dbPTM

PRP31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PRP31_HUMAN
UniProt AC	Q8WWY3
Protein Name	U4/U6 small nuclear ribonucleoprotein Prp31
Gene Name	PRPF31
Organism	Homo sapiens (Human).
Sequence Length	499
Subcellular Localization	Nucleus . Nucleus speckle . Nucleus, Cajal body . Predominantly found in speckles and in Cajal bodies.
Protein Description	Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 11867543]
Protein Sequence	MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLSGDSVKTIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVEIENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILTNATIMVVSVTASTTQGQQLSEEELERLEEACDMALELNASKHRIYEYVESRMSFIAPNLSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYHSDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEPPPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDLGFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTASSVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGLMST

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLADELLA ------CCHHHHHHH	32.06	28464451
23	Phosphorylation	EEEEGGSYGEEEEEP HHHCCCCCCCCCCCC	31.65	28464451
53	2-Hydroxyisobutyrylation	DSVKTIAKLWDSKMF CHHHHHHHHHCCHHH	46.38	-
53	Ubiquitination	DSVKTIAKLWDSKMF CHHHHHHHHHCCHHH	46.38	-
58	Ubiquitination	IAKLWDSKMFAEIMM HHHHHCCHHHHHHHH	35.25	32015554
70	Phosphorylation	IMMKIEEYISKQAKA HHHHHHHHHHHHCHH	9.56	-
73	Ubiquitination	KIEEYISKQAKASEV HHHHHHHHHCHHHHH	44.72	27667366
73	Acetylation	KIEEYISKQAKASEV HHHHHHHHHCHHHHH	44.72	25953088
76	Ubiquitination	EYISKQAKASEVMGP HHHHHHCHHHHHCCC	50.37	-
81	Sulfoxidation	QAKASEVMGPVEAAP HCHHHHHCCCCCCCC	4.39	21406390
90	Phosphorylation	PVEAAPEYRVIVDAN CCCCCCCEEEEEECC	14.77	-
140	Ubiquitination	LDYIRTVKELGNSLD HHHHHHHHHHHHHHH	46.76	29967540
140	2-Hydroxyisobutyrylation	LDYIRTVKELGNSLD HHHHHHHHHHHHHHH	46.76	-
145	Phosphorylation	TVKELGNSLDKCKNN HHHHHHHHHHHHCCC	35.83	27067055
148	Ubiquitination	ELGNSLDKCKNNENL HHHHHHHHHCCCHHH	53.02	29967540
201	Ubiquitination	ALELNASKHRIYEYV HHHHCCCHHHHHHHH	34.20	29901268
205	Phosphorylation	NASKHRIYEYVESRM CCCHHHHHHHHHHHH	10.93	27273156
207	Phosphorylation	SKHRIYEYVESRMSF CHHHHHHHHHHHHCH	7.79	28152594
210	Phosphorylation	RIYEYVESRMSFIAP HHHHHHHHHHCHHCC	24.20	28152594
239	Phosphorylation	MGVAGGLTNLSKMPA HCHHCCCCCHHCCCC	37.07	21406692
242	Phosphorylation	AGGLTNLSKMPACNI HCCCCCHHCCCCCCE	29.04	21406692
273	Phosphorylation	SVLPHTGYIYHSDIV CCCCCCCEEECHHHH	10.24	17360941
275	Phosphorylation	LPHTGYIYHSDIVQS CCCCCEEECHHHHHH	6.18	22817900
298	Ubiquitination	AARLVAAKCTLAARV HHHHHHHHHHHHHCC	20.29	-
298	Sumoylation	AARLVAAKCTLAARV HHHHHHHHHHHHHCC	20.29	-
298	Ubiquitination	AARLVAAKCTLAARV HHHHHHHHHHHHHCC	20.29	29967540
298	Acetylation	AARLVAAKCTLAARV HHHHHHHHHHHHHCC	20.29	25953088
298	Sumoylation	AARLVAAKCTLAARV HHHHHHHHHHHHHCC	20.29	-
307	Phosphorylation	TLAARVDSFHESTEG HHHHCCCCCHHCCCC	26.16	29507054
321	Ubiquitination	GKVGYELKDEIERKF CCCCCCCHHHHHHHH	41.18	29967540
321	Ubiquitination	GKVGYELKDEIERKF CCCCCCCHHHHHHHH	41.18	-
321	Sumoylation	GKVGYELKDEIERKF CCCCCCCHHHHHHHH	41.18	-
321	Sumoylation	GKVGYELKDEIERKF CCCCCCCHHHHHHHH	41.18	-
327	Sumoylation	LKDEIERKFDKWQEP CHHHHHHHHCCCCCC	45.16	-
327	Sumoylation	LKDEIERKFDKWQEP CHHHHHHHHCCCCCC	45.16	-
330	Ubiquitination	EIERKFDKWQEPPPV HHHHHHCCCCCCCCC	54.64	29967540
338	Ubiquitination	WQEPPPVKQVKPLPA CCCCCCCCCCCCCCC	55.96	33845483
338	Sumoylation	WQEPPPVKQVKPLPA CCCCCCCCCCCCCCC	55.96	-
338	Sumoylation	WQEPPPVKQVKPLPA CCCCCCCCCCCCCCC	55.96	-
341	Acetylation	PPPVKQVKPLPAPLD CCCCCCCCCCCCCCC	38.04	23236377
341	Acetylation	PPPVKQVKPLPAPLD CCCCCCCCCCCCCCC	38.04	-
369	Phosphorylation	MKERLGLTEIRKQAN HHHHHCCHHHHHHHH	27.80	28555341
379	Phosphorylation	RKQANRMSFGEIEED HHHHHHCCCHHCCCH	27.19	21712546
388	Phosphorylation	GEIEEDAYQEDLGFS HHCCCHHHHHHHCCC	25.42	28674151
395	Phosphorylation	YQEDLGFSLGHLGKS HHHHHCCCHHHCCCC	31.48	26074081
401	Ubiquitination	FSLGHLGKSGSGRVR CCHHHCCCCCCCCCC	58.99	32015554
402	Phosphorylation	SLGHLGKSGSGRVRQ CHHHCCCCCCCCCCH	36.07	26074081
404	Phosphorylation	GHLGKSGSGRVRQTQ HHCCCCCCCCCCHHH	30.43	26074081
410	Phosphorylation	GSGRVRQTQVNEATK CCCCCCHHHHHHHHH	24.74	26074081
416	Phosphorylation	QTQVNEATKARISKT HHHHHHHHHHHHHHH	21.03	21406692
417	Ubiquitination	TQVNEATKARISKTL HHHHHHHHHHHHHHH	42.59	-
417	Sumoylation	TQVNEATKARISKTL HHHHHHHHHHHHHHH	42.59	-
417 (in isoform 1)	Ubiquitination	-	42.59	21890473
417	Sumoylation	TQVNEATKARISKTL HHHHHHHHHHHHHHH	42.59	-
417	Ubiquitination	TQVNEATKARISKTL HHHHHHHHHHHHHHH	42.59	22817900
417	Acetylation	TQVNEATKARISKTL HHHHHHHHHHHHHHH	42.59	25953088
421	Phosphorylation	EATKARISKTLQRTL HHHHHHHHHHHHHHH	17.65	22798277
422	Sumoylation	ATKARISKTLQRTLQ HHHHHHHHHHHHHHH	51.38	-
422	Sumoylation	ATKARISKTLQRTLQ HHHHHHHHHHHHHHH	51.38	-
422	Ubiquitination	ATKARISKTLQRTLQ HHHHHHHHHHHHHHH	51.38	22817900
423	Phosphorylation	TKARISKTLQRTLQK HHHHHHHHHHHHHHH	22.72	22798277
430 (in isoform 1)	Ubiquitination	-	47.88	21890473
430	Sumoylation	TLQRTLQKQSVVYGG HHHHHHHHCCEEECC	47.88	-
430	Ubiquitination	TLQRTLQKQSVVYGG HHHHHHHHCCEEECC	47.88	22817900
430	Ubiquitination	TLQRTLQKQSVVYGG HHHHHHHHCCEEECC	47.88	-
430	Sumoylation	TLQRTLQKQSVVYGG HHHHHHHHCCEEECC	47.88	-
432	Phosphorylation	QRTLQKQSVVYGGKS HHHHHHCCEEECCCC	22.15	23927012
435	Phosphorylation	LQKQSVVYGGKSTIR HHHCCEEECCCCEEE	20.29	20164059
438	Methylation	QSVVYGGKSTIRDRS CCEEECCCCEEECCC	39.81	30591561
438	Acetylation	QSVVYGGKSTIRDRS CCEEECCCCEEECCC	39.81	25953088
438	Ubiquitination	QSVVYGGKSTIRDRS CCEEECCCCEEECCC	39.81	32015554
439	Phosphorylation	SVVYGGKSTIRDRSS CEEECCCCEEECCCC	32.13	23401153
440	Phosphorylation	VVYGGKSTIRDRSSG EEECCCCEEECCCCC	24.42	23401153
445	Phosphorylation	KSTIRDRSSGTASSV CCEEECCCCCCCCEE	37.09	23927012
446	Phosphorylation	STIRDRSSGTASSVA CEEECCCCCCCCEEE	40.85	23927012
448	Phosphorylation	IRDRSSGTASSVAFT EECCCCCCCCEEEEE	25.89	23927012
450	Phosphorylation	DRSSGTASSVAFTPL CCCCCCCCEEEEEEC	25.78	23927012
451	Phosphorylation	RSSGTASSVAFTPLQ CCCCCCCEEEEEECC	18.27	23927012
455	Phosphorylation	TASSVAFTPLQGLEI CCCEEEEEECCCCEE	17.22	23927012
470	Acetylation	VNPQAAEKKVAEANQ CCHHHHHHHHHHHHH	48.06	25953088
470	Ubiquitination	VNPQAAEKKVAEANQ CCHHHHHHHHHHHHH	48.06	32015554
471	Ubiquitination	NPQAAEKKVAEANQK CHHHHHHHHHHHHHH	37.88	-
471	Sumoylation	NPQAAEKKVAEANQK CHHHHHHHHHHHHHH	37.88	28112733
478 (in isoform 1)	Ubiquitination	-	48.33	21890473
478	Ubiquitination	KVAEANQKYFSSMAE HHHHHHHHHHHHHHH	48.33	22817900
478	Sumoylation	KVAEANQKYFSSMAE HHHHHHHHHHHHHHH	48.33	28112733
478	Sumoylation	KVAEANQKYFSSMAE HHHHHHHHHHHHHHH	48.33	-
478	Ubiquitination	KVAEANQKYFSSMAE HHHHHHHHHHHHHHH	48.33	-
479	Phosphorylation	VAEANQKYFSSMAEF HHHHHHHHHHHHHHH	10.03	20068231
481	Phosphorylation	EANQKYFSSMAEFLK HHHHHHHHHHHHHHH	19.00	20068231
482	Phosphorylation	ANQKYFSSMAEFLKV HHHHHHHHHHHHHHH	16.47	20068231
488	Ubiquitination	SSMAEFLKVKGEKSG HHHHHHHHHHCCCCC	47.42	32015554
490	Ubiquitination	MAEFLKVKGEKSGLM HHHHHHHHCCCCCCC	60.82	-
493	Ubiquitination	FLKVKGEKSGLMST- HHHHHCCCCCCCCC-	59.50	-
494	Phosphorylation	LKVKGEKSGLMST-- HHHHCCCCCCCCC--	32.62	24732914
498	Phosphorylation	GEKSGLMST------ CCCCCCCCC------	35.69	24732914
499	Phosphorylation	EKSGLMST------- CCCCCCCC-------	28.76	24732914

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PRP31_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PRP31_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PRP31_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTBL1_HUMAN	CTNNBL1	physical	21385873
IMA1_HUMAN	KPNA2	physical	21385873
IMA5_HUMAN	KPNA1	physical	21385873
NH2L1_HUMAN	NHP2L1	physical	16723661
PPIH_HUMAN	PPIH	physical	16723661
PRPF3_HUMAN	PRPF3	physical	16723661
PRP4_HUMAN	PRPF4	physical	16723661
PRP31_HUMAN	PRPF31	physical	16723661
PRP6_HUMAN	PRPF6	physical	16723661
PRP6_HUMAN	PRPF6	physical	22939629
SNUT1_HUMAN	SART1	physical	22939629
SF3B1_HUMAN	SF3B1	physical	22939629
SF3B3_HUMAN	SF3B3	physical	22939629
SYF1_HUMAN	XAB2	physical	22939629
SF3A1_HUMAN	SF3A1	physical	22939629
SF3A3_HUMAN	SF3A3	physical	22939629
RU2A_HUMAN	SNRPA1	physical	22939629
RU2B_HUMAN	SNRPB2	physical	22939629
SF3A2_HUMAN	SF3A2	physical	22939629
TFDP1_HUMAN	TFDP1	physical	22939629
RENT2_HUMAN	UPF2	physical	22939629
STRN3_HUMAN	STRN3	physical	22939629
RBM25_HUMAN	RBM25	physical	22365833
PHF5A_HUMAN	PHF5A	physical	22365833
PRP6_HUMAN	PRPF6	physical	22365833
RBM4_HUMAN	RBM4	physical	22365833
HNRH2_HUMAN	HNRNPH2	physical	22365833
RACK1_HUMAN	GNB2L1	physical	22365833
CDA7L_HUMAN	CDCA7L	physical	25416956
ZN250_HUMAN	ZNF250	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
TSG10_HUMAN	TSGA10	physical	25416956
ZN587_HUMAN	ZNF587	physical	25416956
C1QT1_HUMAN	C1QTNF1	physical	25416956
ADIP_HUMAN	SSX2IP	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
PRIC1_HUMAN	PRICKLE1	physical	25416956
MIPO1_HUMAN	MIPOL1	physical	25416956
RBY1F_HUMAN	RBMY1F	physical	25416956
KCTD6_HUMAN	KCTD6	physical	25416956
KHDR2_HUMAN	KHDRBS2	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
LURA1_HUMAN	LURAP1	physical	25416956
CD2B2_HUMAN	CD2BP2	physical	26344197
DDX23_HUMAN	DDX23	physical	26344197
U5S1_HUMAN	EFTUD2	physical	26344197
PRP4_HUMAN	PRPF4	physical	26344197
PRP8_HUMAN	PRPF8	physical	26344197
SNUT1_HUMAN	SART1	physical	26344197
U520_HUMAN	SNRNP200	physical	26344197
SART3_HUMAN	SART3	physical	28514442
DIEXF_HUMAN	DIEXF	physical	28514442
ZN622_HUMAN	ZNF622	physical	28514442
STPAP_HUMAN	TUT1	physical	28514442
FBRS_HUMAN	FBRS	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
MTHR_HUMAN	MTHFR	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442
WBP4_HUMAN	WBP4	physical	28514442
ARI1_HUMAN	ARIH1	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
RUXG_HUMAN	SNRPG	physical	27173435
SMD1_HUMAN	SNRPD1	physical	27173435
RSMB_HUMAN	SNRPB	physical	27173435
SMD2_HUMAN	SNRPD2	physical	27173435
RS19_HUMAN	RPS19	physical	27173435
OSBL1_HUMAN	OSBPL1A	physical	27173435
SMD3_HUMAN	SNRPD3	physical	27173435
TT21B_HUMAN	TTC21B	physical	27173435
IFT46_HUMAN	IFT46	physical	27173435
UBE2N_HUMAN	UBE2N	physical	27173435
RANB9_HUMAN	RANBP9	physical	27173435
NH2L1_HUMAN	NHP2L1	physical	26275778
ZNHI3_HUMAN	ZNHIT3	physical	26275778
NUFP1_HUMAN	NUFIP1	physical	26275778
RUVB1_HUMAN	RUVBL1	physical	26275778
SMN_HUMAN	SMN1	physical	26275778

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
600138	Retinitis pigmentosa 11 (RP11)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PRP31_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379 AND THR-455, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-448 AND THR-455, ANDMASS SPECTROMETRY.	18669648 [Abstract]