SHAN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHAN1_RAT
• UniProt AC: Q9WV48
• Protein Name: SH3 and multiple ankyrin repeat domains protein 1
• Gene Name: Shank1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2167
• Subcellular Localization: Cytoplasm . Cell junction, synapse . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Colocalizes with alpha-latrotoxin receptor 1.
• Protein Description: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function..
• Protein Sequence: MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPQGTRGRGSGAPGNLASTRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGLKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCELLLYNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKETCARILLYRGANKDVKNNNGQTPFQVAVIAGNFELGELIRNHREQDVVPFQESPKYAARRRGPPGAGLTVPPALLRANSDTSMALPDWMVFSAPGASSSGTPGPTSGPQGQSQPSAPSTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSGTPRDGPAGGTGGSGGPGGSLGSRGRRRKLYSAVPGRSFMAVKSYQAQGEGEISLSKGEKIKVLSIGEGGFWEGQVKGRVGWFPSDCLEEVANRSQEGRQESRSDKAKRLFRHYTVGSYDSFDAPSLIDGIDSGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAWRAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVVMVTRHPDMDEAVHKKASQQAKRLPPPAISLRSKSMTSELEEMVSPWKKKIEYEQQPAAVPSMEKKRTVYQMALNKLDEILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRSQPSYDRPSFLPPGPGLMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTPPAPSSSGRLTPSPRGGPFNPSSGGPLPASSPSSFDGPSPPDTRGGGREKSLYHSAALPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTSGAPSPSHHSSSGGSSGPTQAPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQKGSIPSASSPTSPALPRSEPPPAGPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPDGAGGGGSSPSPAPATSPVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDEDGGDSGLGPGGPPGPRLRHSKSIDEGMFSAEPYLRLESGGSSGGYGAYAAGSRAYGGSGSSSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGTPQPPPRPPSPRYDAPPPTLHHHSPHSPHSPHARHEPVLRLWGDPARRELGYRAGLGSQEKALTASPPAARRSLLHRLPPTAPGVGPLLLQLGPEPPTPHPGVSKAWRTAAPEEPERLPLHVRFLENCQARPPPAGTRGSSTEDGPGVPPPSPRRVLPTSPTSPRGNEENGLPLLVLPPPAPSVDVDDGEFLFAEPLPPPLEFSNSFEKPESPLTPGPPHPLPDPPSPATPLPAAPPPAVAAAPPTLDSTASSLTSYDSEVATLTQGAPAAPGDPPAPGPPAPAAPAPPAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLSAEGGGNTGGVAGGGAGVASGTELLDTYVAYLDGQAFGGSGTPGPPYPPQLMTPSKLRGRALGTSGNLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALSACPGPSTAGVAGGPVAVEPEVPPVPLPAASSLPRKLLPWEEGPGPPPPPLPGPLSQPQASALATVKASIISELSSKLQQFGGSSTAGGALPWARGGSGGSTDSHHGGASYIPERTSSLQRQRLSEDSQTSLLSKPSSSIFQNWPKPPLPPLPTGSGVSSSTAAAPGATSPSASSASASTRHLQGVEFEMRPPLLRRAPSPSLLPASDHKVSPAPRPSSLPILPSGPIYPGLFDIRSSPTGGAGGSTDPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKPLGFWTKFDVADWLEWLGLSEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHRMNIDRALKFFLER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTHSPATSE ------CCCCCCCCH	42.22	25403869
4	Phosphorylation	----MTHSPATSEDE ----CCCCCCCCHHH	24.54	25403869
43	Methylation	GPQGTRGRGSGAPGN CCCCCCCCCCCCCCC	32.58	-
61	Phosphorylation	TRGLQGRSMSVPDDA CCCCCCCCCCCCCHH	23.41	18388127
63	Phosphorylation	GLQGRSMSVPDDAHF CCCCCCCCCCCHHHH	31.57	18388127
169	Ubiquitination	KQTNLDEKQLAKLHT ECCCCCHHHHHHHHH	50.72	-
178	Phosphorylation	LAKLHTKTGLKKFLE HHHHHHHHHHHHHHH	49.23	25403869
186	Phosphorylation	GLKKFLEYVQLGTSD HHHHHHHHHHHCCHH	8.81	16641100
191	Phosphorylation	LEYVQLGTSDKVARL HHHHHHCCHHHHHHH	42.20	16641100
192	Phosphorylation	EYVQLGTSDKVARLL HHHHHCCHHHHHHHH	33.37	16641100
253	Ubiquitination	DGMTALHKAACARHC CCCHHHHHHHHHHHH	38.23	-
302	Phosphorylation	RCCELLLYNRAQLGI HHHHHHEECHHHHCC	11.54	-
413	Phosphorylation	DVVPFQESPKYAARR CCCCCCCCHHHHHHH	18.86	30240740
518	Phosphorylation	RQPRGRPSSSGTPRD CCCCCCCCCCCCCCC	35.46	25403869
519	Phosphorylation	QPRGRPSSSGTPRDG CCCCCCCCCCCCCCC	35.15	25403869
520	Phosphorylation	PRGRPSSSGTPRDGP CCCCCCCCCCCCCCC	51.53	25403869
522	Phosphorylation	GRPSSSGTPRDGPAG CCCCCCCCCCCCCCC	19.66	25403869
534	Phosphorylation	PAGGTGGSGGPGGSL CCCCCCCCCCCCCCC	41.75	26022182
540	Phosphorylation	GSGGPGGSLGSRGRR CCCCCCCCCCCHHCH	35.16	25403869
543	Phosphorylation	GPGGSLGSRGRRRKL CCCCCCCCHHCHHHC	36.53	26022182
544	Methylation	PGGSLGSRGRRRKLY CCCCCCCHHCHHHCE	40.62	-
551	Phosphorylation	RGRRRKLYSAVPGRS HHCHHHCEECCCCCC	9.53	25403869
552	Phosphorylation	GRRRKLYSAVPGRSF HCHHHCEECCCCCCE	32.97	25403869
558	Phosphorylation	YSAVPGRSFMAVKSY EECCCCCCEEEEEEE	25.86	25403869
634	Phosphorylation	AKRLFRHYTVGSYDS HHHHHHHHCCCCCCC	10.00	22673903
635	Phosphorylation	KRLFRHYTVGSYDSF HHHHHHHCCCCCCCC	16.56	22673903
635 (in isoform 3)	Phosphorylation	-	16.56	22673903
638	Phosphorylation	FRHYTVGSYDSFDAP HHHHCCCCCCCCCCC	22.79	22673903
638 (in isoform 3)	Phosphorylation	-	22.79	22673903
639 (in isoform 3)	Phosphorylation	-	15.07	22673903
639	Phosphorylation	RHYTVGSYDSFDAPS HHHCCCCCCCCCCCH	15.07	22673903
641 (in isoform 3)	Phosphorylation	-	19.45	22673903
641	Phosphorylation	YTVGSYDSFDAPSLI HCCCCCCCCCCCHHC	19.45	22817900
671	Phosphorylation	VLLQKKDSEGFGFVL EEEEECCCCCCCEEE	48.80	-
783	Phosphorylation	RLPPPAISLRSKSMT HCCCCCEECCCCHHH	21.60	25403869
791	Phosphorylation	LRSKSMTSELEEMVS CCCCHHHHHHHHHHC	31.38	-
861	Ubiquitination	SLGKHRPKGFFATES HCCCCCCCCCEECCC	69.20	-
866	Phosphorylation	RPKGFFATESSFDPH CCCCCEECCCCCCCC	31.10	28432305
868	Phosphorylation	KGFFATESSFDPHHR CCCEECCCCCCCCCC	31.76	28432305
869	Phosphorylation	GFFATESSFDPHHRS CCEECCCCCCCCCCC	27.69	28432305
876	Phosphorylation	SFDPHHRSQPSYDRP CCCCCCCCCCCCCCC	41.93	25403869
879	Phosphorylation	PHHRSQPSYDRPSFL CCCCCCCCCCCCCCC	31.84	25403869
880	Phosphorylation	HHRSQPSYDRPSFLP CCCCCCCCCCCCCCC	23.74	25403869
884	Phosphorylation	QPSYDRPSFLPPGPG CCCCCCCCCCCCCCC	40.07	25403869
898	Phosphorylation	GLMLRQKSIGAAEDD CCEECCCCCCCCCCC	20.23	25403869
908	Phosphorylation	AAEDDRPYLAPPAMK CCCCCCCCCCCCCCC	19.18	-
954	Phosphorylation	PSSSGRLTPSPRGGP CCCCCCCCCCCCCCC	21.99	26022182
958	Methylation	GRLTPSPRGGPFNPS CCCCCCCCCCCCCCC	68.02	-
1054	Phosphorylation	LALGPQPSLRGWRGG CCCCCCCCCCCCCCC	26.00	25403869
1059	Methylation	QPSLRGWRGGGPSPT CCCCCCCCCCCCCCC	36.38	-
1064	Phosphorylation	GWRGGGPSPTSGAPS CCCCCCCCCCCCCCC	44.05	28432305
1066	Phosphorylation	RGGGPSPTSGAPSPS CCCCCCCCCCCCCCC	44.10	28432305
1067	Phosphorylation	GGGPSPTSGAPSPSH CCCCCCCCCCCCCCC	36.02	28432305
1071	Phosphorylation	SPTSGAPSPSHHSSS CCCCCCCCCCCCCCC	38.20	28432305
1073	Phosphorylation	TSGAPSPSHHSSSGG CCCCCCCCCCCCCCC	37.86	28432305
1076	Phosphorylation	APSPSHHSSSGGSSG CCCCCCCCCCCCCCC	22.30	28432305
1077	Phosphorylation	PSPSHHSSSGGSSGP CCCCCCCCCCCCCCC	28.75	28432305
1098	Methylation	RYFQLPPRAASAAMY HHCCCCHHHCCCCEE	40.63	-
1105	Phosphorylation	RAASAAMYVPARSGR HHCCCCEEEECCCCC	9.88	-
1109	Methylation	AAMYVPARSGRGRKG CCEEEECCCCCCCCC	33.31	-
1132	Phosphorylation	EGEPQKGSIPSASSP CCCCCCCCCCCCCCC	38.06	22673903
1135	Phosphorylation	PQKGSIPSASSPTSP CCCCCCCCCCCCCCC	38.83	22673903
1137	Phosphorylation	KGSIPSASSPTSPAL CCCCCCCCCCCCCCC	40.98	28432305
1138	Phosphorylation	GSIPSASSPTSPALP CCCCCCCCCCCCCCC	31.73	28432305
1140	Phosphorylation	IPSASSPTSPALPRS CCCCCCCCCCCCCCC	49.65	28432305
1141	Phosphorylation	PSASSPTSPALPRSE CCCCCCCCCCCCCCC	16.15	28432305
1257	Asymmetric dimethylarginine	WQNEARRRSTLFLST CCCHHHHCCEEEEEC	28.56	-
1257	Methylation	WQNEARRRSTLFLST CCCHHHHCCEEEEEC	28.56	-
1289	Phosphorylation	PGPRLRHSKSIDEGM CCCCCCCCCCCCCCC	22.97	25403869
1291	Phosphorylation	PRLRHSKSIDEGMFS CCCCCCCCCCCCCCC	37.98	25403869
1314	Phosphorylation	SGGSSGGYGAYAAGS CCCCCCCCCCCCCCC	11.34	-
1386	Phosphorylation	QPPPRPPSPRYDAPP CCCCCCCCCCCCCCC	25.37	28432305
1429	Methylation	ARRELGYRAGLGSQE HHHHHHHCCCCCCHH	22.00	-
1434	Phosphorylation	GYRAGLGSQEKALTA HHCCCCCCHHHHHHC	39.96	25403869
1440	Phosphorylation	GSQEKALTASPPAAR CCHHHHHHCCCHHHH	29.92	22817900
1442	Phosphorylation	QEKALTASPPAARRS HHHHHHCCCHHHHHH	26.61	22817900
1504	S-nitrosocysteine	HVRFLENCQARPPPA CHHHHHHCCCCCCCC	2.15	-
1504	S-nitrosylation	HVRFLENCQARPPPA CHHHHHHCCCCCCCC	2.15	16418269
1516	Phosphorylation	PPAGTRGSSTEDGPG CCCCCCCCCCCCCCC	30.69	28432305
1517	Phosphorylation	PAGTRGSSTEDGPGV CCCCCCCCCCCCCCC	38.34	28432305
1518	Phosphorylation	AGTRGSSTEDGPGVP CCCCCCCCCCCCCCC	39.53	28432305
1528	Phosphorylation	GPGVPPPSPRRVLPT CCCCCCCCCCCCCCC	36.49	28432305
1535	Phosphorylation	SPRRVLPTSPTSPRG CCCCCCCCCCCCCCC	43.08	28432305
1536	Phosphorylation	PRRVLPTSPTSPRGN CCCCCCCCCCCCCCC	25.00	25403869
1538	Phosphorylation	RVLPTSPTSPRGNEE CCCCCCCCCCCCCCC	51.64	28432305
1539	Phosphorylation	VLPTSPTSPRGNEEN CCCCCCCCCCCCCCC	18.91	25403869
1901	Methylation	GGALPWARGGSGGST CCCCCCCCCCCCCCC	46.25	-
1907	Phosphorylation	ARGGSGGSTDSHHGG CCCCCCCCCCCCCCC	32.35	25403869
1908	Phosphorylation	RGGSGGSTDSHHGGA CCCCCCCCCCCCCCC	44.81	25403869
2018	Phosphorylation	PASDHKVSPAPRPSS CCCCCCCCCCCCCCC	21.83	22673903
2022	Methylation	HKVSPAPRPSSLPIL CCCCCCCCCCCCCCC	45.93	-
2024	Phosphorylation	VSPAPRPSSLPILPS CCCCCCCCCCCCCCC	45.87	22673903
2025	Phosphorylation	SPAPRPSSLPILPSG CCCCCCCCCCCCCCC	40.63	22673903
2042	Methylation	YPGLFDIRSSPTGGA CCCCEEECCCCCCCC	32.69	-
2080	Methylation	GALSGASRSLSPTRL HHHCCCCCCCCCCCH	40.87	-
2083	Phosphorylation	SGASRSLSPTRLLSL CCCCCCCCCCCHHCC	26.02	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
783	S	Phosphorylation	Kinase	CAMK2A	P11275	PSP
783	S	Phosphorylation	Kinase	CAMK2B	P08413	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHAN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHAN1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOME1_RAT	Homer1	physical	10433269
DLG4_HUMAN	DLG4	physical	10433268
DLGP1_RAT	Dlgap1	physical	10433268

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.