NDRG4_HUMAN - dbPTM
NDRG4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NDRG4_HUMAN
UniProt AC Q9ULP0
Protein Name Protein NDRG4
Gene Name NDRG4
Organism Homo sapiens (Human).
Sequence Length 352
Subcellular Localization Cytoplasm, cytosol .
Protein Description Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner..
Protein Sequence MPECWDGEHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLSGLTSTLPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTVPNAKTLRCPVMLVVGDNAPAEDGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYIAYLKDRRLSGGAVPSASMTRLARSRTASLTSASSVDGSRPQACTHSESSEGLGQVNHTMEVSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20 (in isoform 6)Phosphorylation-3.74-
35PhosphorylationGNRPAILTYHDVGLN
CCCCEEEEEEECCCC		16.8227762562
36PhosphorylationNRPAILTYHDVGLNH
CCCEEEEEEECCCCC		7.8027762562
118PhosphorylationIGVGAGAYVLAKFAL
ECCCHHHHHHHHHHH		8.62-
205PhosphorylationLQLFWNMYNSRRDLD
HHHHHHCHHCCCCCC		13.5324043423
207PhosphorylationLFWNMYNSRRDLDIN
HHHHCHHCCCCCCCC		15.9424043423
253PhosphorylationCNSKLDPTTTTFLKM
CCCCCCCCCCHHHHH		36.1229083192
254PhosphorylationNSKLDPTTTTFLKMA
CCCCCCCCCHHHHHH		29.2729083192
255PhosphorylationSKLDPTTTTFLKMAD
CCCCCCCCHHHHHHH		20.3029083192
256PhosphorylationKLDPTTTTFLKMADS
CCCCCCCHHHHHHHC		25.5229083192
263PhosphorylationTFLKMADSGGLPQVT
HHHHHHHCCCCCCCC		25.8129083192
270PhosphorylationSGGLPQVTQPGKLTE
CCCCCCCCCCCHHHH		24.6529083192
281 (in isoform 2)Phosphorylation-11.7627174698
281PhosphorylationKLTEAFKYFLQGMGY
HHHHHHHHHHHHCCC		11.76-
288 (in isoform 2)Phosphorylation-3.5727174698
291 (in isoform 2)Phosphorylation-12.5327174698
293 (in isoform 2)Phosphorylation-36.1927174698
295 (in isoform 2)Phosphorylation-39.5927174698
298PhosphorylationYLKDRRLSGGAVPSA
EEECCCCCCCCCCCH		33.1128857561
299 (in isoform 5)Phosphorylation-32.4427174698
299 (in isoform 8)Phosphorylation-32.4427174698
300 (in isoform 2)Phosphorylation-21.7427174698
306 (in isoform 8)Phosphorylation-25.6427174698
306 (in isoform 5)Phosphorylation-25.6427174698
309 (in isoform 8)Phosphorylation-20.0827174698
309 (in isoform 5)Phosphorylation-20.0827174698
311 (in isoform 7)Phosphorylation-12.2427174698
311 (in isoform 5)Phosphorylation-12.2427174698
311 (in isoform 8)Phosphorylation-12.2427174698
313 (in isoform 5)Phosphorylation-28.5127174698
313PhosphorylationSMTRLARSRTASLTS
HHHHHHHHCCCCCCC		28.5124501219
313 (in isoform 8)Phosphorylation-28.5127174698
313 (in isoform 3)Phosphorylation-28.5127174698
315PhosphorylationTRLARSRTASLTSAS
HHHHHHCCCCCCCCC		23.1129978859
317PhosphorylationLARSRTASLTSASSV
HHHHCCCCCCCCCCC		31.4119664994
318 (in isoform 5)Phosphorylation-3.9927174698
318 (in isoform 7)Phosphorylation-3.9927174698
318 (in isoform 8)Phosphorylation-3.9927174698
319PhosphorylationRSRTASLTSASSVDG
HHCCCCCCCCCCCCC		21.5429978859
320 (in isoform 3)Phosphorylation-31.2927174698
320PhosphorylationSRTASLTSASSVDGS
HCCCCCCCCCCCCCC		31.2928348404
321 (in isoform 7)Phosphorylation-10.6927174698
322PhosphorylationTASLTSASSVDGSRP
CCCCCCCCCCCCCCC		30.5727251275
323PhosphorylationASLTSASSVDGSRPQ
CCCCCCCCCCCCCCC		24.7628348404
323 (in isoform 3)Phosphorylation-24.7627174698
323 (in isoform 7)Phosphorylation-24.7627174698
325 (in isoform 3)Phosphorylation-51.8327174698
325 (in isoform 7)Phosphorylation-51.8327174698
327PhosphorylationSASSVDGSRPQACTH
CCCCCCCCCCCCCCC		36.0028348404
327 (in isoform 3)Phosphorylation-36.0027174698
330 (in isoform 7)Phosphorylation-48.2127174698
332 (in isoform 3)Phosphorylation-2.7227174698
333PhosphorylationGSRPQACTHSESSEG
CCCCCCCCCCCCCCC		31.3028348404
333 (in isoform 6)Phosphorylation-31.3027174698
335PhosphorylationRPQACTHSESSEGLG
CCCCCCCCCCCCCCC		22.4828348404
337PhosphorylationQACTHSESSEGLGQV
CCCCCCCCCCCCCCC		36.3828348404
338PhosphorylationACTHSESSEGLGQVN
CCCCCCCCCCCCCCC		31.4728348404
340 (in isoform 6)Phosphorylation-36.7427174698
343 (in isoform 6)Phosphorylation-37.5727174698
345 (in isoform 6)Phosphorylation-19.6127174698
347 (in isoform 6)Phosphorylation-15.1527174698
352 (in isoform 6)Phosphorylation-8.5827174698
376 (in isoform 6)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NDRG4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NDRG4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NDRG4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CKLF5_HUMANCMTM5physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NDRG4_HUMAN

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Related Literatures of Post-Translational Modification

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