CC117_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC117_HUMAN
• UniProt AC: Q8IWD4
• Protein Name: Coiled-coil domain-containing protein 117
• Gene Name: CCDC117
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Protein Sequence: MAALGRPFSGLPLSGGSDFLQPPQPAFPGRAFPPGADGAELAPRPGPRAVPSSPAGSAARGRVSVHCKKKHKREEEEDDDCPVRKKRITEAELCAGPNDWILCAHQDVEGHGVNPSVSGLSIPGILDVICEEMDQTTGEPQCEVARRKLQEIEDRIIDEDEEVEADRNVNHLPSLVLSDTMKTGLKREFDEVFTKKMIESMSRPSMELVLWKPLPELLSDKPKPSSNTKNYTGESQAKHVAAGTAFPQRTELFSEPRPTGMSLYNSLETATSTEEEMEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AALGRPFSGLPLSGG CCCCCCCCCCCCCCC	41.94	-
14	Phosphorylation	PFSGLPLSGGSDFLQ CCCCCCCCCCCCCCC	38.89	-
17	Phosphorylation	GLPLSGGSDFLQPPQ CCCCCCCCCCCCCCC	28.81	-
48	Methylation	LAPRPGPRAVPSSPA CCCCCCCCCCCCCCC	54.88	-
52	Phosphorylation	PGPRAVPSSPAGSAA CCCCCCCCCCCCCHH	42.21	30266825
53	Phosphorylation	GPRAVPSSPAGSAAR CCCCCCCCCCCCHHC	16.82	30266825
57	Phosphorylation	VPSSPAGSAARGRVS CCCCCCCCHHCCCEE	22.36	30266825
60	Methylation	SPAGSAARGRVSVHC CCCCCHHCCCEEEEE	32.92	-
62	Methylation	AGSAARGRVSVHCKK CCCHHCCCEEEEECH	16.40	-
64	Phosphorylation	SAARGRVSVHCKKKH CHHCCCEEEEECHHH	12.56	-
155	Methylation	KLQEIEDRIIDEDEE HHHHHHHHHCCCCHH	18.25	-
195	Ubiquitination	EFDEVFTKKMIESMS HHHHHHHHHHHHHCC	28.95	-
223	Ubiquitination	ELLSDKPKPSSNTKN HHHCCCCCCCCCCCC	64.37	-
238	Ubiquitination	YTGESQAKHVAAGTA CCCCCHHHHHHCCCC	30.86	-
264	Phosphorylation	RPTGMSLYNSLETAT CCCCHHHHHHHHHCC	8.73	24719451
269	Phosphorylation	SLYNSLETATSTEEE HHHHHHHHCCCCHHH	40.29	24719451
271	Phosphorylation	YNSLETATSTEEEME HHHHHHCCCCHHHHC	43.53	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC117_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC117_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC117_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_HUMAN	HSPA8	physical	26186194
HS71L_HUMAN	HSPA1L	physical	26186194
STIP1_HUMAN	STIP1	physical	26186194
HS90B_HUMAN	HSP90AB1	physical	26186194
HSP74_HUMAN	HSPA4	physical	26186194
OBSL1_HUMAN	OBSL1	physical	26186194
STIP1_HUMAN	STIP1	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
HPBP1_HUMAN	HSPBP1	physical	28514442
BAG1_HUMAN	BAG1	physical	28514442
HS90A_HUMAN	HSP90AA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND MASSSPECTROMETRY.
PubMed: 19690332