| UniProt ID | WBP4_HUMAN | |
|---|---|---|
| UniProt AC | O75554 | |
| Protein Name | WW domain-binding protein 4 | |
| Gene Name | WBP4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 376 | |
| Subcellular Localization | Nucleus . Nucleus speckle . | |
| Protein Description | Involved in pre-mRNA splicing as a component of the spliceosome. [PubMed: 9724750] | |
| Protein Sequence | MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIPPTSTSNQQKEKKEKKKRKKDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFIPHTSDLPSSKVNENSLGTLDESKSSDSHSDSDGEQEAEEGGVSTETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVDLELPSTENEYVSTSEADGGGEPKVVFKEKTVTSLGVMADGVAPVFKKRRTENGKSRNLRQRGDDQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Methylation | --MADYWKSQPKKFC --CCCHHHHCCCHHC | 32.74 | 115978719 | |
| 11 | Acetylation | YWKSQPKKFCDYCKC HHHHCCCHHCCCCCC | 58.89 | 25953088 | |
| 37 | Ubiquitination | HERGKNHKENVAKRI HHHCCCHHHHHHHHH | 61.45 | 24816145 | |
| 51 | Phosphorylation | ISEIKQKSLDKAKEE HHHHHHHHHHHHHHH | 39.03 | - | |
| 60 | Ubiquitination | DKAKEEEKASKEFAA HHHHHHHHHHHHHHH | 62.33 | 23000965 | |
| 62 | Phosphorylation | AKEEEKASKEFAAME HHHHHHHHHHHHHHH | 43.73 | 27251275 | |
| 63 | Ubiquitination | KEEEKASKEFAAMEA HHHHHHHHHHHHHHH | 62.81 | 23000965 | |
| 68 | Ubiquitination | ASKEFAAMEAAALKA HHHHHHHHHHHHHHH | 3.02 | 24816145 | |
| 76 | Phosphorylation | EAAALKAYQEDLKRL HHHHHHHHHHHHHHH | 15.73 | 27642862 | |
| 91 | Ubiquitination | GLESEILEPSITPVT CCCCHHCCCCCCCCC | 42.54 | 23000965 | |
| 94 | Ubiquitination | SEILEPSITPVTSTI CHHCCCCCCCCCCCC | 8.05 | 23000965 | |
| 98 | Phosphorylation | EPSITPVTSTIPPTS CCCCCCCCCCCCCCC | 22.74 | - | |
| 100 | Phosphorylation | SITPVTSTIPPTSTS CCCCCCCCCCCCCCC | 28.30 | - | |
| 104 | Phosphorylation | VTSTIPPTSTSNQQK CCCCCCCCCCCHHHH | 39.00 | - | |
| 105 | Phosphorylation | TSTIPPTSTSNQQKE CCCCCCCCCCHHHHH | 35.30 | - | |
| 106 | Phosphorylation | STIPPTSTSNQQKEK CCCCCCCCCHHHHHH | 33.89 | 22210691 | |
| 107 | Phosphorylation | TIPPTSTSNQQKEKK CCCCCCCCHHHHHHH | 32.20 | 22210691 | |
| 120 | Ubiquitination | KKEKKKRKKDPSKGR HHHHHHHCCCCCCCC | 71.10 | 24816145 | |
| 151 | Ubiquitination | ISGASQWEKPEGFQG CCCCCCCCCCCCCCC | 51.61 | 24816145 | |
| 184 | Phosphorylation | GFTYYYNTETGESRW CCEEEEECCCCCCCC | 20.85 | - | |
| 213 | Phosphorylation | SSKVNENSLGTLDES CCCCCCCCCCCCCCC | 23.23 | 25159151 | |
| 216 | Phosphorylation | VNENSLGTLDESKSS CCCCCCCCCCCCCCC | 36.01 | 25137130 | |
| 220 | Phosphorylation | SLGTLDESKSSDSHS CCCCCCCCCCCCCCC | 37.19 | 28355574 | |
| 222 | Phosphorylation | GTLDESKSSDSHSDS CCCCCCCCCCCCCCC | 48.97 | 23898821 | |
| 223 | Phosphorylation | TLDESKSSDSHSDSD CCCCCCCCCCCCCCC | 47.04 | 25137130 | |
| 225 | Phosphorylation | DESKSSDSHSDSDGE CCCCCCCCCCCCCCH | 27.17 | 25022875 | |
| 227 | Phosphorylation | SKSSDSHSDSDGEQE CCCCCCCCCCCCHHH | 42.64 | 23898821 | |
| 229 | Phosphorylation | SSDSHSDSDGEQEAE CCCCCCCCCCHHHHH | 51.00 | 23898821 | |
| 241 | Phosphorylation | EAEEGGVSTETEKPK HHHHCCCCCCCCCCC | 24.65 | 21406692 | |
| 242 | Phosphorylation | AEEGGVSTETEKPKI HHHCCCCCCCCCCCC | 44.51 | 21406692 | |
| 244 | Phosphorylation | EGGVSTETEKPKIKF HCCCCCCCCCCCCCC | 49.77 | 26074081 | |
| 258 | Phosphorylation | FKEKNKNSDGGSDPE CCCCCCCCCCCCCHH | 38.96 | 30576142 | |
| 262 | Phosphorylation | NKNSDGGSDPETQKE CCCCCCCCCHHHHHH | 56.36 | 29255136 | |
| 266 | Phosphorylation | DGGSDPETQKEKSIQ CCCCCHHHHHHHHHH | 50.78 | 29255136 | |
| 277 | Phosphorylation | KSIQKQNSLGSNEEK HHHHHHHHCCCCHHH | 31.45 | 25159151 | |
| 280 | Phosphorylation | QKQNSLGSNEEKSKT HHHHHCCCCHHHHHH | 46.49 | 29978859 | |
| 290 | Ubiquitination | EKSKTLKKSNPYGEW HHHHHHHHCCCCCCH | 59.59 | 29967540 | |
| 294 | Phosphorylation | TLKKSNPYGEWQEIK HHHHCCCCCCHHHHH | 31.74 | 28796482 | |
| 301 | Sumoylation | YGEWQEIKQEVESHE CCCHHHHHHHHHHCC | 39.39 | - | |
| 306 | Phosphorylation | EIKQEVESHEEVDLE HHHHHHHHCCCEEEE | 41.18 | 28985074 | |
| 323 | Phosphorylation | STENEYVSTSEADGG CCCCCEEECCCCCCC | 25.88 | 25159151 | |
| 343 | O-linked_Glycosylation | VFKEKTVTSLGVMAD EEEEEEECEEEEECC | 24.38 | 31373491 | |
| 348 | Sulfoxidation | TVTSLGVMADGVAPV EECEEEEECCCCHHH | 2.39 | 21406390 | |
| 357 | Acetylation | DGVAPVFKKRRTENG CCCHHHHHCCCCCCC | 45.67 | 25953088 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WBP4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WBP4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WBP4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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