PDE2A_HUMAN - dbPTM
PDE2A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE2A_HUMAN
UniProt AC O00408
Protein Name cGMP-dependent 3',5'-cyclic phosphodiesterase
Gene Name PDE2A
Organism Homo sapiens (Human).
Sequence Length 941
Subcellular Localization Isoform PDE2A3: Cell membrane
Lipid-anchor .
Isoform PDE2A2: Mitochondrion matrix . Mitochondrion inner membrane . Mitochondrion outer membrane .
Isoform PDE2A1: Cytoplasm .
Isoform 5: Mitochondrion .
Protein Description Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Plays an important role in growth and invasion of malignant melanoma cells (e.g. pseudomyxoma peritonei (PMP) cell line). [PubMed: 24705027; Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration (By similarity Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L]
Protein Sequence MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGQACGHSI
------CCCCCCCCH		24.6420213681
2N-myristoyl glycine------MGQACGHSI
------CCCCCCCCH		24.64-
5S-palmitoylation---MGQACGHSILCR
---CCCCCCCCHHHC		3.7619632989
11S-palmitoylationACGHSILCRSQQYPA
CCCCCHHHCCCCCCC		3.6119632989
13PhosphorylationGHSILCRSQQYPAAR
CCCHHHCCCCCCCCC		22.19-
125PhosphorylationGCNGLGFSDLPGKPL
CCCCCCCCCCCCCCH		36.12-
213PhosphorylationVQNPPEGTAEDQKGG
HCCCCCCCCCCCCCC		25.80-
305PhosphorylationQVVEDKKSIQLKDLT
HHHCCCCCEECCCCC		22.7023286773
321PhosphorylationEDVQQLQSMLGCELQ
HHHHHHHHHHCCHHH		25.2723286773
337PhosphorylationMLCVPVISRATDQVV
HHHHHHHCCCHHHHH		18.9823286773
508UbiquitinationNILCFPIKNENQEVI
CEEEEECCCCCCCEE		59.45-
523UbiquitinationGVAELVNKINGPWFS
EHHHHHHHHCCCHHH		30.03-
573PhosphorylationLANEMMMYHMKVSDD
HHHHHHHHHCCCCHH		4.85-
582PhosphorylationMKVSDDEYTKLLHDG
CCCCHHHHHHHHCCC		19.03-
584UbiquitinationVSDDEYTKLLHDGIQ
CCHHHHHHHHCCCCC		48.42-
632PhosphorylationDMNFINNYKIDCPTL
HCCCCCCCCCCCHHH		12.5830624053
638PhosphorylationNYKIDCPTLARFCLM
CCCCCCHHHHHHHHH		39.1030624053
712UbiquitinationNSFQVASKSVLAALY
CHHHHHCHHHHHHHH		34.54-
754PhosphorylationDHFSRKDYQRMLDLM
CCCCHHHHHHHHHHH		10.8922817900
854PhosphorylationMMDREKAYIPELQIS
HHHHHHHHCCHHHHH		28.24-
871PhosphorylationEHIAMPIYKLLQDLF
HHCHHHHHHHHHHHC		6.96-
880UbiquitinationLLQDLFPKAAELYER
HHHHHCHHHHHHHHH		53.55-
901UbiquitinationHWTKVSHKFTIRGLP
CCEEEECCEEECCCC		36.37-
903PhosphorylationTKVSHKFTIRGLPSN
EEEECCEEECCCCCC		17.9924719451
909PhosphorylationFTIRGLPSNNSLDFL
EEECCCCCCCCCCCC		54.4019369195
912PhosphorylationRGLPSNNSLDFLDEE
CCCCCCCCCCCCCCC		33.3029802988
920PhosphorylationLDFLDEEYEVPDLDG
CCCCCCCCCCCCCCC		21.8527642862
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDE2A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE2A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE2A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PDE2A_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00227 Aminophylline (USP/INN); Somophyllin (TN); Theophylline ethylenediamine (TN)
D00371 Theophylline (JP16); Elixophyllin (TN); Quibron-t (TN); Theo-24 (TN); Theodur G (TN); Theolair (TN);
D00528 Anhydrous caffeine (JP16); Caffeine (USP); Anhydrous caffeine (TN)
D00718 Flavoxate hydrochloride (JP16/USAN); Urispas (TN)
D01220 Trapidil (JP16/INN); Rocornal (TN)
D01453 Caffeine hydrate (JP16); Caffeine monohydrate; Caffeine (TN)
D01630 Propentofylline (JAN/INN)
D01712 Theophylline sodium acetate (JAN)
D01771 Proxyphylline (JAN/INN); Monophyllin (TN)
D02017 Choline theophylline (JAN); Oxtriphylline (USP); Choline theophyllinate (INN); Theophyline - choline
D02218 Papaverine hydrochloride (JP16/USP); Pavabid (TN)
D05429 Aminophylline hydrate (JP16)
D06103 Theophylline (USP); Theophylline monohydrate; Accurbron (TN)
D06104 Theophylline sodium glycinate (USP); Asbron (TN)
D06132 Tibenelast sodium (USAN)
D07089 Moxaverine (INN)
D07425 Papaverine (BAN); Mesotina (TN)
D07439 Papaverine sulfate; Papaverine SAD (TN)
D07603 Caffeine citrate (USP); Cafcit (TN)
D07961 Flavoxate (INN); Bladuril (TN)
D08238 Moxaverine hydrochloride; Certonal (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDE2A_HUMAN

loading...

Related Literatures of Post-Translational Modification
Myristoylation
ReferencePubMed
"Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system.";
Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.;
Proteomics 10:1780-1793(2010).
Cited for: MYRISTOYLATION AT GLY-2.
"Dual acylation of PDE2A splice variant 3: targeting to synapticmembranes.";
Russwurm C., Zoidl G., Koesling D., Russwurm M.;
J. Biol. Chem. 284:25782-25790(2009).
Cited for: MYRISTOYLATION AT GLY-2, PALMITOYLATION AT CYS-5 AND CYS-11, ANDSUBCELLULAR LOCATION.
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-909, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory