PRIC1_HUMAN - dbPTM
PRIC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRIC1_HUMAN
UniProt AC Q96MT3
Protein Name Prickle-like protein 1
Gene Name PRICKLE1
Organism Homo sapiens (Human).
Sequence Length 831
Subcellular Localization Nucleus membrane . Cytoplasm, cytosol . A smaller amount is detected in the cytosol.
Protein Description Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor..
Protein Sequence MPLEMEPKMSKLAFGCQRSSTSDDDSGCALEEYAWVPPGLRPEQIQLYFACLPEEKVPYVNSPGEKHRIKQLLYQLPPHDNEVRYCQSLSEEEKKELQVFSAQRKKEALGRGTIKLLSRAVMHAVCEQCGLKINGGEVAVFASRAGPGVCWHPSCFVCFTCNELLVDLIYFYQDGKIHCGRHHAELLKPRCSACDEIIFADECTEAEGRHWHMKHFCCLECETVLGGQRYIMKDGRPFCCGCFESLYAEYCETCGEHIGVDHAQMTYDGQHWHATEACFSCAQCKASLLGCPFLPKQGQIYCSKTCSLGEDVHASDSSDSAFQSARSRDSRRSVRMGKSSRSADQCRQSLLLSPALNYKFPGLSGNADDTLSRKLDDLSLSRQGTSFASEEFWKGRVEQETPEDPEEWADHEDYMTQLLLKFGDKSLFQPQPNEMDIRASEHWISDNMVKSKTELKQNNQSLASKKYQSDMYWAQSQDGLGDSAYGSHPGPASSRRLQELELDHGASGYNHDETQWYEDSLECLSDLKPEQSVRDSMDSLALSNITGASVDGENKPRPSLYSLQNFEEMETEDCEKMSNMGTLNSSMLHRSAESLKSLSSELCPEKILPEEKPVHLPVLRRSKSQSRPQQVKFSDDVIDNGNYDIEIRQPPMSERTRRRVYNFEERGSRSHHHRRRRSRKSRSDNALNLVTERKYSPKDRLRLYTPDNYEKFIQNKSAREIQAYIQNADLYGQYAHATSDYGLQNPGMNRFLGLYGEDDDSWCSSSSSSSDSEEEGYFLGQPIPQPRPQRFAYYTDDLSSPPSALPTPQFGQRTTKSKKKKGHKGKNCIIS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
21PhosphorylationFGCQRSSTSDDDSGC
CCCCCCCCCCCCCCC		37.10-
88PhosphorylationNEVRYCQSLSEEEKK
CHHHHHHCCCHHHHH		30.2427251275
301PhosphorylationLPKQGQIYCSKTCSL
CCCCCEEEECCCCCC		5.2530576142
305PhosphorylationGQIYCSKTCSLGEDV
CEEEECCCCCCCCCC		7.3427732954
307PhosphorylationIYCSKTCSLGEDVHA
EEECCCCCCCCCCCC		44.6427732954
315PhosphorylationLGEDVHASDSSDSAF
CCCCCCCCCCCCHHH		24.1324719451
317PhosphorylationEDVHASDSSDSAFQS
CCCCCCCCCCHHHHH		33.2827732954
318PhosphorylationDVHASDSSDSAFQSA
CCCCCCCCCHHHHHH		40.3424719451
320PhosphorylationHASDSSDSAFQSARS
CCCCCCCHHHHHHHH		32.6927732954
324PhosphorylationSSDSAFQSARSRDSR
CCCHHHHHHHHHHHH		21.1330576142
353PhosphorylationCRQSLLLSPALNYKF
HHHHHHHCHHHCCCC		14.2223403867
370PhosphorylationLSGNADDTLSRKLDD
CCCCCCHHHHHHHHH		27.4723403867
372PhosphorylationGNADDTLSRKLDDLS
CCCCHHHHHHHHHHC		29.4823403867
379PhosphorylationSRKLDDLSLSRQGTS
HHHHHHHCHHCCCCC		31.1523403867
381PhosphorylationKLDDLSLSRQGTSFA
HHHHHCHHCCCCCCC		21.1223403867
385PhosphorylationLSLSRQGTSFASEEF
HCHHCCCCCCCCHHH		16.6024719451
386PhosphorylationSLSRQGTSFASEEFW
CHHCCCCCCCCHHHH		26.1628857561
389PhosphorylationRQGTSFASEEFWKGR
CCCCCCCCHHHHCCC		35.3327251275
445PhosphorylationRASEHWISDNMVKSK
HHHHHCHHCCCCCCH		20.10-
451PhosphorylationISDNMVKSKTELKQN
HHCCCCCCHHHHHHH		33.1423909892
453PhosphorylationDNMVKSKTELKQNNQ
CCCCCCHHHHHHHHH		54.3523909892
461PhosphorylationELKQNNQSLASKKYQ
HHHHHHHHHHHHHHH		28.2023909892
464PhosphorylationQNNQSLASKKYQSDM
HHHHHHHHHHHHCHH		34.6723909892
467PhosphorylationQSLASKKYQSDMYWA
HHHHHHHHHCHHHHE		19.5826552605
469PhosphorylationLASKKYQSDMYWAQS
HHHHHHHCHHHHEEC		22.6626552605
472PhosphorylationKKYQSDMYWAQSQDG
HHHHCHHHHEECCCC		11.5526552605
476PhosphorylationSDMYWAQSQDGLGDS
CHHHHEECCCCCCCC		23.6126552605
483PhosphorylationSQDGLGDSAYGSHPG
CCCCCCCCCCCCCCC		22.9226552605
485PhosphorylationDGLGDSAYGSHPGPA
CCCCCCCCCCCCCCC		24.1026552605
487PhosphorylationLGDSAYGSHPGPASS
CCCCCCCCCCCCCCH		17.5226552605
493PhosphorylationGSHPGPASSRRLQEL
CCCCCCCCHHHHHEE		27.7526552605
494PhosphorylationSHPGPASSRRLQELE
CCCCCCCHHHHHEEE		24.4326552605
578PhosphorylationTEDCEKMSNMGTLNS
HHHHHHHHHHCCCCH		34.4322210691
582PhosphorylationEKMSNMGTLNSSMLH
HHHHHHCCCCHHHHH		16.4022210691
585PhosphorylationSNMGTLNSSMLHRSA
HHHCCCCHHHHHHCH		21.9027732954
586PhosphorylationNMGTLNSSMLHRSAE
HHCCCCHHHHHHCHH		25.0422210691
591PhosphorylationNSSMLHRSAESLKSL
CHHHHHHCHHHHHHH		26.1624719451
594PhosphorylationMLHRSAESLKSLSSE
HHHHCHHHHHHHCCC		40.5927732954
597PhosphorylationRSAESLKSLSSELCP
HCHHHHHHHCCCCCC		38.4825056879
599PhosphorylationAESLKSLSSELCPEK
HHHHHHHCCCCCCCC		28.9427732954
600PhosphorylationESLKSLSSELCPEKI
HHHHHHCCCCCCCCC		39.6225056879
622PhosphorylationHLPVLRRSKSQSRPQ
CHHHHCCCCCCCCCC		30.1724719451
624PhosphorylationPVLRRSKSQSRPQQV
HHHCCCCCCCCCCEE		34.3329514088
626PhosphorylationLRRSKSQSRPQQVKF
HCCCCCCCCCCEEEC		53.6829514088
643PhosphorylationDVIDNGNYDIEIRQP
CCCCCCCEEEEECCC		21.5027642862
653PhosphorylationEIRQPPMSERTRRRV
EECCCCCCHHHHHHC		29.6924719451
668PhosphorylationYNFEERGSRSHHHRR
CCHHHCCCCCHHHHH		36.5124719451
681PhosphorylationRRRRSRKSRSDNALN
HHHHHHHCHHHHHHH		35.5922617229
683PhosphorylationRRSRKSRSDNALNLV
HHHHHCHHHHHHHHH		42.1622617229
691PhosphorylationDNALNLVTERKYSPK
HHHHHHHHCCCCCHH		32.9923403867
695PhosphorylationNLVTERKYSPKDRLR
HHHHCCCCCHHHCEE		36.1029759185
696PhosphorylationLVTERKYSPKDRLRL
HHHCCCCCHHHCEEE		28.6329759185
709PhosphorylationRLYTPDNYEKFIQNK
EEECCCCHHHHHHCC		28.0729759185
711UbiquitinationYTPDNYEKFIQNKSA
ECCCCHHHHHHCCCH		37.09-
716UbiquitinationYEKFIQNKSAREIQA
HHHHHHCCCHHHHHH		29.17-
828MethylationKGHKGKNCIIS----
CCCCCCCCCCC----		3.13-
828FarnesylationKGHKGKNCIIS----
CCCCCCCCCCC----		3.1314645515
828FarnesylationKGHKGKNCIIS----
CCCCCCCCCCC----		3.1314645515
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRIC1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRIC1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRIC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DVL3_HUMANDVL3physical
17030191
TANC1_RATTanc1physical
25763846
RL23_RATRpl23physical
25763846
RL4_RATRpl4physical
25763846
RS26_RATRps26physical
25763846
TBB4B_RATTubb4bphysical
25763846
TBB5_RATTubb5physical
25763846
USP9X_HUMANUSP9Xphysical
25763846
Drug and Disease Associations
Kegg Disease
H00810 Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (
OMIM Disease
612437Epilepsy, progressive myoclonic 1B (EPM1B)
182940Neural tube defects (NTD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRIC1_HUMAN

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Related Literatures of Post-Translational Modification
Prenylation
ReferencePubMed
"Towards complete sets of farnesylated and geranylgeranylatedproteins.";
Maurer-Stroh S., Koranda M., Benetka W., Schneider G., Sirota F.L.,Eisenhaber F.;
PLoS Comput. Biol. 3:634-648(2007).
Cited for: ISOPRENYLATION AT CYS-828.
"REST/NRSF-interacting LIM domain protein, a putative nucleartranslocation receptor.";
Shimojo M., Hersh L.B.;
Mol. Cell. Biol. 23:9025-9031(2003).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ISOPRENYLATION ATCYS-828, MUTAGENESIS OF 828-CYS--SER-831, SUBCELLULAR LOCATION, ANDINTERACTION WITH REST.

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