RAB6B_HUMAN - dbPTM
RAB6B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAB6B_HUMAN
UniProt AC Q9NRW1
Protein Name Ras-related protein Rab-6B
Gene Name RAB6B
Organism Homo sapiens (Human).
Sequence Length 208
Subcellular Localization Golgi apparatus membrane
Lipid-anchor . Endoplasmic reticulum-Golgi intermediate compartment . Cytoplasmic vesicle . Colocalizes with BICD1 at vesicular structures that align along microtubules.
Protein Description Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells..
Protein Sequence MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQQTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTGYNVKQLFRRVASALPGMENVQEKSKEGMIDIKLDKPQEPPASEGGCSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSAGGDFGN
------CCCCCCCCC		35.3028355574
23PhosphorylationLVFLGEQSVGKTSLI
EEEEECCCCCCCHHH		28.6529255136
26UbiquitinationLGEQSVGKTSLITRF
EECCCCCCCHHHHHH		32.5533845483
28PhosphorylationEQSVGKTSLITRFMY
CCCCCCCHHHHHHHH		22.6624719451
35PhosphorylationSLITRFMYDSFDNTY
HHHHHHHHHCCCCCE		13.01-
37PhosphorylationITRFMYDSFDNTYQA
HHHHHHHCCCCCEEE		19.6029978859
41PhosphorylationMYDSFDNTYQATIGI
HHHCCCCCEEEEEEE		20.8929978859
42PhosphorylationYDSFDNTYQATIGID
HHCCCCCEEEEEEEE		11.4729978859
45PhosphorylationFDNTYQATIGIDFLS
CCCCEEEEEEEEECC		12.2929978859
52PhosphorylationTIGIDFLSKTMYLED
EEEEEECCCCCEECC		26.5224719451
54PhosphorylationGIDFLSKTMYLEDRT
EEEECCCCCEECCCE		13.9921712546
56PhosphorylationDFLSKTMYLEDRTVR
EECCCCCEECCCEEE		16.5125884760
60MethylationKTMYLEDRTVRLQLW
CCCEECCCEEEEEEE		26.24-
61PhosphorylationTMYLEDRTVRLQLWD
CCEECCCEEEEEEEC		23.4629978859
69PhosphorylationVRLQLWDTAGQERFR
EEEEEECCCCHHHHH		22.5528857561
77PhosphorylationAGQERFRSLIPSYIR
CCHHHHHHHCHHHHC		28.1221406692
81PhosphorylationRFRSLIPSYIRDSTV
HHHHHCHHHHCCCEE		26.6320860994
82PhosphorylationFRSLIPSYIRDSTVA
HHHHCHHHHCCCEEE		8.4621406692
82AMPylationFRSLIPSYIRDSTVA
HHHHCHHHHCCCEEE		8.4621822290
82O-AMP-tyrosineFRSLIPSYIRDSTVA
HHHHCHHHHCCCEEE		8.46-
112MethylationSKWIDDVRTERGSDV
HHHHHHHHHHCCCCE		37.55-
113PhosphorylationKWIDDVRTERGSDVI
HHHHHHHHHCCCCEE		29.8624719451
114UbiquitinationWIDDVRTERGSDVII
HHHHHHHHCCCCEEE		44.47-
117PhosphorylationDVRTERGSDVIIMLV
HHHHHCCCCEEEEEE		34.6228348404
127UbiquitinationIIMLVGNKTDLADKR
EEEEECCCCCCCCCC		37.17-
137PhosphorylationLADKRQITIEEGEQR
CCCCCCEEHHHHHHH		17.6321406692
170UbiquitinationVKQLFRRVASALPGM
HHHHHHHHHHHCCCC		4.2632142685
172UbiquitinationQLFRRVASALPGMEN
HHHHHHHHHCCCCHH		27.7330230243
172PhosphorylationQLFRRVASALPGMEN
HHHHHHHHHCCCCHH		27.73-
183UbiquitinationGMENVQEKSKEGMID
CCHHHHHHHHCCCEE		50.1432142685
185UbiquitinationENVQEKSKEGMIDIK
HHHHHHHHCCCEEEE		70.1630230243
206GeranylgeranylationPPASEGGCSC-----
CCCCCCCCCC-----		5.73-
208MethylationASEGGCSC-------
CCCCCCCC-------		8.22-
208GeranylgeranylationASEGGCSC-------
CCCCCCCC-------		8.22-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAB6B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAB6B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAB6B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KI20A_HUMANKIF20Aphysical
10893188
BICL1_MOUSECcdc64physical
20360680
RAB6A_HUMANRAB6Aphysical
28514442
RAB6C_HUMANRAB6Cphysical
28514442
RAE1_HUMANCHMphysical
28514442
GDIA_HUMANGDI1physical
28514442
RAB41_HUMANRAB41physical
28514442
RAE2_HUMANCHMLphysical
28514442
MTMR5_HUMANSBF1physical
28514442
UBP32_HUMANUSP32physical
28514442
CUL9_HUMANCUL9physical
28514442
PGTA_HUMANRABGGTAphysical
28514442
TARB1_HUMANTARBP1physical
28514442
CC117_HUMANCCDC117physical
28514442
PGTB2_HUMANRABGGTBphysical
28514442
MTMR1_HUMANMTMR1physical
28514442
ACOX1_HUMANACOX1physical
28514442
SCPDL_HUMANSCCPDHphysical
28514442
MAVS_HUMANMAVSphysical
28514442
BRE1A_HUMANRNF20physical
28514442
OCRL_HUMANOCRLphysical
28514442
GDIB_HUMANGDI2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAB6B_HUMAN

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Related Literatures of Post-Translational Modification

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