NAC1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NAC1_RAT
• UniProt AC: Q01728
• Protein Name: Sodium/calcium exchanger 1
• Gene Name: Slc8a1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 971
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite .
• Protein Description: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. [PubMed: 8422940]
• Protein Sequence: MLRLSLPPNVSMGFRLVTLVALLFTHVDHITADTEAETGGNETTECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNMDVVENDPVSKVFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSEVSEDGILDSNHVSAIACLGSPNTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKKALLLNELGGFTLTEGKKMYGQPVFRKVHARDHPIPSTVISISEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	N-linked_Glycosylation	TEAETGGNETTECTG CCCCCCCCCCEEECE	44.80	-
157	N-linked_Glycosylation	VIEVCGHNFTAGDLG HHHHCCCCCCCCCCC	22.65	-
282	Phosphorylation	HEGDRPASKTEIEMD ECCCCCCCCCEEEEC	42.67	30411139
283	Ubiquitination	EGDRPASKTEIEMDG CCCCCCCCCEEEECC	52.89	-
284	Phosphorylation	GDRPASKTEIEMDGK CCCCCCCCEEEECCE	39.43	28432305
333	Acetylation	ILKELKQKHPDKEIE HHHHHHHHCCCHHHH	56.36	22902405
337	Acetylation	LKQKHPDKEIEQLIE HHHHCCCHHHHHHHH	66.11	22902405
389	Phosphorylation	DQARKAVSMHEVNMD HHHHHCHHHHCCCCH	21.20	29779826
572	Ubiquitination	GNVIIPYKTIEGTAR CCEEEEEEEECCCCC	37.36	-
606	Ubiquitination	IVKTISVKVIDDEEY EEEEEEEEECCHHHH	27.04	-
634	Ubiquitination	RLVEMSEKKALLLNE EEEECHHHHCHHHHH	35.72	-
638 (in isoform 4)	Phosphorylation	-	6.04	28432305
639 (in isoform 2)	Phosphorylation	-	4.94	28432305
640 (in isoform 4)	Phosphorylation	-	42.28	28432305
641 (in isoform 2)	Phosphorylation	-	49.08	28432305
647 (in isoform 3)	Ubiquitination	-	3.71	-
653 (in isoform 3)	Ubiquitination	-	5.32	-
731	Phosphorylation	VDKLIKKTNLALVVG HHHHHHHCCEEEEEC	30.38	21289289

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
731	T	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NAC1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NAC1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT1A2_RAT	Atp1a2	physical	14593108
AT1A3_RAT	Atp1a3	physical	14593108
SPTN1_RAT	Sptan1	physical	14593108
AT2A2_RAT	Atp2a2	physical	14593108
ITPR1_RAT	Itpr1	physical	14593108

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.