RL4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL4_RAT
• UniProt AC: P50878
• Protein Name: 60S ribosomal protein L4
• Gene Name: Rpl4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 421
• Protein Sequence: MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHCVEEVPELPLVVEDKVESYKKTKEAVQLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMMNTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVKKLEAAAAALAAKSEKIVPEKGAGDKKPAVGKKGKKPVDAKKLKKPAGKKVVTKKPAEKKPTTEEKKSAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MACARPLIS ------CCCCCCCEE	8.83	-
9	Phosphorylation	ACARPLISVYSEKGE CCCCCCEEEECCCCC	23.76	23984901
12	Phosphorylation	RPLISVYSEKGESSG CCCEEEECCCCCCCC	30.58	23984901
14	Acetylation	LISVYSEKGESSGKN CEEEECCCCCCCCCC	63.14	22902405
23	Phosphorylation	ESSGKNVTLPAVFKA CCCCCCCCCCEEECC	36.10	23984901
29	Acetylation	VTLPAVFKAPIRPDI CCCCEEECCCCCHHH	46.80	22902405
66	Phosphorylation	GHQTSAESWGTGRAV CCCCCHHHHCCCCCE	30.44	23984901
69	Phosphorylation	TSAESWGTGRAVARI CCHHHHCCCCCEEEC	19.75	23984901
87	Phosphorylation	RGGGTHRSGQGAFGN CCCCCCCCCCCCCCC	28.06	23984901
97	Methylation	GAFGNMCRGGRMFAP CCCCCCCCCCCCCCC	39.57	16186615
100	Methylation	GNMCRGGRMFAPTKT CCCCCCCCCCCCHHH	21.62	26494251
106	Acetylation	GRMFAPTKTWRRWHR CCCCCCHHHHHHHHH	45.06	22902405
172	Acetylation	KEAVQLLKKLKAWND HHHHHHHHHHHHHHH	65.73	22902405
181	Acetylation	LKAWNDIKKVYASQR HHHHHHHHHHHHHHH	38.76	22902405
233	Phosphorylation	GITLLNVSKLNILKL CEEEEEHHHCCEEEC	30.28	23984901
239	Acetylation	VSKLNILKLAPGGHV HHHCCEEECCCCCCH	38.51	22902405
253	Phosphorylation	VGRFCIWTESAFRKL HHHEEEECHHHHHHH	10.51	23984901
255	Phosphorylation	RFCIWTESAFRKLDE HEEEECHHHHHHHHH	25.90	23984901
259	Succinylation	WTESAFRKLDELYGT ECHHHHHHHHHHHHH	54.56	26843850
259	Acetylation	WTESAFRKLDELYGT ECHHHHHHHHHHHHH	54.56	-
266	Phosphorylation	KLDELYGTWRKAASL HHHHHHHHHHHHHHC	14.45	23984901
272	Phosphorylation	GTWRKAASLKSNYNL HHHHHHHHCCCCCCC	40.98	23984901
275	Phosphorylation	RKAASLKSNYNLPMH HHHHHCCCCCCCCHH	50.25	23984901
277	Phosphorylation	AASLKSNYNLPMHKM HHHCCCCCCCCHHHH	25.76	23984901
287	Phosphorylation	PMHKMMNTDLSRILK CHHHHHCCCHHHHHC	22.03	23984901
290	Phosphorylation	KMMNTDLSRILKSPE HHHCCCHHHHHCCHH	21.78	22673903
295	Phosphorylation	DLSRILKSPEIQRAL CHHHHHCCHHHHHHH	25.07	23712012
300	Citrullination	LKSPEIQRALRAPRK HCCHHHHHHHHCCHH	41.05	-
300	Citrullination	LKSPEIQRALRAPRK HCCHHHHHHHHCCHH	41.05	-
333	Acetylation	LKLNPYAKTMRRNTI HHHCHHHHHHHHHHH	36.69	-
353	Acetylation	NHKLRVKKLEAAAAA HCCCHHHHHHHHHHH	49.02	-
364	Acetylation	AAAALAAKSEKIVPE HHHHHHHHHCCCCCC	54.24	-
364	Ubiquitination	AAAALAAKSEKIVPE HHHHHHHHHCCCCCC	54.24	-
365	Phosphorylation	AAALAAKSEKIVPEK HHHHHHHHCCCCCCC	39.12	23984901
367	Acetylation	ALAAKSEKIVPEKGA HHHHHHCCCCCCCCC	56.97	22902405
383	Acetylation	DKKPAVGKKGKKPVD CCCCCCCCCCCCCCC	52.32	22902405
384	Acetylation	KKPAVGKKGKKPVDA CCCCCCCCCCCCCCH	70.77	22902405
405	Ubiquitination	AGKKVVTKKPAEKKP CCCCCCCCCCCCCCC	45.19	-
410	Ubiquitination	VTKKPAEKKPTTEEK CCCCCCCCCCCCHHH	67.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RL4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.