ACTN1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACTN1_RAT
• UniProt AC: Q9Z1P2
• Protein Name: Alpha-actinin-1
• Gene Name: Actn1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 892
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm, myofibril, sarcomere, Z line . Cell membrane . Cell junction . Cell projection, ruffle . Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and c
• Protein Description: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)..
• Protein Sequence: MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDHYDSQQ -------CCCCCCCC	6.90	-
6	Phosphorylation	--MDHYDSQQTNDYM --CCCCCCCCCCCCC	19.61	-
12	Phosphorylation	DSQQTNDYMQPEEDW CCCCCCCCCCCHHHC	10.34	-
31	Acetylation	LLDPAWEKQQRKTFT CCCHHHHHHHHHHHH	40.82	-
50	Phosphorylation	SHLRKAGTQIENIEE HHHHHHCHHHHCHHH	31.10	52777
89	Acetylation	RGKMRVHKISNVNKA CCCCCEEECCCHHHH	45.00	72602455
95	Acetylation	HKISNVNKALDFIAS EECCCHHHHHHHHHH	46.15	-
102	Phosphorylation	KALDFIASKGVKLVS HHHHHHHHCCCEEEE	25.73	63847327
140	Phosphorylation	RFAIQDISVEETSAK HHHHHCCCCCCCCHH	31.59	6479445
195	Acetylation	PELIDYGKLRKDDPL HHHHCCCCCCCCCCC	38.60	22646637
195	Ubiquitination	PELIDYGKLRKDDPL HHHHCCCCCCCCCCC	38.60	-
246	Phosphorylation	MTYVSSFYHAFSGAQ HHHHHHHHHHHHCHH	8.32	30117
284	Phosphorylation	EDYEKLASDLLEWIR HHHHHHHHHHHHHHH	38.95	73403987
312	Acetylation	TMQAMQQKLEDFRDY HHHHHHHHHHHHHHH	36.63	-
331	Ubiquitination	KPPKVQEKCQLEINF CCCCHHHCEEEEEEC	15.36	-
331	Acetylation	KPPKVQEKCQLEINF CCCCHHHCEEEEEEC	15.36	1891875
340	Phosphorylation	QLEINFNTLQTKLRL EEEEECCHHHHHHHH	18.99	23984901
343	Phosphorylation	INFNTLQTKLRLSNR EECCHHHHHHHHHCC	34.85	23984901
376	Acetylation	GCLEQAEKGYEEWLL HHHHHHHHHHHHHHH	70.57	-
398	Acetylation	RLDHLAEKFRQKASI HHHHHHHHHHHHHHH	39.99	134711
402	Ubiquitination	LAEKFRQKASIHEAW HHHHHHHHHHHHHHC	39.58	-
404	Phosphorylation	EKFRQKASIHEAWTD HHHHHHHHHHHHCCC	31.36	5130919
410	Phosphorylation	ASIHEAWTDGKEAML HHHHHHCCCHHHHHH	41.75	30181290
420	Acetylation	KEAMLRQKDYETATL HHHHHHHCCHHHCHH	56.71	51083463
431	Acetylation	TATLSEIKALLKKHE HCHHHHHHHHHHHHH	29.00	-
442	Phosphorylation	KKHEAFESDLAAHQD HHHHHHHHHHHHCHH	31.32	73409871
471	Phosphorylation	LDYYDSPSVNARCQK CCCCCCCCHHHHHHH	31.77	-
563	Succinylation	ATLPDADKERLAILG HHCCCCCHHHHEEEE	46.59	26843850
563	Acetylation	ATLPDADKERLAILG HHCCCCCHHHHEEEE	46.59	72585307
676	Acetylation	SHLRQYEKSIVNYKP HHHHHHHHHHHCCCC	40.32	22646645
677	Phosphorylation	HLRQYEKSIVNYKPK HHHHHHHHHHCCCCC	21.59	-
682	Acetylation	EKSIVNYKPKIDQLE HHHHHCCCCCHHHCC	34.33	-
741	Ubiquitination	QILTRDAKGISQEQM HHHCCCCCCCCHHHH	62.15	-
887	Phosphorylation	MSFSTALYGESDL-- HCHHHHHHCCCCC--	19.18	22673903
890	Phosphorylation	STALYGESDL----- HHHHHCCCCC-----	39.59	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
12	Y	Phosphorylation	Kinase	FAK1	O35346	Uniprot
404	S	Phosphorylation	Kinase	PRKACA	P00517	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACTN1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACTN1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of ACTN1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.