| UniProt ID | CADM2_HUMAN | |
|---|---|---|
| UniProt AC | Q8N3J6 | |
| Protein Name | Cell adhesion molecule 2 | |
| Gene Name | CADM2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 435 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Cell junction, synapse . Cell projection, axon . Found in the axoplasm of myelinated axons. |
|
| Protein Description | Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.. | |
| Protein Sequence | MIWKRSAVLRFYSVCGLLLQGSQGQFPLTQNVTVVEGGTAILTCRVDQNDNTSLQWSNPAQQTLYFDDKKALRDNRIELVRASWHELSISVSDVSLSDEGQYTCSLFTMPVKTSKAYLTVLGVPEKPQISGFSSPVMEGDLMQLTCKTSGSKPAADIRWFKNDKEIKDVKYLKEEDANRKTFTVSSTLDFRVDRSDDGVAVICRVDHESLNATPQVAMQVLEIHYTPSVKIIPSTPFPQEGQPLILTCESKGKPLPEPVLWTKDGGELPDPDRMVVSGRELNILFLNKTDNGTYRCEATNTIGQSSAEYVLIVHDVPNTLLPTTIIPSLTTATVTTTVAITTSPTTSATTSSIRDPNALAGQNGPDHALIGGIVAVVVFVTLCSIFLLGRYLARHKGTYLTNEAKGAEDAPDADTAIINAEGSQVNAEEKKEYFI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MIWKRSAVLRFYS --CCCCHHHHHHHHH | 20.99 | 23532336 | |
| 31 | N-linked_Glycosylation | GQFPLTQNVTVVEGG CCCCCCCEEEEEECC | 26.62 | UniProtKB CARBOHYD | |
| 51 | N-linked_Glycosylation | CRVDQNDNTSLQWSN EEECCCCCCCEEECC | 38.83 | UniProtKB CARBOHYD | |
| 161 | Ubiquitination | AADIRWFKNDKEIKD CCEEEEECCCCCCCC | 58.22 | - | |
| 181 | Phosphorylation | EEDANRKTFTVSSTL HHHCCCCEEEEEEEE | 22.69 | 29209046 | |
| 183 | Phosphorylation | DANRKTFTVSSTLDF HCCCCEEEEEEEEEE | 25.39 | 29209046 | |
| 185 | Phosphorylation | NRKTFTVSSTLDFRV CCCEEEEEEEEEEEE | 17.97 | 29209046 | |
| 186 | Phosphorylation | RKTFTVSSTLDFRVD CCEEEEEEEEEEEEE | 28.75 | 29209046 | |
| 187 | Phosphorylation | KTFTVSSTLDFRVDR CEEEEEEEEEEEEEC | 23.88 | 29209046 | |
| 209 | Phosphorylation | ICRVDHESLNATPQV EEEECHHHCCCCHHH | 24.41 | 24719451 | |
| 291 | N-linked_Glycosylation | LFLNKTDNGTYRCEA EEEECCCCCEEEEEE | 50.35 | UniProtKB CARBOHYD | |
| 423 | Phosphorylation | AIINAEGSQVNAEEK EEEECCCCCCCHHHH | 23.59 | 24719451 | |
| 425 | Phosphorylation | INAEGSQVNAEEKKE EECCCCCCCHHHHHH | 8.63 | 24719451 | |
| 433 | Phosphorylation | NAEEKKEYFI----- CHHHHHHHCC----- | 18.56 | 27196784 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CADM2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CADM2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CADM2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CADM2_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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