TANC1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TANC1_RAT
• UniProt AC: Q6F6B3
• Protein Name: Protein TANC1
• Gene Name: Tanc1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1849
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Largly colocalizes with SYP/synaptophysin, DLG1, DLG4 and GRIA1 at synaptic sites.
• Protein Description: May be a scaffold component in the postsynaptic density..
• Protein Sequence: MLKAVLKKSREGVKGSKKEAGGDFGSETPTLSSSGDSPVNSLSTTEDTYRVSLAKGVSMSLPSSPLLPRQSHLTQSRANKKSPGPVRKPKYVESPRVPGDPVMIPFREGSKPAEPIETEAKVDNEPSCSPAAQELLTRLGFLLGEGIPSATHITIEDKNEAMCTALSQGISPCSTLTSSTASPSTDSPCSTLNSCVSKTAANKSPCETISSPSSTLESKDSGIIATITSSSENDDRSGSSLEWNRDGSLRLGVQKGVLHDRRLDNCSPVAEEETTGSAESVLPKAESSAGDGPVPYSQSSGSLIMPRPNSVAATSSTKLEDLSYLDGQRNAPLRTSIRLPWHSTAGARFAPYKPQEILLKPLLFEVPSITTDSVFVGRDWLFQQIEENLRNTELAENRGAVVVGNVGFGKTAIISKLVALSCHGSRMRQVASSSPSSSLKTSDPTHDLPGTPLLSPSSSTSALSAARTPPGPGTVDSQRPREDAVKYLASRVVAYHYCQADNTYTCLVPEFVHSIATLLCRSHQLAAYRDLLIREPQLQSMLNLRSCVQDPVAAFKRGILEPLTNLRNEQKIPEEEYIILIDGLNEAEFHKPDHGDTLSSFITKIIPKFPPWLKLIVTVRADFQEIISTLPFVKLSLDDFPGNQDIHSDLHAYVQHRVHSSQDILSNISLNGKADAALIGKVSSRLVLRNLGSYLYLKLTLDLFQRGHLVIKSASYKVVPVSLSELYLLQCNMKFMTQSAFDRALPILNVALASLHPMTDEQIFQAINAGHIQGEQGWEDFQQKMEALSCFLIKKRDKTRMFCHPSFREWLVWRADGESTAFLCEPRNGHALLAFMFSRQESKLNRQQTVELGHHILKAHIFKGLSKKTGVSSSHPQALWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLTKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAAASMGHSAVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKLEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVQLLLDRGCDVNPNDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATFKPDILIILLQKLMEEGNVMYKKGKMKEAAQRYQYALRKFPREGPGEDMRPFNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPTNQEIKRLLARVEEECKQLQRNQQQKQQAPLPAPPNDSDNDEEAPASSLKDHFPIEEAEEEDTSSQEESISPTPRSQPPPSVPSPYIRNLQEGLQSKGRPASPQSWAGISKSLRETVAQPGLVMQPTKQAQIVKTNQHLGSGQSSMRNSNTKVQVSSQNPPPSPMPGRVSAAPAVSRNQHLEGTGPFSTGTGCGHFGDRLGPSQSLQLQRGESGTAYPLPSKVKAAERLLAHASVAVDMALPSQGGPVSCSDVRHPASLSSSGSSGSPSSSVKMSSSTSSLTSSSSVSDGFKAQGPDCRIRDRGTTQVQGGTAEHRPRNTPFMGIMDKIARFQQQVNPPSRSWHCPVTEGLLTNTATAAGLQTNSEKPALKPGGYCSQAKPCSVPPLGMGVHNGAQVKELEENKCQVPALCQDNRKTKGVPHLYPEGVSKQPLHVSTEAHRSHLTSAKPKRSFIESNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLKAVLKK -------CHHHHHHH	38.98	-
58	Phosphorylation	VSLAKGVSMSLPSSP EEECCCCCCCCCCCC	16.01	28432305
60	Phosphorylation	LAKGVSMSLPSSPLL ECCCCCCCCCCCCCC	29.62	27097102
63	Phosphorylation	GVSMSLPSSPLLPRQ CCCCCCCCCCCCCCC	50.29	27097102
64	Phosphorylation	VSMSLPSSPLLPRQS CCCCCCCCCCCCCCH	20.02	27097102
199	Phosphorylation	LNSCVSKTAANKSPC HHHHHCCCCCCCCCC	24.40	27097102
204	Phosphorylation	SKTAANKSPCETISS CCCCCCCCCCCCCCC	34.29	27097102
208	Phosphorylation	ANKSPCETISSPSST CCCCCCCCCCCCCCC	32.64	27097102
210	Phosphorylation	KSPCETISSPSSTLE CCCCCCCCCCCCCCC	43.55	28432305
211	Phosphorylation	SPCETISSPSSTLES CCCCCCCCCCCCCCC	25.58	28432305
213	Phosphorylation	CETISSPSSTLESKD CCCCCCCCCCCCCCC	37.59	28432305
214	Phosphorylation	ETISSPSSTLESKDS CCCCCCCCCCCCCCC	40.16	27097102
215	Phosphorylation	TISSPSSTLESKDSG CCCCCCCCCCCCCCC	38.59	27097102
218	Phosphorylation	SPSSTLESKDSGIIA CCCCCCCCCCCCEEE	44.89	27097102
221	Phosphorylation	STLESKDSGIIATIT CCCCCCCCCEEEEEE	35.31	30181290
226	Phosphorylation	KDSGIIATITSSSEN CCCCEEEEEEECCCC	17.87	30181290
239	Phosphorylation	ENDDRSGSSLEWNRD CCCCCCCCCCEECCC	32.75	27097102
240	Phosphorylation	NDDRSGSSLEWNRDG CCCCCCCCCEECCCC	33.56	27097102
267	Phosphorylation	DRRLDNCSPVAEEET CCCCCCCCCCCEECC	28.76	-
310	Phosphorylation	LIMPRPNSVAATSST EEECCCCCCCCCCCC	18.80	27097102
455	Phosphorylation	LPGTPLLSPSSSTSA CCCCCCCCCCCCCCH	30.34	-
858	Acetylation	ELGHHILKAHIFKGL HHHHHHHHHHHHHCC	37.00	22902405
1290	Phosphorylation	MEEGNVMYKKGKMKE HHCCCCCEECCCHHH	12.79	-
1429	Phosphorylation	LPAPPNDSDNDEEAP CCCCCCCCCCCCCCC	44.98	29779826
1438	Phosphorylation	NDEEAPASSLKDHFP CCCCCCHHHCHHCCC	34.83	23984901
1439	Phosphorylation	DEEAPASSLKDHFPI CCCCCHHHCHHCCCH	41.36	23984901
1454	Phosphorylation	EEAEEEDTSSQEESI HHHHCCCCCCCCCCC	33.29	22673903
1455	Phosphorylation	EAEEEDTSSQEESIS HHHCCCCCCCCCCCC	42.20	22673903
1456	Phosphorylation	AEEEDTSSQEESISP HHCCCCCCCCCCCCC	43.64	22673903
1460	Phosphorylation	DTSSQEESISPTPRS CCCCCCCCCCCCCCC	27.84	22673903
1462	Phosphorylation	SSQEESISPTPRSQP CCCCCCCCCCCCCCC	31.81	22673903
1464	Phosphorylation	QEESISPTPRSQPPP CCCCCCCCCCCCCCC	25.25	28689409
1487	Phosphorylation	NLQEGLQSKGRPASP HHHHHHHHCCCCCCH	41.96	27097102
1554	Phosphorylation	SSQNPPPSPMPGRVS CCCCCCCCCCCCCCC	39.34	22108457
1604	Phosphorylation	LQLQRGESGTAYPLP EEECCCCCCCCCCCC	44.24	28432305
1606	Phosphorylation	LQRGESGTAYPLPSK ECCCCCCCCCCCCHH	32.09	28432305
1649	Phosphorylation	SDVRHPASLSSSGSS HHCCCCCCCCCCCCC	32.98	25575281
1651	Phosphorylation	VRHPASLSSSGSSGS CCCCCCCCCCCCCCC	21.69	28432305
1652	Phosphorylation	RHPASLSSSGSSGSP CCCCCCCCCCCCCCC	43.97	28432305
1653	Phosphorylation	HPASLSSSGSSGSPS CCCCCCCCCCCCCCC	39.04	28432305
1655	Phosphorylation	ASLSSSGSSGSPSSS CCCCCCCCCCCCCCC	33.21	28432305
1656	Phosphorylation	SLSSSGSSGSPSSSV CCCCCCCCCCCCCCC	46.98	28432305
1658	Phosphorylation	SSSGSSGSPSSSVKM CCCCCCCCCCCCCEE	24.45	28432305
1660	Phosphorylation	SGSSGSPSSSVKMSS CCCCCCCCCCCEECC	36.62	28432305
1661	Phosphorylation	GSSGSPSSSVKMSSS CCCCCCCCCCEECCC	42.40	28432305
1662	Phosphorylation	SSGSPSSSVKMSSST CCCCCCCCCEECCCC	30.05	28432305
1666	Phosphorylation	PSSSVKMSSSTSSLT CCCCCEECCCCCCCC	18.54	25575281
1667	Phosphorylation	SSSVKMSSSTSSLTS CCCCEECCCCCCCCC	33.85	25575281
1668	Phosphorylation	SSVKMSSSTSSLTSS CCCEECCCCCCCCCC	25.63	28689409
1669	Phosphorylation	SVKMSSSTSSLTSSS CCEECCCCCCCCCCC	25.04	25575281
1670	Phosphorylation	VKMSSSTSSLTSSSS CEECCCCCCCCCCCC	25.87	25575281
1671	Phosphorylation	KMSSSTSSLTSSSSV EECCCCCCCCCCCCC	35.44	25575281
1673	Phosphorylation	SSSTSSLTSSSSVSD CCCCCCCCCCCCCCC	28.63	25575281
1674	Phosphorylation	SSTSSLTSSSSVSDG CCCCCCCCCCCCCCC	33.25	28689409
1675	Phosphorylation	STSSLTSSSSVSDGF CCCCCCCCCCCCCCC	22.77	28689409
1676	Phosphorylation	TSSLTSSSSVSDGFK CCCCCCCCCCCCCCC	34.23	25575281
1677	Phosphorylation	SSLTSSSSVSDGFKA CCCCCCCCCCCCCCC	27.82	25575281
1679	Phosphorylation	LTSSSSVSDGFKAQG CCCCCCCCCCCCCCC	33.68	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TANC1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TANC1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TANC1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG1_RAT	Dlg1	physical	15673434
DLG4_RAT	Dlg4	physical	15673434
HOME1_RAT	Homer1	physical	15673434
SPTN1_RAT	Sptan1	physical	15673434
DLGP1_RAT	Dlgap1	physical	15673434
KCC2A_RAT	Camk2a	physical	15673434
NMDE2_RAT	Grin2b	physical	15673434
GRIA1_RAT	Gria1	physical	15673434
AINX_RAT	Ina	physical	15673434

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.