GRM5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRM5_MOUSE
• UniProt AC: Q3UVX5
• Protein Name: Metabotropic glutamate receptor 5
• Gene Name: Grm5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1203
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity (By similarity)..
• Protein Sequence: MVLLLILSVLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFAQENSKYNKTCNSSLTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLDSLMKTNFTGVSGDMILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKSSSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMGNGGRATMSSSNGKSVTWAQNEKSTRGQHLWQRLSVHINKKENPNQTAVIKPFPKSTESRGQGAGAGGGSGPGAAGAGSAGCTATGGPEPPDAGPKALYDVAEAEERFPAAARPRSPSPISTLSHLAGSAGRTDDDAPSLHSETAARSSSSQGSLMEQISSVVTRFTANITELNSMMLSTAAAPGPPGTPICSSYLIPKEIQLPTTMTTFAEIQPLPAIEVTGGAQPATGPSPAQETPAGAEAAPGKPDLEELVALTPPSPFRDSVDSGSTTPNSPVSESALCIPSSPKYDTLIIRDYTQSSSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	N-linked_Glycosylation	SDPTLLPNITLGCEI CCCCCCCCCEECCEE	39.59	-
209	N-linked_Glycosylation	VDIVKRYNWTYVSAV HHHHHHCCCEEEEEE	28.75	-
218	Phosphorylation	TYVSAVHTEGNYGES EEEEEEEECCCCCHH	38.70	29895711
222	Phosphorylation	AVHTEGNYGESGMEA EEEECCCCCHHHHHH	32.88	29895711
225	Phosphorylation	TEGNYGESGMEAFKD ECCCCCHHHHHHHHC	38.79	29895711
258	Ubiquitination	AGEQSFDKLLKKLRS CCHHHHHHHHHHHHH	54.42	-
339	Phosphorylation	DVKWFDDYYLKLRPE CCCCCCCEEEEECCC	16.73	26160508
340	Phosphorylation	VKWFDDYYLKLRPET CCCCCCEEEEECCCC	12.35	26160508
377	N-linked_Glycosylation	AQENSKYNKTCNSSL HHCCHHCCCCCCCCC	36.58	-
381	N-linked_Glycosylation	SKYNKTCNSSLTLRT HHCCCCCCCCCEEEE	39.61	-
382	Phosphorylation	KYNKTCNSSLTLRTH HCCCCCCCCCEEEEE	28.95	29899451
385	Phosphorylation	KTCNSSLTLRTHHVQ CCCCCCCEEEEECCC	19.01	29899451
388	Phosphorylation	NSSLTLRTHHVQDSK CCCCEEEEECCCCCC	21.32	29899451
394	Phosphorylation	RTHHVQDSKMGFVIN EEECCCCCCHHHHHH	13.88	-
444	N-linked_Glycosylation	LDSLMKTNFTGVSGD HHHHHHCCCCCCCCC	27.28	-
733	N-linked_Glycosylation	REVYLICNTTNLGVV CEEEEEECCCCCCCC	42.83	-
827	Ubiquitination	KVYIILAKPERNVRS EEEEEEECCCCCHHH	43.92	-
837	Phosphorylation	RNVRSAFTTSTVVRM CCHHHCCEECEEEEE	21.39	22324799
838	Phosphorylation	NVRSAFTTSTVVRMH CHHHCCEECEEEEEE	18.88	22324799
839	Phosphorylation	VRSAFTTSTVVRMHV HHHCCEECEEEEEEE	19.02	25521595
840	Phosphorylation	RSAFTTSTVVRMHVG HHCCEECEEEEEEEC	22.41	22324799
856	Phosphorylation	GKSSSAASRSSSLVN CCCCCCHHHCHHHHH	32.20	29899451
858	Phosphorylation	SSSAASRSSSLVNLW CCCCHHHCHHHHHHH	23.06	29899451
859	Phosphorylation	SSAASRSSSLVNLWK CCCHHHCHHHHHHHH	26.95	21183079
860	Phosphorylation	SAASRSSSLVNLWKR CCHHHCHHHHHHHHH	37.27	25521595
868	Dimethylation	LVNLWKRRGSSGETL HHHHHHHCCCCCCHH	45.69	-
868	Methylation	LVNLWKRRGSSGETL HHHHHHHCCCCCCHH	45.69	24129315
870	Phosphorylation	NLWKRRGSSGETLRY HHHHHCCCCCCHHHH	33.10	25521595
871	Phosphorylation	LWKRRGSSGETLRYK HHHHCCCCCCHHHHH	43.39	22324799
874	Phosphorylation	RRGSSGETLRYKDRR HCCCCCCHHHHHHHH	21.77	22324799
876	Dimethylation	GSSGETLRYKDRRLA CCCCCHHHHHHHHHH	43.82	-
876	Methylation	GSSGETLRYKDRRLA CCCCCHHHHHHHHHH	43.82	54540785
887	Phosphorylation	RRLAQHKSEIECFTP HHHHHCCCEEEEECC	41.50	29899451
893	Phosphorylation	KSEIECFTPKGSMGN CCEEEEECCCCCCCC	35.43	29899451
921	Ubiquitination	VTWAQNEKSTRGQHL CEEEECCCCCCHHHH	65.75	-
924	Methylation	AQNEKSTRGQHLWQR EECCCCCCHHHHHHH	50.28	24129315
933	Phosphorylation	QHLWQRLSVHINKKE HHHHHHHHEEECCCC	17.53	25521595
945	Phosphorylation	KKENPNQTAVIKPFP CCCCCCCCEEEECCC	29.54	30635358
1014	Phosphorylation	PAAARPRSPSPISTL CCCCCCCCCCCHHHH	32.20	25177544
1016	Phosphorylation	AARPRSPSPISTLSH CCCCCCCCCHHHHHH	35.79	25521595
1019	Phosphorylation	PRSPSPISTLSHLAG CCCCCCHHHHHHHHC	27.04	29899451
1020	Phosphorylation	RSPSPISTLSHLAGS CCCCCHHHHHHHHCC	32.76	20415495
1022	Phosphorylation	PSPISTLSHLAGSAG CCCHHHHHHHHCCCC	19.28	29899451
1027	Phosphorylation	TLSHLAGSAGRTDDD HHHHHHCCCCCCCCC	23.18	20415495
1037	Phosphorylation	RTDDDAPSLHSETAA CCCCCCCCCCCHHHH	40.20	25521595
1040	Phosphorylation	DDAPSLHSETAARSS CCCCCCCCHHHHHCC	41.77	22817900
1042	Phosphorylation	APSLHSETAARSSSS CCCCCCHHHHHCCCC	28.73	25521595
1046	Phosphorylation	HSETAARSSSSQGSL CCHHHHHCCCCCCCH	29.82	21082442
1047	Phosphorylation	SETAARSSSSQGSLM CHHHHHCCCCCCCHH	28.58	29899451
1048	Phosphorylation	ETAARSSSSQGSLME HHHHHCCCCCCCHHH	28.11	19060867
1049	Phosphorylation	TAARSSSSQGSLMEQ HHHHCCCCCCCHHHH	40.27	22817900
1052	Phosphorylation	RSSSSQGSLMEQISS HCCCCCCCHHHHHHH	19.53	19060867
1058	O-linked_Glycosylation	GSLMEQISSVVTRFT CCHHHHHHHHHHHHH	19.44	55412679
1158	Phosphorylation	LVALTPPSPFRDSVD HHCCCCCCCCCCCCC	37.56	22561452
1168	Phosphorylation	RDSVDSGSTTPNSPV CCCCCCCCCCCCCCC	32.81	21183079
1170	Phosphorylation	SVDSGSTTPNSPVSE CCCCCCCCCCCCCCC	23.36	20415495
1173	Phosphorylation	SGSTTPNSPVSESAL CCCCCCCCCCCCCCE	28.07	25521595
1176	Phosphorylation	TTPNSPVSESALCIP CCCCCCCCCCCEECC	29.26	29899451
1178	Phosphorylation	PNSPVSESALCIPSS CCCCCCCCCEECCCC	21.02	29899451
1184	Phosphorylation	ESALCIPSSPKYDTL CCCEECCCCCCCCEE	39.08	19060867
1185	Phosphorylation	SALCIPSSPKYDTLI CCEECCCCCCCCEEE	21.76	25521595
1188	Phosphorylation	CIPSSPKYDTLIIRD ECCCCCCCCEEEEEE	19.97	29899451
1202	Phosphorylation	DYTQSSSSL------ ECCCCCCCC------	39.79	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
870	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
1158	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
1158	S	Phosphorylation	Kinase	ERK2	P28482	PSP
1158	S	Phosphorylation	Kinase	ERK1	Q63844	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRM5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRM5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.