitination	AKTNTYIKTPVRGEE ECCCCEEECCCCCCC	36.04	-
102	Phosphorylation	KTNTYIKTPVRGEEP CCCCEEECCCCCCCC	19.91	28555341
179	Ubiquitination	VGLVVGPKGATIKRI EEEEECCCCHHHHHH	56.07	32142685
182	Phosphorylation	VVGPKGATIKRIQQQ EECCCCHHHHHHHHC	35.38	-
192	Phosphorylation	RIQQQTHTYIVTPSR HHHHCCCEEEECCCC	20.52	29759185
193	Phosphorylation	IQQQTHTYIVTPSRD HHHCCCEEEECCCCC	5.93	27642862
196	Phosphorylation	QTHTYIVTPSRDKEP CCCEEEECCCCCCCC	13.14	29759185
201	Ubiquitination	IVTPSRDKEPVFEVT EECCCCCCCCCEEEE	63.91	22817900
201 (in isoform 1)	Ubiquitination	-	63.91	21906983
271	Phosphorylation	LWSKPTPSITPTPGR CCCCCCCCCCCCCCC	41.39	29255136
273	Phosphorylation	SKPTPSITPTPGRKP CCCCCCCCCCCCCCC	26.00	29255136
275	Phosphorylation	PTPSITPTPGRKPFS CCCCCCCCCCCCCCC	29.71	29255136
288	Phosphorylation	FSSYRNDSSSSLGSA CCCCCCCCCCCCCCC	35.35	27732954
289	Phosphorylation	SSYRNDSSSSLGSAS CCCCCCCCCCCCCCC	27.15	27732954
290	Phosphorylation	SYRNDSSSSLGSAST CCCCCCCCCCCCCCC	33.27	27732954
291	Phosphorylation	YRNDSSSSLGSASTD CCCCCCCCCCCCCCC	38.40	27732954
294	Phosphorylation	DSSSSLGSASTDSYF CCCCCCCCCCCCCCC	25.08	27732954
296	Phosphorylation	SSSLGSASTDSYFGG CCCCCCCCCCCCCCC	34.15	27732954
297	Phosphorylation	SSLGSASTDSYFGGG CCCCCCCCCCCCCCC	28.78	27732954
299	Phosphorylation	LGSASTDSYFGGGTS CCCCCCCCCCCCCCC	23.58	27732954
300	Phosphorylation	GSASTDSYFGGGTSS CCCCCCCCCCCCCCH	14.73	27732954
305	Phosphorylation	DSYFGGGTSSSAAAT CCCCCCCCCHHHHHH	28.80	27732954
306	Phosphorylation	SYFGGGTSSSAAATQ CCCCCCCCHHHHHHH	26.10	27732954
307	Phosphorylation	YFGGGTSSSAAATQR CCCCCCCHHHHHHHH	24.67	27732954
308	Phosphorylation	FGGGTSSSAAATQRL CCCCCCHHHHHHHHH	22.99	27732954
436	Phosphorylation	HRRLHPGTSCPRLSP ECCCCCCCCCCCCCC	31.44	28348404
437	Phosphorylation	RRLHPGTSCPRLSPP CCCCCCCCCCCCCCC	28.21	24961811
442	Phosphorylation	GTSCPRLSPPLHMAP CCCCCCCCCCCCCCC	26.25	30266825
462	Phosphorylation	HLARRVRSDPGGGGL HHHHHCCCCCCCCHH	45.35	22817900
495	Phosphorylation	SDTSGSSSSSSSSSS CCCCCCCCCCCCCCC	35.62	-
496	Phosphorylation	DTSGSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
497	Phosphorylation	TSGSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
498	Phosphorylation	SGSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
499	Phosphorylation	GSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
500	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
501	Phosphorylation	SSSSSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	-
502	Phosphorylation	SSSSSSSSSSSSSSG CCCCCCCCCCCCCCC	35.87	-
503	Phosphorylation	SSSSSSSSSSSSSGL CCCCCCCCCCCCCCC	35.87	-
504	Phosphorylation	SSSSSSSSSSSSGLR CCCCCCCCCCCCCCC	35.87	-
505	Phosphorylation	SSSSSSSSSSSGLRR CCCCCCCCCCCCCCC	35.87	-
550	Phosphorylation	ANRICEKSEPECPVC HHHHHHCCCCCCCCC	35.77	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEX3B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
462	S	Phosphorylation	Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.	18779327

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEX3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
1433E_HUMAN	YWHAE	physical	18779327
1433G_HUMAN	YWHAG	physical	18779327
1433B_HUMAN	YWHAB	physical	18779327
1433F_HUMAN	YWHAH	physical	18779327
1433Z_HUMAN	YWHAZ	physical	18779327
PABP1_HUMAN	PABPC1	physical	18779327
AGO1_HUMAN	AGO1	physical	18779327
SPN1_HUMAN	SNUPN	physical	24326307
SUZ12_HUMAN	SUZ12	physical	27338022

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.