AINX_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AINX_RAT
• UniProt AC: P23565
• Protein Name: Alpha-internexin
• Gene Name: Ina
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 505
• Protein Description: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity)..
• Protein Sequence: MSFGSEHYLCSASSYRKVFGDGSRLSARLSGPGASGSFRSQSLSRSNVASTAACSSASSLGLGLAYRRLPASDGLDLSQAAARTNEYKIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRELRAQLEEASSARAQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVAVAKPDLTSALREIRAQYESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQILELEERHSAEVAGYQDSIGQLESDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTSGLSISGLNPLPNPSYLLPPRILSSTTSKVSSAGLSLKKEEEEEEEEEEGASKEVTKKTSKVGESFEETLEETVVSTKKTEKSTIEEITTSSSQKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Acetylation	CSASSYRKVFGDGSR ECHHHHCHHHCCCCC	33.41	22902405
66	Phosphorylation	SLGLGLAYRRLPASD HCCCCHHHCCCCCCC	10.99	-
72	Phosphorylation	AYRRLPASDGLDLSQ HHCCCCCCCCCCHHH	30.21	-
78	Phosphorylation	ASDGLDLSQAAARTN CCCCCCHHHHHHHCC	19.89	-
87	Phosphorylation	AAARTNEYKIIRTNE HHHHCCCCEEEECCH	15.01	-
88	Acetylation	AARTNEYKIIRTNEK HHHCCCCEEEECCHH	26.02	22902405
95	Acetylation	KIIRTNEKEQLQGLN EEEECCHHHHHCCCH	53.48	22902405
95	Ubiquitination	KIIRTNEKEQLQGLN EEEECCHHHHHCCCH	53.48	-
216	Acetylation	ARLDLEKKVESLLDE HHHCHHHHHHHHHHH	41.69	22902405
219	Phosphorylation	DLEKKVESLLDELAF CHHHHHHHHHHHHHH	36.90	-
278	Ubiquitination	QYESLAAKNLQSAEE HHHHHHHHHCCCHHH	53.21	-
288	Acetylation	QSAEEWYKSKFANLN CCHHHHHHHHHCCHH	48.52	22902405
290	Acetylation	AEEWYKSKFANLNEQ HHHHHHHHHCCHHHH	44.32	22902405
315	Phosphorylation	SREEIHEYRRQLQAR HHHHHHHHHHHHHHH	9.27	-
335	Phosphorylation	GLRGANESLERQILE CCCCCCHHHHHHHHH	35.02	25403869
354	Phosphorylation	HSAEVAGYQDSIGQL HHHHHHCCHHHHHHH	10.22	-
369	Acetylation	ESDLRNTKSEMARHL HHHHHHCHHHHHHHH	48.22	22902405
379	Phosphorylation	MARHLREYQDLLNVK HHHHHHHHHHHHCHH	10.82	-
396	Phosphorylation	LDIEIAAYRKLLEGE HHHHHHHHHHHHCCC	10.16	-
398	Acetylation	IEIAAYRKLLEGEET HHHHHHHHHHCCCCC	44.76	72622467
408	Phosphorylation	EGEETRFSTSGLSIS CCCCCEECCCCCCCC	20.55	22673903
409	Phosphorylation	GEETRFSTSGLSISG CCCCEECCCCCCCCC	24.89	22673903
410	Phosphorylation	EETRFSTSGLSISGL CCCEECCCCCCCCCC	36.22	22673903
413	Phosphorylation	RFSTSGLSISGLNPL EECCCCCCCCCCCCC	20.45	22673903
415	Phosphorylation	STSGLSISGLNPLPN CCCCCCCCCCCCCCC	33.57	22673903
425	Phosphorylation	NPLPNPSYLLPPRIL CCCCCHHHCCCCHHC	17.32	-
434	Phosphorylation	LPPRILSSTTSKVSS CCCHHCCCCCCCCHH	32.05	28432305
435	Phosphorylation	PPRILSSTTSKVSSA CCHHCCCCCCCCHHC	31.54	28432305
436	Phosphorylation	PRILSSTTSKVSSAG CHHCCCCCCCCHHCC	28.62	28432305
437	Phosphorylation	RILSSTTSKVSSAGL HHCCCCCCCCHHCCC	31.02	28432305
440	Phosphorylation	SSTTSKVSSAGLSLK CCCCCCCHHCCCCCC	20.43	28432305
441	Phosphorylation	STTSKVSSAGLSLKK CCCCCCHHCCCCCCH	29.37	28432305
445	Phosphorylation	KVSSAGLSLKKEEEE CCHHCCCCCCHHHHH	36.91	28432305
468	Phosphorylation	SKEVTKKTSKVGESF CHHHHHHHHHCCCHH	35.02	28432305
469	Phosphorylation	KEVTKKTSKVGESFE HHHHHHHHHCCCHHH	33.93	28432305
474	Phosphorylation	KTSKVGESFEETLEE HHHHCCCHHHHHHHH	31.84	27097102
478	Phosphorylation	VGESFEETLEETVVS CCCHHHHHHHHHHHC	32.07	27097102
501	Phosphorylation	IEEITTSSSQKM--- HHHHHCCCCCCC---	34.39	28551015
502	Phosphorylation	EEITTSSSQKM---- HHHHCCCCCCC----	33.32	28551015

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AINX_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AINX_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AINX_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of AINX_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.