ZNHI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNHI3_HUMAN
• UniProt AC: Q15649
• Protein Name: Zinc finger HIT domain-containing protein 3
• Gene Name: ZNHIT3
• Organism: Homo sapiens (Human).
• Sequence Length: 155
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Sequence: MASLKCSTVVCVICLEKPKYRCPACRVPYCSVVCFRKHKEQCNPETRPVEKKIRSALPTKTVKPVENKDDDDSIADFLNSDEEEDRVSLQNLKNLGESATLRSLLLNPHLRQLMVNLDQGEDKAKLMRAYMQEPLFVEFADCCLGIVEPSQNEES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
55	Phosphorylation	PVEKKIRSALPTKTV CCHHHHHHCCCCCCE	37.32	21406692
59	Phosphorylation	KIRSALPTKTVKPVE HHHHCCCCCCEECCC	39.95	21406692
60	Ubiquitination	IRSALPTKTVKPVEN HHHCCCCCCEECCCC	49.75	-
61	Phosphorylation	RSALPTKTVKPVENK HHCCCCCCEECCCCC	35.92	24732914
73	Phosphorylation	ENKDDDDSIADFLNS CCCCCCCCHHHHHCC	27.03	23927012
80	Phosphorylation	SIADFLNSDEEEDRV CHHHHHCCCCHHHHH	48.85	23927012
88	Phosphorylation	DEEEDRVSLQNLKNL CCHHHHHCHHHHHHH	25.73	23927012
88 (in isoform 2)	Phosphorylation	-	25.73	29507054
93	Ubiquitination	RVSLQNLKNLGESAT HHCHHHHHHHHHHHH	58.64	21890473
123	Ubiquitination	NLDQGEDKAKLMRAY HCCCCCHHHHHHHHH	43.02	21890473
125	Ubiquitination	DQGEDKAKLMRAYMQ CCCCHHHHHHHHHHC	48.86	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNHI3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNHI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNHI3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNF4A_HUMAN	HNF4A	physical	11916906
HECD1_HUMAN	HECTD1	physical	26186194
NUFP1_HUMAN	NUFIP1	physical	25170085
NUFP1_HUMAN	NUFIP1	physical	27594683
NH2L1_HUMAN	NHP2L1	physical	27594683
NUFP1_HUMAN	NUFIP1	physical	25404746
NUFP1_HUMAN	NUFIP1	physical	28561026
PRP19_HUMAN	PRPF19	physical	28561026
UBP11_HUMAN	USP11	physical	28561026
ZNHI3_HUMAN	ZNHIT3	physical	28561026

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.
PubMed: 18691976

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, AND MASSSPECTROMETRY.
PubMed: 17081983