dbPTM

NUFP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NUFP1_HUMAN
UniProt AC	Q9UHK0
Protein Name	Nuclear fragile X mental retardation-interacting protein 1
Gene Name	NUFIP1
Organism	Homo sapiens (Human).
Sequence Length	495
Subcellular Localization	Nucleus . Distributed in the nucleus in a dot-like pattern.
Protein Description	Binds RNA..
Protein Sequence	MAEPTSDFETPIGWHASPELTPTLGPLSDTAPPRDSWMFWAMLPPPPPPLTSSLPAAGSKPSSESQPPMEAQSLPGAPPPFDAQILPGAQPPFDAQSPLDSQPQPSGQPWNFHASTSWYWRQSSDRFPRHQKSFNPAVKNSYYPRKYDAKFTDFSLPPSRKQKKKKRKEPVFHFFCDTCDRGFKNQEKYDKHMSEHTKCPELDCSFTAHEKIVQFHWRNMHAPGMKKIKLDTPEEIARWREERRKNYPTLANIERKKKLKLEKEKRGAVLTTTQYGKMKGMSRHSQMAKIRSPGKNHKWKNDNSRQRAVTGSGSHLCDLKLEGPPEANADPLGVLINSDSESDKEEKPQHSVIPKEVTPALCSLMSSYGSLSGSESEPEETPIKTEADVLAENQVLDSSAPKSPSQDVKATVRNFSEAKSENRKKSFEKTNPKRKKDYHNYQTLFEPRTHHPYLLEMLLAPDIRHERNVILQCVRYIIKKDFFGLDTNSAKSKDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEPTSDFETPI ---CCCCCCCCCCCC	32.22	24043423
6	Phosphorylation	--MAEPTSDFETPIG --CCCCCCCCCCCCC	51.52	24043423
10	Phosphorylation	EPTSDFETPIGWHAS CCCCCCCCCCCCCCC	21.87	26074081
17	Phosphorylation	TPIGWHASPELTPTL CCCCCCCCCCCCCCC	13.15	26074081
21	Phosphorylation	WHASPELTPTLGPLS CCCCCCCCCCCCCCC	16.74	26074081
23	Phosphorylation	ASPELTPTLGPLSDT CCCCCCCCCCCCCCC	38.83	26074081
28	Phosphorylation	TPTLGPLSDTAPPRD CCCCCCCCCCCCCCC	35.73	24043423
30	Phosphorylation	TLGPLSDTAPPRDSW CCCCCCCCCCCCCCC	37.37	24043423
126	Methylation	YWRQSSDRFPRHQKS EEECCCCCCCCCHHH	45.47	115485749
133	Phosphorylation	RFPRHQKSFNPAVKN CCCCCHHHCCHHHHC	24.56	18187866
189	Phosphorylation	GFKNQEKYDKHMSEH CCCCHHHHHHHHHHH	29.48	30301811
194	Phosphorylation	EKYDKHMSEHTKCPE HHHHHHHHHHCCCCC	26.41	30301811
205	Phosphorylation	KCPELDCSFTAHEKI CCCCCCCCCCCCHHH	25.87	25159151
229	Sumoylation	APGMKKIKLDTPEEI CCCCCCCCCCCHHHH	49.54	-
229	Sumoylation	APGMKKIKLDTPEEI CCCCCCCCCCCHHHH	49.54	-
232	Phosphorylation	MKKIKLDTPEEIARW CCCCCCCCHHHHHHH	42.93	28674419
247	Phosphorylation	REERRKNYPTLANIE HHHHHHHCCCHHHHH	10.71	25159151
257	Acetylation	LANIERKKKLKLEKE HHHHHHHHHHCCHHH	70.34	69479
260	Acetylation	IERKKKLKLEKEKRG HHHHHHHCCHHHHHC	64.58	88931
265	Acetylation	KLKLEKEKRGAVLTT HHCCHHHHHCCEEEE	68.17	69483
265	Ubiquitination	KLKLEKEKRGAVLTT HHCCHHHHHCCEEEE	68.17	24816145
271	Phosphorylation	EKRGAVLTTTQYGKM HHHCCEEEEHHHHCC	22.62	20068231
277	Acetylation	LTTTQYGKMKGMSRH EEEHHHHCCCCCCCC	32.29	25953088
282	Phosphorylation	YGKMKGMSRHSQMAK HHCCCCCCCCCHHHC	35.19	22210691
292	Phosphorylation	SQMAKIRSPGKNHKW CHHHCCCCCCCCCCC	41.29	20068231
310	Phosphorylation	NSRQRAVTGSGSHLC CCCCEECCCCCCCCC	25.33	28555341
312	Phosphorylation	RQRAVTGSGSHLCDL CCEECCCCCCCCCCE	27.97	25159151
314	Phosphorylation	RAVTGSGSHLCDLKL EECCCCCCCCCCEEE	18.25	23312004
338	Phosphorylation	PLGVLINSDSESDKE CCCEEECCCCCCCCC	35.20	26055452
340	Phosphorylation	GVLINSDSESDKEEK CEEECCCCCCCCCCC	38.53	26055452
342	Phosphorylation	LINSDSESDKEEKPQ EECCCCCCCCCCCCC	58.91	26055452
351	Phosphorylation	KEEKPQHSVIPKEVT CCCCCCCCCCCHHHH	19.25	22115753
358	Phosphorylation	SVIPKEVTPALCSLM CCCCHHHHHHHHHHH	12.16	30177828
363	Phosphorylation	EVTPALCSLMSSYGS HHHHHHHHHHHHCCC	28.14	28102081
366	Phosphorylation	PALCSLMSSYGSLSG HHHHHHHHHCCCCCC	26.21	28102081
367	Phosphorylation	ALCSLMSSYGSLSGS HHHHHHHHCCCCCCC	21.39	28102081
368	Phosphorylation	LCSLMSSYGSLSGSE HHHHHHHCCCCCCCC	11.92	28102081
370	Phosphorylation	SLMSSYGSLSGSESE HHHHHCCCCCCCCCC	15.89	28102081
372	Phosphorylation	MSSYGSLSGSESEPE HHHCCCCCCCCCCCC	41.80	28102081
374	Phosphorylation	SYGSLSGSESEPEET HCCCCCCCCCCCCCC	34.28	28102081
376	Phosphorylation	GSLSGSESEPEETPI CCCCCCCCCCCCCCC	61.21	28102081
381	Phosphorylation	SESEPEETPIKTEAD CCCCCCCCCCCCHHH	28.75	28102081
385	Phosphorylation	PEETPIKTEADVLAE CCCCCCCCHHHHHHH	36.81	29396449
398	Phosphorylation	AENQVLDSSAPKSPS HHCCCCCCCCCCCCC	25.00	28450419
399	Phosphorylation	ENQVLDSSAPKSPSQ HCCCCCCCCCCCCCH	48.54	22115753
403	Phosphorylation	LDSSAPKSPSQDVKA CCCCCCCCCCHHHHH	28.82	30266825
405	Phosphorylation	SSAPKSPSQDVKATV CCCCCCCCHHHHHHH	46.21	30266825
411	Phosphorylation	PSQDVKATVRNFSEA CCHHHHHHHHHHHHH	17.80	26074081
416	Phosphorylation	KATVRNFSEAKSENR HHHHHHHHHHHHHHH	39.95	26074081
419	Ubiquitination	VRNFSEAKSENRKKS HHHHHHHHHHHHHHH	55.01	24816145
420	Phosphorylation	RNFSEAKSENRKKSF HHHHHHHHHHHHHHH	47.34	26074081
476	Phosphorylation	VILQCVRYIIKKDFF HHHHHHHHHHHHHHC	6.13	18669648
487	Phosphorylation	KDFFGLDTNSAKSKD HHHCCCCCCCCCCCC	35.79	18669648
489	Phosphorylation	FFGLDTNSAKSKDV- HCCCCCCCCCCCCC-	38.88	18669648

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NUFP1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NUFP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NUFP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCNT1_HUMAN	CCNT1	physical	15107825
CDK9_HUMAN	CDK9	physical	15107825
FMR1_HUMAN	FMR1	physical	12837692
FMR1_HUMAN	FMR1	physical	10556305
BRCA1_HUMAN	BRCA1	physical	15107825
KLF6_HUMAN	KLF6	physical	17636026
RUVB1_HUMAN	RUVBL1	physical	17636026
RUVB2_HUMAN	RUVBL2	physical	17636026
NCAM1_HUMAN	NCAM1	physical	26186194
DPYL1_HUMAN	CRMP1	physical	26186194
DPYL3_HUMAN	DPYSL3	physical	26186194
DPYL2_HUMAN	DPYSL2	physical	26186194
DPYL5_HUMAN	DPYSL5	physical	26186194
STXB1_HUMAN	STXBP1	physical	26186194
ATP4A_HUMAN	ATP4A	physical	26186194
RAB14_HUMAN	RAB14	physical	26186194
AT2B2_HUMAN	ATP2B2	physical	26186194
GPM6B_HUMAN	GPM6B	physical	26186194
H15_HUMAN	HIST1H1B	physical	26186194
DNM1L_HUMAN	DNM1L	physical	26186194
H2B1L_HUMAN	HIST1H2BL	physical	26186194
VPP1_HUMAN	ATP6V0A1	physical	26186194
CNTN1_HUMAN	CNTN1	physical	26186194
DCX_HUMAN	DCX	physical	26186194
DCLK1_HUMAN	DCLK1	physical	26186194
SCAM5_HUMAN	SCAMP5	physical	26186194
SYN1_HUMAN	SYN1	physical	26186194
TRIM2_HUMAN	TRIM2	physical	26186194
FA49B_HUMAN	FAM49B	physical	26186194
AP180_HUMAN	SNAP91	physical	26186194
SYT1_HUMAN	SYT1	physical	26186194
ZNHI3_HUMAN	ZNHIT3	physical	26186194
MTAP2_HUMAN	MAP2	physical	26186194
HPCL4_HUMAN	HPCAL4	physical	26186194
VISL1_HUMAN	VSNL1	physical	26186194
AMPH_HUMAN	AMPH	physical	26186194
BIN1_HUMAN	BIN1	physical	26186194
DYN3_HUMAN	DNM3	physical	26186194
DYN1_HUMAN	DNM1	physical	26186194
CAD13_HUMAN	CDH13	physical	26186194
E41L1_HUMAN	EPB41L1	physical	26186194
STX1A_HUMAN	STX1A	physical	26186194
STX1B_HUMAN	STX1B	physical	26186194
GNAZ_HUMAN	GNAZ	physical	26186194
GNA11_HUMAN	GNA11	physical	26186194
GNAQ_HUMAN	GNAQ	physical	26186194
GPDM_HUMAN	GPD2	physical	26186194
GNAO_HUMAN	GNAO1	physical	26186194
GBG2_HUMAN	GNG2	physical	26186194
GPM6A_HUMAN	GPM6A	physical	26186194
PDE2A_HUMAN	PDE2A	physical	26186194
ANK2_HUMAN	ANK2	physical	26186194
SYUB_HUMAN	SNCB	physical	26186194
SYUA_HUMAN	SNCA	physical	26186194
GRIA2_HUMAN	GRIA2	physical	26186194
RAB6B_HUMAN	RAB6B	physical	26186194
RAB3B_HUMAN	RAB3B	physical	26186194
RAB3A_HUMAN	RAB3A	physical	26186194
KCC2B_HUMAN	CAMK2B	physical	26186194
KCC2A_HUMAN	CAMK2A	physical	26186194
EF1A2_HUMAN	EEF1A2	physical	26186194
HPCA_HUMAN	HPCA	physical	26186194
NCALD_HUMAN	NCALD	physical	26186194
RAB5B_HUMAN	RAB5B	physical	26186194
MP3B2_HUMAN	MAP1LC3B2	physical	26186194
NDRG4_HUMAN	NDRG4	physical	26186194
S12A5_HUMAN	SLC12A5	physical	26186194
NTRI_HUMAN	NTM	physical	26186194
CADM2_HUMAN	CADM2	physical	26186194
SNAB_HUMAN	NAPB	physical	26186194
TAU_HUMAN	MAPT	physical	26186194
DPYL4_HUMAN	DPYSL4	physical	26186194
MP2K1_HUMAN	MAP2K1	physical	26186194
CAMKV_HUMAN	CAMKV	physical	26186194
HBD_HUMAN	HBD	physical	26186194
NCS1_HUMAN	NCS1	physical	26186194
PLXA2_HUMAN	PLXNA2	physical	26186194
CALB2_HUMAN	CALB2	physical	26186194
SRCN1_HUMAN	SRCIN1	physical	26186194
VAMP2_HUMAN	VAMP2	physical	26186194
H2AW_HUMAN	H2AFY2	physical	26186194
CBPE_HUMAN	CPE	physical	26186194
SYPH_HUMAN	SYP	physical	26186194
EDIL3_HUMAN	EDIL3	physical	26186194
ADDB_HUMAN	ADD2	physical	26186194
GLSK_HUMAN	GLS	physical	26186194
GSK3B_HUMAN	GSK3B	physical	26186194
L1CAM_HUMAN	L1CAM	physical	26186194
SNP25_HUMAN	SNAP25	physical	26186194
SFXN3_HUMAN	SFXN3	physical	26186194
ZNHI3_HUMAN	ZNHIT3	physical	25170085
ZNHI3_HUMAN	ZNHIT3	physical	27594683
ZNHI3_HUMAN	ZNHIT3	physical	28514442
HPCA_HUMAN	HPCA	physical	28514442
GRIA2_HUMAN	GRIA2	physical	28514442
SYN1_HUMAN	SYN1	physical	28514442
H2B1L_HUMAN	HIST1H2BL	physical	28514442
VISL1_HUMAN	VSNL1	physical	28514442
STX1B_HUMAN	STX1B	physical	28514442
DCLK1_HUMAN	DCLK1	physical	28514442
SNP25_HUMAN	SNAP25	physical	28514442
RUVB1_HUMAN	RUVBL1	physical	28514442
DPYL1_HUMAN	CRMP1	physical	28514442
KCC2A_HUMAN	CAMK2A	physical	28514442
MTAP2_HUMAN	MAP2	physical	28514442
STX1A_HUMAN	STX1A	physical	28514442
EDIL3_HUMAN	EDIL3	physical	28514442
GPM6B_HUMAN	GPM6B	physical	28514442
STXB1_HUMAN	STXBP1	physical	28514442
DPYL3_HUMAN	DPYSL3	physical	28514442
ATP4A_HUMAN	ATP4A	physical	28514442
TAU_HUMAN	MAPT	physical	28514442
CALB2_HUMAN	CALB2	physical	28514442
NDRG4_HUMAN	NDRG4	physical	28514442
HPCL4_HUMAN	HPCAL4	physical	28514442
DNM1L_HUMAN	DNM1L	physical	28514442
PDE2A_HUMAN	PDE2A	physical	28514442
SNAB_HUMAN	NAPB	physical	28514442
E41L1_HUMAN	EPB41L1	physical	28514442
RAB5B_HUMAN	RAB5B	physical	28514442
SYT1_HUMAN	SYT1	physical	28514442
AP180_HUMAN	SNAP91	physical	28514442
L1CAM_HUMAN	L1CAM	physical	28514442
S12A5_HUMAN	SLC12A5	physical	28514442
SYPH_HUMAN	SYP	physical	28514442
SRCN1_HUMAN	SRCIN1	physical	28514442
RAB3A_HUMAN	RAB3A	physical	28514442
H2AW_HUMAN	H2AFY2	physical	28514442
CNTN1_HUMAN	CNTN1	physical	28514442
SYUB_HUMAN	SNCB	physical	28514442
GPM6A_HUMAN	GPM6A	physical	28514442
DPYL2_HUMAN	DPYSL2	physical	28514442
H15_HUMAN	HIST1H1B	physical	28514442
DCX_HUMAN	DCX	physical	28514442
NTRI_HUMAN	NTM	physical	28514442
NCALD_HUMAN	NCALD	physical	28514442
NCAM1_HUMAN	NCAM1	physical	28514442
ANK2_HUMAN	ANK2	physical	28514442
CAMKV_HUMAN	CAMKV	physical	28514442
RAB6B_HUMAN	RAB6B	physical	28514442
DYN1_HUMAN	DNM1	physical	28514442
MP2K1_HUMAN	MAP2K1	physical	28514442
GNAO_HUMAN	GNAO1	physical	28514442
GBG2_HUMAN	GNG2	physical	28514442
MP3B2_HUMAN	MAP1LC3B2	physical	28514442
TRIM2_HUMAN	TRIM2	physical	28514442
AT2B2_HUMAN	ATP2B2	physical	28514442
MAP1A_HUMAN	MAP1A	physical	28514442
KCC2B_HUMAN	CAMK2B	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
GNAZ_HUMAN	GNAZ	physical	28514442
MARE3_HUMAN	MAPRE3	physical	28514442
RAB3B_HUMAN	RAB3B	physical	28514442
VATC1_HUMAN	ATP6V1C1	physical	28514442
DPYL5_HUMAN	DPYSL5	physical	28514442
GLSK_HUMAN	GLS	physical	28514442
CBPE_HUMAN	CPE	physical	28514442
GPDM_HUMAN	GPD2	physical	28514442
BIN1_HUMAN	BIN1	physical	28514442
FA49B_HUMAN	FAM49B	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
ADDB_HUMAN	ADD2	physical	28514442
CAD13_HUMAN	CDH13	physical	28514442
SFXN3_HUMAN	SFXN3	physical	28514442
GBG7_HUMAN	GNG7	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442
KAP3_HUMAN	PRKAR2B	physical	28514442
ZNHI3_HUMAN	ZNHIT3	physical	25404746
RUVB1_HUMAN	RUVBL1	physical	25404746
RUVB2_HUMAN	RUVBL2	physical	25404746
SMN_HUMAN	SMN1	physical	26275778
GEMI6_HUMAN	GEMIN6	physical	26275778
DDX20_HUMAN	DDX20	physical	26275778

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NUFP1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338; SER-340; SER-342;TYR-476; THR-487 AND SER-489, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-338; SER-340 ANDSER-342, AND MASS SPECTROMETRY.	17081983 [Abstract]