HOME1_RAT - dbPTM
HOME1_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOME1_RAT
UniProt AC Q9Z214
Protein Name Homer protein homolog 1 {ECO:0000305}
Gene Name Homer1 {ECO:0000312|RGD:628725}
Organism Rattus norvegicus (Rat).
Sequence Length 366
Subcellular Localization Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse . Cell projection, dendritic spine . Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum..
Protein Description Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 3 counteracts the effects by competing for binding sites. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, and isoform 2 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines. [PubMed: 19345194]
Protein Sequence MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPAQNALPFSHSAGDRTQGLSHASSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHSHKTELSQTVQELEETLKVKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSELEQRLEKSQSEQDAFRSNLKTLLEILDGKIFELTELRDNLAKLLECS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MGEQPIFST
------CCCCCCEEC
42.10-
62PhosphorylationAIINSTITPNMTFTK
EEECCCCCCCCEEEE
14.5425403869
98AcetylationSSEHHLSKFAEKFQE
CCHHHHHHHHHHHHH
55.7622902405
102AcetylationHLSKFAEKFQEFKEA
HHHHHHHHHHHHHHH
49.2522902405
208UbiquitinationTLKGNNAKLTAALLE
HHHCCCHHHHHHHHH
48.79-
221UbiquitinationLESTANVKQWKQQLA
HHHHHCHHHHHHHHH
50.69-
302AcetylationQRDSLTQKLQEVEIR
HHHHHHHHHHHHHHH
47.0722902405
311UbiquitinationQEVEIRNKDLEGQLS
HHHHHHCCCHHHHHH
54.57-
318PhosphorylationKDLEGQLSELEQRLE
CCHHHHHHHHHHHHH
32.04-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOME1_RAT !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOME1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOME1_RAT !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHAN1_RATShank1physical
10433269
SHAN3_RATShank3physical
10433269
GRM5_MOUSEGrm5physical
9808458
GRM1_RATGrm1physical
9808458
HOME3_HUMANHOMER3physical
9808458

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOME1_RAT

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Related Literatures of Post-Translational Modification

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