DLGP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DLGP1_RAT
• UniProt AC: P97836
• Protein Name: Disks large-associated protein 1 {ECO:0000305}
• Gene Name: Dlgap1 {ECO:0000312|RGD:620223}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 992
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse.
• Protein Description: Part of the postsynaptic scaffold in neuronal cells..
• Protein Sequence: MKGLSGSRSHHHGITCESACDSLSHHSDHKPYLLSPVDHHPADHPYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDESALVPRTLATKANRLPTNLLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGASKGGVNGGKASPDGSQTVRYGKRSKSKERRSEPKARSNASNASPTSPSWWSSDDNLDGDMCLYHTPSGVMTMGRCPDRSVSQYFMGAYNTISEQAVKASRSNNDVKCSTCANLPVTLDAPLLKKSAWSSTLTVSRAREVYQKASVNMDQAVVKSEACQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTGVIKLSSAVEVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDMISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGSNAAAVTTTTTIATVTTEDRKKDFKKNRCLSIGIQVDDAEESEKMAESKTSSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCKQMEREERENNLPEDILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPEAQTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	STFPRRHYTSQQELK CCCCCCCCCCHHHHC	13.28	-
77	Phosphorylation	FPRRHYTSQQELKDE CCCCCCCCHHHHCCC	23.77	21829588
118	Phosphorylation	LPLSRDGYHTLQYKR CCCCCCCCCCEEEEE	8.91	21829588
120	Phosphorylation	LSRDGYHTLQYKRTA CCCCCCCCEEEEEEE	13.68	-
123	Phosphorylation	DGYHTLQYKRTAVEH CCCCCEEEEEEEECC	12.92	-
169	Phosphorylation	GVNGGKASPDGSQTV CCCCCCCCCCCCCCC	27.32	30411139
300	Ubiquitination	RAREVYQKASVNMDQ HHHHHHHHHCCCHHH	25.58	-
311	Ubiquitination	NMDQAVVKSEACQQE CHHHHHHHCHHHHCH	35.66	-
323	Phosphorylation	QQERSCQYLQVPQDE HCHHCCCCCCCCHHH	11.93	-
350	Phosphorylation	IPCRRMRSGSYIKAM CCCHHHCCCCCEEEC	23.81	22673903
352	Phosphorylation	CRRMRSGSYIKAMGD CHHHCCCCCEEECCC	25.57	16452087
353	Phosphorylation	RRMRSGSYIKAMGDE HHHCCCCCEEECCCC	15.23	22673903
362	Phosphorylation	KAMGDEDSGDSDTSP EECCCCCCCCCCCCC	42.31	25403869
365	Phosphorylation	GDEDSGDSDTSPKPS CCCCCCCCCCCCCCC	46.44	25403869
367	Phosphorylation	EDSGDSDTSPKPSPK CCCCCCCCCCCCCHH	51.37	28551015
368	Phosphorylation	DSGDSDTSPKPSPKV CCCCCCCCCCCCHHH	35.60	28551015
372	Phosphorylation	SDTSPKPSPKVAARR CCCCCCCCHHHHHHH	43.40	28551015
381	Phosphorylation	KVAARRESYLKATQP HHHHHHHHHHHHCCC	33.67	22673903
389	Phosphorylation	YLKATQPSLTELTTL HHHHCCCCCHHCEEE	37.80	22108457
403	Phosphorylation	LKISNEHSPKLQIRS EEECCCCCCCCEEEC	19.97	27115346
405	Ubiquitination	ISNEHSPKLQIRSHS ECCCCCCCCEEECCH	56.91	-
412	Phosphorylation	KLQIRSHSYLRAVSE CCEEECCHHHHHHEE	27.40	30411139
413	Phosphorylation	LQIRSHSYLRAVSEV CEEECCHHHHHHEEE	8.52	28551015
418	Phosphorylation	HSYLRAVSEVSINRS CHHHHHHEEEEECCC	31.15	25403869
421	Phosphorylation	LRAVSEVSINRSLDS HHHHEEEEECCCCCC	15.30	25403869
425	Phosphorylation	SEVSINRSLDSLDPA EEEEECCCCCCCCCC	31.85	27097102
428	Phosphorylation	SINRSLDSLDPAGLL EECCCCCCCCCCCCC	39.71	25403869
436	Phosphorylation	LDPAGLLTSPKFRSR CCCCCCCCCHHHHCC	48.29	27097102
437	Phosphorylation	DPAGLLTSPKFRSRN CCCCCCCCHHHHCCC	26.51	27097102
446	Phosphorylation	KFRSRNESYMRAMST HHHCCCHHHHHHHHH	27.98	25403869
447	Phosphorylation	FRSRNESYMRAMSTI HHCCCHHHHHHHHHH	5.62	25403869
499	Phosphorylation	CFRMRSHSYVRAIEK CEECCCHHHHHHHHC	26.94	25403869
500	Phosphorylation	FRMRSHSYVRAIEKG EECCCHHHHHHHHCC	6.63	25403869
506	Ubiquitination	SYVRAIEKGCSQDDE HHHHHHHCCCCCCCC	60.13	-
509	Phosphorylation	RAIEKGCSQDDECVS HHHHCCCCCCCCCEE	45.36	30240740
516	Phosphorylation	SQDDECVSLRSSSPP CCCCCCEECCCCCCC	29.71	-
519	Phosphorylation	DECVSLRSSSPPRTT CCCEECCCCCCCCCC	40.22	-
521	Phosphorylation	CVSLRSSSPPRTTTT CEECCCCCCCCCCCE	39.92	-
525	O-linked_Glycosylation	RSSSPPRTTTTVRTI CCCCCCCCCCEEEEE	33.98	15578373
525	Phosphorylation	RSSSPPRTTTTVRTI CCCCCCCCCCEEEEE	33.98	-
526	O-linked_Glycosylation	SSSPPRTTTTVRTIQ CCCCCCCCCEEEEEE	23.04	15578367
526	Phosphorylation	SSSPPRTTTTVRTIQ CCCCCCCCCEEEEEE	23.04	-
557	Phosphorylation	CITTYKKTPPPVPPR CEEECCCCCCCCCCC	36.55	25403869
572	Phosphorylation	TTTKPFISITAQSST CCCCCEEEEEECCCC	17.79	22673903
574	Phosphorylation	TKPFISITAQSSTES CCCEEEEEECCCCHH	16.32	22673903
577	Phosphorylation	FISITAQSSTESAQD EEEEEECCCCHHHHH	36.44	22673903
578	Phosphorylation	ISITAQSSTESAQDA EEEEECCCCHHHHHH	24.90	22673903
579	Phosphorylation	SITAQSSTESAQDAY EEEECCCCHHHHHHH	38.92	22673903
581	Phosphorylation	TAQSSTESAQDAYMD EECCCCHHHHHHHHC	31.17	22673903
598	Phosphorylation	GQRGDMISQSGLSNS CCCCCCCCCCCCCCC	16.20	27097102
600	Phosphorylation	RGDMISQSGLSNSTE CCCCCCCCCCCCCCC	34.61	27097102
603	Phosphorylation	MISQSGLSNSTESLD CCCCCCCCCCCCCHH	32.06	27097102
605	Phosphorylation	SQSGLSNSTESLDSM CCCCCCCCCCCHHHH	30.12	27097102
606	Phosphorylation	QSGLSNSTESLDSMK CCCCCCCCCCHHHHH	33.57	27097102
608	Phosphorylation	GLSNSTESLDSMKAL CCCCCCCCHHHHHHH	37.25	27097102
611	Phosphorylation	NSTESLDSMKALTAA CCCCCHHHHHHHHHH	27.72	27097102
691	Phosphorylation	KTSSKFQSVGVQVEE CCCCCHHHCCCEECC	24.79	22817900
813	Ubiquitination	RDGHWFLKLLQAERD CCCCHHHHHHHHHHH	37.36	-
915	Ubiquitination	QLKANNWKQMDPLDK HHHHCCCCCCCCCCH	37.56	-
937	Ubiquitination	PVPKKPAKGPAPLIR CCCCCCCCCCCCCCC	74.15	-
947	Phosphorylation	APLIRERSLESSQRQ CCCCCHHCCCHHHHH	31.56	25403869
950	Phosphorylation	IRERSLESSQRQEAR CCHHCCCHHHHHHHH	36.74	25403869
973	Phosphorylation	AASVRQNSATESAES HHHHHHCCCCCCCHH	28.38	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
77	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
389	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
389	S	Phosphorylation	Kinase	CAMK2B	P08413	PSP
691	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
691	S	Phosphorylation	Kinase	CAMK2B	P08413	PSP
947	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
947	S	Phosphorylation	Kinase	CAMK2B	P08413	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DLGP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DLGP1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SHAN2_HUMAN	SHANK2	physical	10433268
SHAN1_RAT	Shank1	physical	10433268
SHAN3_RAT	Shank3	physical	10433268
DLG4_HUMAN	DLG4	physical	10433268

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.