SPTN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTN1_RAT
• UniProt AC: P16086
• Protein Name: Spectrin alpha chain, non-erythrocytic 1
• Gene Name: Sptan1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2472
• Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex . Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
• Protein Description: Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane..
• Protein Sequence: MDPSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQVASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDLAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAERHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGHYASDEVREKLSILSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLSRRNALHERAMHRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEATELKGVKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPMDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQGQIDNQTRITKEAGSVSLRMKQVEELYQSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLDILDQERTDLEKAWVQRRMMLDHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAVDHYAKGDIANRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSESHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHIQSKAIEARHASLMKRWTQLLANSATRKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEYMAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDGKGRELPTAFDYVEFTRSLFVN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDPSGVKV -------CCCCCCCC		-
30	Acetylation	LDRYHRFKELSTLRR HHHHHHHHHHHHHHH		22902405
33	Phosphorylation	YHRFKELSTLRRQKL HHHHHHHHHHHHHHH		25403869
34	Phosphorylation	HRFKELSTLRRQKLE HHHHHHHHHHHHHHH		25403869
39	Acetylation	LSTLRRQKLEDSYRF HHHHHHHHHHHHHHH		22902405
58	Acetylation	RDAEELEKWIQEKLQ CCHHHHHHHHHHHHH		22902405
73	Acetylation	VASDENYKDPTNLQG HCCCCCCCCCCCHHH		22902405
73	Ubiquitination	VASDENYKDPTNLQG HCCCCCCCCCCCHHH		-
150	Acetylation	IKLLQAQKLVQYLRE HHHHHHHHHHHHHHH		22902405
150	Ubiquitination	IKLLQAQKLVQYLRE HHHHHHHHHHHHHHH		-
190	Acetylation	HVEVLQKKFEEFQTD HHHHHHHHHHHHHHH		22902405
214	Acetylation	EVNQFAAKLIQEQHP HHHHHHHHHHHHHCC		22902405
227	Acetylation	HPEEELIKTKQEEVN CCHHHHHHHHHHHHH		22902405
274	Succinylation	TIGWIKEKEQLMASD HHHHHHHHHHHHCCC		26843850
289	Phosphorylation	DFGRDLASVQALLRK CCCHHHHHHHHHHHH		22673903
310	Acetylation	DLAALEDKVKALCAE HHHHHHHHHHHHHHH		22902405
328	Phosphorylation	LQQSHPLSANQIQVK HHHHCCCCHHHHHHC		25403869
416	Phosphorylation	EIDAHEDSFKSADES CCCCCCHHHCCCCHH		25575281
419	Phosphorylation	AHEDSFKSADESGQA CCCHHHCCCCHHHHH		25575281
423	Phosphorylation	SFKSADESGQALLAA HHCCCCHHHHHHHHH		25575281
441	Acetylation	ASDEVREKLSILSEE CCHHHHHHHHHCCHH		22902405
441	Ubiquitination	ASDEVREKLSILSEE CCHHHHHHHHHCCHH		-
507	Acetylation	DSVEALLKKHEDFEK HHHHHHHHHHHHHHH		22902405
514	Acetylation	KKHEDFEKSLSAQEE HHHHHHHHHCHHHHH		22902405
586	Acetylation	FRDSDELKSWVNEKM HCCHHHHHHHHHHHH		22902405
587	Phosphorylation	RDSDELKSWVNEKMK CCHHHHHHHHHHHHH		-
592	Acetylation	LKSWVNEKMKTATDE HHHHHHHHHHHHCHH		22902405
602	Succinylation	TATDEAYKDPSNLQG HHCHHHHCCCCCCCH		26843850
613	Acetylation	NLQGKVQKHQAFEAE CCCHHHHHHHHHHHH		22902405
633	Acetylation	SRIDALEKAGQKLID HHHHHHHHHCHHHHC		22902405
633	Ubiquitination	SRIDALEKAGQKLID HHHHHHHHHCHHHHC		-
637	Acetylation	ALEKAGQKLIDVNHY HHHHHCHHHHCCCHH		22902405
646	Acetylation	IDVNHYAKEEVAARM HCCCHHCHHHHHHHH		22902405
658	Phosphorylation	ARMNEVISLWKKLLE HHHHHHHHHHHHHHH		22673903
661	Acetylation	NEVISLWKKLLEATE HHHHHHHHHHHHHHH		22902405
670	Acetylation	LLEATELKGVKLREA HHHHHHCCCCCHHHH		22902405
673	Acetylation	ATELKGVKLREANQQ HHHCCCCCHHHHHHH		22902405
718	Acetylation	TNVQNLQKKHALLEA CCHHHHHHHHHHHHH		22902405
756	Acetylation	HFDAENIKKKQEALV CCCHHHHHHHHHHHH		22902405
770	Acetylation	VARYEALKEPMVARK HHHHHHHHCCHHHHH		22902405
777	Acetylation	KEPMVARKQKLADSL HCCHHHHHHHHHHHH		22902405
779	Acetylation	PMVARKQKLADSLRL CHHHHHHHHHHHHHH		22902405
783	Phosphorylation	RKQKLADSLRLQQLF HHHHHHHHHHHHHHH		30181290
803	Acetylation	EETWIREKEPIAAST CCHHHHCCCCCCCCC		-
803	Succinylation	EETWIREKEPIAAST CCHHHHCCCCCCCCC		26843850
814	Ubiquitination	AASTNRGKDLIGVQN CCCCCCCCHHHHHHH		-
824	Acetylation	IGVQNLLKKHQALQA HHHHHHHHHHHHHHH		22902405
862	Acetylation	HFAAEDVKAKLSELN CCCHHHHHHHHHHHH		22902405
871	Acetylation	KLSELNQKWEALKAK HHHHHHHHHHHHHHH		22902405
909	Ubiquitination	AESWMREKEPIVGST HHHHHHHCCCCCCCC		-
920	Acetylation	VGSTDYGKDEDSAEA CCCCCCCCCHHHHHH		22902405
920	Succinylation	VGSTDYGKDEDSAEA CCCCCCCCCHHHHHH		26843850
924	Phosphorylation	DYGKDEDSAEALLKK CCCCCHHHHHHHHHH		22673903
967	Phosphorylation	VAPMDDETGKELVLA CCCCCCCCCHHHHHH		25575281
976	Phosphorylation	KELVLALYDYQEKSP HHHHHHHHCCCCCCC		25575281
978	Phosphorylation	LVLALYDYQEKSPRE HHHHHHCCCCCCCCC		22108457
981	Ubiquitination	ALYDYQEKSPREVTM HHHCCCCCCCCCCCC		-
982	Phosphorylation	LYDYQEKSPREVTMK HHCCCCCCCCCCCCC		30240740
990	Ubiquitination	PREVTMKKGDILTLL CCCCCCCCCCEEEHH		-
999	Phosphorylation	DILTLLNSTNKDWWK CEEEHHCCCCCCEEE		-
1002	Acetylation	TLLNSTNKDWWKVEV EHHCCCCCCEEEEEE		8264379
1029	Phosphorylation	KKLDPAQSASRENLL EECCHHHCCCHHHHH		23984901
1031	Phosphorylation	LDPAQSASRENLLEE CCHHHCCCHHHHHHH		23984901
1041	Phosphorylation	NLLEEQGSIALRQGQ HHHHHHCCHHHHCCC		23800682
1057	Ubiquitination	DNQTRITKEAGSVSL CCCCCEEEHHCCCCC		-
1061	Phosphorylation	RITKEAGSVSLRMKQ CEEEHHCCCCCCHHH		30181290
1063	Phosphorylation	TKEAGSVSLRMKQVE EEHHCCCCCCHHHHH		30181290
1075	Phosphorylation	QVEELYQSLLELGEK HHHHHHHHHHHHHHH		28432305
1082	Acetylation	SLLELGEKRKGMLEK HHHHHHHHHHHHHHH		165157
1093	Acetylation	MLEKSCKKFMLFREA HHHHHHHHHHHHHHH		22902405
1132	Acetylation	QVEVLQKKFDDFQKD HHHHHHHHHHHHHHH		22902405
1141	Acetylation	DDFQKDLKANESRLK HHHHHHHHHCHHHHH		22902405
1176	Phosphorylation	AVQQQEVYGMMPRDE HHHHHHHHCCCCCCC		27097102
1186	Phosphorylation	MPRDEADSKTASPWK CCCCCCCCCCCCCHH		28432305
1188	Phosphorylation	RDEADSKTASPWKSA CCCCCCCCCCCHHHH		28432305
1190	Phosphorylation	EADSKTASPWKSARL CCCCCCCCCHHHHHH		22108457
1207	Phosphorylation	HTVATFNSIKELNER HHHHHHHHHHHHHHH		-
1217	Phosphorylation	ELNERWRSLQQLAEE HHHHHHHHHHHHHHH		23712012
1226	Phosphorylation	QQLAEERSQLLGSAH HHHHHHHHHHHHCHH		23984901
1231	Phosphorylation	ERSQLLGSAHEVQRF HHHHHHHCHHHHHHH		23984901
1246	Acetylation	HRDADETKEWIEEKN HCCHHHHHHHHHHHH		22902405
1274	Succinylation	SVQALQRKHEGFERD HHHHHHHHCCCHHHH		26843850
1291	Phosphorylation	ALGDKVNSLGETAQR HHHHHHHHHHHHHHH		28689409
1295	Phosphorylation	KVNSLGETAQRLIQS HHHHHHHHHHHHHHH		25575281
1302	Phosphorylation	TAQRLIQSHPESAED HHHHHHHHCCCCHHH		28432305
1306	Phosphorylation	LIQSHPESAEDLKEK HHHHCCCCHHHHHHH		28432305
1311	Acetylation	PESAEDLKEKCTELN CCCHHHHHHHHHHHH		22902405
1315	Phosphorylation	EDLKEKCTELNQAWT HHHHHHHHHHHHHHH		28689409
1322	Phosphorylation	TELNQAWTSLGKRAD HHHHHHHHHHHHHHH		27097102
1323	Phosphorylation	ELNQAWTSLGKRADQ HHHHHHHHHHHHHHH		27097102
1327	Methylation	AWTSLGKRADQRKAK HHHHHHHHHHHHHHC		26494221
1334	Acetylation	RADQRKAKLGDSHDL HHHHHHHCCCCHHHH		22902405
1338	Phosphorylation	RKAKLGDSHDLQRFL HHHCCCCHHHHHHHH		22108457
1363	Phosphorylation	NGIRGLVSSDELAKD HHHHCCCCCHHHHHC		28432305
1364	Phosphorylation	GIRGLVSSDELAKDV HHHCCCCCHHHHHCC		28432305
1369	Acetylation	VSSDELAKDVTGAEA CCCHHHHHCCCCHHH		22902405
1411	Phosphorylation	QLLAHGHYASPEIKE HHHHCCCCCCHHHHH		28689409
1413	Phosphorylation	LAHGHYASPEIKEKL HHCCCCCCHHHHHHH		28689409
1417	Acetylation	HYASPEIKEKLDILD CCCCHHHHHHHHHHH		8264403
1419	Acetylation	ASPEIKEKLDILDQE CCHHHHHHHHHHHHH		22902405
1419	Ubiquitination	ASPEIKEKLDILDQE CCHHHHHHHHHHHHH		-
1473	Acetylation	AFLNTEDKGDSLDSV HHHCCCCCCCCCHHH		22902405
1476	Phosphorylation	NTEDKGDSLDSVEAL CCCCCCCCCHHHHHH		28689409
1479	Phosphorylation	DKGDSLDSVEALIKK CCCCCCHHHHHHHHH		28689409
1485	Acetylation	DSVEALIKKHEDFDK HHHHHHHHHCCCHHH		22902405
1492	Acetylation	KKHEDFDKAINVQEE HHCCCHHHHHCCCHH		22902405
1519	Acetylation	IAVDHYAKGDIANRR HHHHHHCCCCHHHHH		22902405
1545	Phosphorylation	AQMIEKRSKLGESQT HHHHHHHHHHCCCHH		25575281
1550	Phosphorylation	KRSKLGESQTLQQFS HHHHHCCCHHHHHHH		29779826
1552	Phosphorylation	SKLGESQTLQQFSRD HHHCCCHHHHHHHCC		22108457
1557	Phosphorylation	SQTLQQFSRDVDEIE CHHHHHHHCCHHHHH		27097102
1573	Phosphorylation	WISEKLQTASDESYK HHHHHHHCCCCCCCC		25575281
1575	Phosphorylation	SEKLQTASDESYKDP HHHHHCCCCCCCCCC		25575281
1578	Phosphorylation	LQTASDESYKDPTNI HHCCCCCCCCCCCCC		25575281
1579	Phosphorylation	QTASDESYKDPTNIQ HCCCCCCCCCCCCCC		25575281
1591	Acetylation	NIQSKHQKHQAFEAE CCCHHHHHHHHHHHH		22902405
1615	Phosphorylation	GVIDMGNSLIERGAC HHEECCCCHHHCCCC		28432305
1630	Acetylation	AGSEDAVKARLAALA CCCHHHHHHHHHHHH		8264415
1647	Phosphorylation	WQFLVQKSAEKSQKL HHHHHHHHHHHHHHH		-
1665	Phosphorylation	NKQQNFNTGIKDFDF HHHCCCCCCCCCHHH		18779572
1698	Acetylation	ASVNNLLKKHQLLEA HHHHHHHHHHHHHHC		22902405
1708	Phosphorylation	QLLEADISAHEDRLK HHHHCHHHHCHHHHH		30181290
1715	Acetylation	SAHEDRLKDLNSQAD HHCHHHHHHHHHHHH		22902405
1781	Acetylation	DDEESWIKEKKLLVS CCHHHHHHHHEEEEC		22902405
1783	Acetylation	EESWIKEKKLLVSSE HHHHHHHHEEEECCC		22902405
1828	Acetylation	QGVLDTGKKLSDDNT HHHHHCCCCCCCCCC		22902405
1853	Acetylation	AQFVEHWKELKQLAA HHHHHHHHHHHHHHH		22902405
1856	Acetylation	VEHWKELKQLAAARG HHHHHHHHHHHHHHC		22902405
1910	Acetylation	AAIQGLLKKHEAFET HHHHHHHHHHCHHCC		134817
1911	Acetylation	AIQGLLKKHEAFETD HHHHHHHHHCHHCCC		22902405
1923	Acetylation	ETDFTVHKDRVNDVC CCCCEECHHHHHHHH		22902405
1938	Acetylation	TNGQDLIKKNNHHEE CCHHHHHHCCCCCCH		22902405
1963	Acetylation	GKVSDLEKAAAQRKA CCHHHHHHHHHHHHC		22902405
1971	Acetylation	AAAQRKAKLDENSAF HHHHHHCCCCCCCCC		22902405
2000	Acetylation	GEKENSLKTDDYGRD CCCCCCCCCCCCCCC		22902405
2020	Phosphorylation	TLLTKQETFDAGLQA HHHHHHHHHHHHHHH		27097102
2052	Acetylation	AAKHIQSKAIEARHA HHHHHHHHHHHHHHH		22902405
2052	Ubiquitination	AAKHIQSKAIEARHA HHHHHHHHHHHHHHH		-
2063	Acetylation	ARHASLMKRWTQLLA HHHHHHHHHHHHHHH		22902405
2066	Phosphorylation	ASLMKRWTQLLANSA HHHHHHHHHHHHCHH		-
2077	Acetylation	ANSATRKKKLLEAQS HCHHHHHHHHHHHHH		22902405
2078	Acetylation	NSATRKKKLLEAQSH CHHHHHHHHHHHHHH		22902405
2088	Acetylation	EAQSHFRKVEDLFLT HHHHHHHHHHHHHHH		22902405
2098	Acetylation	DLFLTFAKKASAFNS HHHHHHHHHHHHHHH		22902405
2138	Phosphorylation	EAHDAFRSSLSSAQA HHHHHHHHHHHHHCC		22673903
2139	Phosphorylation	AHDAFRSSLSSAQAD HHHHHHHHHHHHCCC		22673903
2141	Phosphorylation	DAFRSSLSSAQADFN HHHHHHHHHHCCCHH		22673903
2142	Phosphorylation	AFRSSLSSAQADFNQ HHHHHHHHHCCCHHH		22673903
2184	Acetylation	ETWRNLQKIIKEREL HHHHHHHHHHHHHHH		22902405
2187	Acetylation	RNLQKIIKERELELQ HHHHHHHHHHHHHHH		22902405
2195	Acetylation	ERELELQKEQRRQEE HHHHHHHHHHHHHHH		22902405
2205	Acetylation	RRQEENDKLRQEFAQ HHHHHHHHHHHHHHH		22902405
2264	Acetylation	AMRSQLKKIEDLGAA HHHHHHHHHHHHHHH		22902405
2326	Acetylation	GVTEEALKEFSMMFK CCCHHHHHHHHHHHH		22902405
2333	Acetylation	KEFSMMFKHFDKDKS HHHHHHHHCCCCCCC		22902405
2337	Acetylation	MMFKHFDKDKSGRLN HHHHCCCCCCCCCCC		22902405
2404	Acetylation	SRETENVKSSEEIES CCCCCCCCCHHHHHH		22902405
2421	Acetylation	RALSSEGKPYVTKEE HHHHCCCCCCCCHHH		22902405
2423	Phosphorylation	LSSEGKPYVTKEELY HHCCCCCCCCHHHHH		-
2426	Acetylation	EGKPYVTKEELYQNL CCCCCCCHHHHHHHC		22902405
2426	Ubiquitination	EGKPYVTKEELYQNL CCCCCCCHHHHHHHC		-
2430	Phosphorylation	YVTKEELYQNLTREQ CCCHHHHHHHCCHHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1176	Y	Phosphorylation	Kinase	LCK	P06239	PSP
1176	Y	Phosphorylation	Kinase	SRC	Q9WUD9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTN1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTN1_RAT	Actn1	physical	11274145
NMDE2_RAT	Grin2b	physical	9670010
NAC1_RAT	Slc8a1	physical	14593108
ITPR1_RAT	Itpr1	physical	14593108
SHAN3_RAT	Shank3	physical	23897824

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.