OCRL_HUMAN - dbPTM
OCRL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OCRL_HUMAN
UniProt AC Q01968
Protein Name Inositol polyphosphate 5-phosphatase OCRL-1
Gene Name OCRL
Organism Homo sapiens (Human).
Sequence Length 901
Subcellular Localization Cytoplasmic vesicle, phagosome membrane . Early endosome membrane . Membrane, clathrin-coated pit . Cell projection, cilium, photoreceptor outer segment . Cell projection, cilium . Cytoplasmic vesicle . Endosome . Golgi apparatus, trans-Golgi network . No
Protein Description Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. [PubMed: 25869668]
Protein Sequence MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINSHFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQLLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQMVPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
127 (in isoform 2)Ubiquitination-58.8921890473
127 (in isoform 1)Ubiquitination-58.8921890473
127UbiquitinationQLLVPEQKDSSSWYQ
CCCCCCCCCCCHHHH		58.8921890473
127UbiquitinationQLLVPEQKDSSSWYQ
CCCCCCCCCCCHHHH		58.8921890473
127UbiquitinationQLLVPEQKDSSSWYQ
CCCCCCCCCCCHHHH		58.8921890473
133PhosphorylationQKDSSSWYQKLDTKD
CCCCCHHHHHCCCCC		9.5625884760
135UbiquitinationDSSSWYQKLDTKDKP
CCCHHHHHCCCCCCC		32.41-
138PhosphorylationSWYQKLDTKDKPSVF
HHHHHCCCCCCCCHH		52.13-
156PhosphorylationLGFEDNFSSMNLDKK
CCCCCCCCCCCCCHH		34.6328348404
157PhosphorylationGFEDNFSSMNLDKKI
CCCCCCCCCCCCHHH		13.9328348404
163UbiquitinationSSMNLDKKINSQNQP
CCCCCCHHHCCCCCC		46.95-
183PhosphorylationEPPPPPFSVNKMLPR
CCCCCCCCHHHCCCC		30.4725159151
208UbiquitinationKVTNTMRKLFVPNTQ
CCCHHHHHHCCCCCC		35.14-
234PhosphorylationLAKREKEYVNIQTFR
HHHHHHHCCCEEEEE		15.1827642862
346PhosphorylationIATETVGTGIMGKMG
HCCCCCCCCHHHCCC		21.14-
349SulfoxidationETVGTGIMGKMGNKG
CCCCCCHHHCCCCCC		4.4621406390
351UbiquitinationVGTGIMGKMGNKGGV
CCCCHHHCCCCCCCE		26.67-
390PhosphorylationFERRNQDYKDICARM
HHHHCCCHHHHHHHH		10.78-
391UbiquitinationERRNQDYKDICARMS
HHHCCCHHHHHHHHC		49.24-
398PhosphorylationKDICARMSFVVPNQT
HHHHHHHCEECCCCC		14.8826657352
405PhosphorylationSFVVPNQTLPQLNIM
CEECCCCCCCCCCCC		47.2326657352
437PhosphorylationPDANEVKSLINKKDL
CCHHHHHHHCCHHHH		39.3924719451
449UbiquitinationKDLQRLLKFDQLNIQ
HHHHHHHHHHHHCCC		52.0321890473
449 (in isoform 1)Ubiquitination-52.0321890473
449UbiquitinationKDLQRLLKFDQLNIQ
HHHHHHHHHHHHCCC		52.0321890473
449UbiquitinationKDLQRLLKFDQLNIQ
HHHHHHHHHHHHCCC		52.0321890473
449 (in isoform 2)Ubiquitination-52.0321890473
461 (in isoform 2)Ubiquitination-36.9221890473
461 (in isoform 1)Ubiquitination-36.9221890473
461UbiquitinationNIQRTQKKAFVDFNE
CCCCCCCEEEECCCC		36.9221890473
461UbiquitinationNIQRTQKKAFVDFNE
CCCCCCCEEEECCCC		36.9221890473
461UbiquitinationNIQRTQKKAFVDFNE
CCCCCCCEEEECCCC		36.9221890473
472UbiquitinationDFNEGEIKFIPTYKY
CCCCCEEEEEEEEEC		32.70-
478UbiquitinationIKFIPTYKYDSKTDR
EEEEEEEECCCCCCC		45.09-
479PhosphorylationKFIPTYKYDSKTDRW
EEEEEEECCCCCCCC		18.2929759185
483PhosphorylationTYKYDSKTDRWDSSG
EEECCCCCCCCCCCC		34.4529759185
513PhosphorylationTNVNQLNYRSHMELK
CCHHHCHHCCCEEEE		23.2924425749
528PhosphorylationTSDHKPVSALFHIGV
CCCCCCCHHHEEECE		27.99-
545UbiquitinationVDERRYRKVFEDSVR
CCHHHHHHHHHHHHH		42.20-
545MalonylationVDERRYRKVFEDSVR
CCHHHHHHHHHHHHH		42.2032601280
578UbiquitinationEFVFENVKFRQLQKE
HHHHCCCHHHHHHHH		46.5421890473
578 (in isoform 1)Ubiquitination-46.5421890473
578UbiquitinationEFVFENVKFRQLQKE
HHHHCCCHHHHHHHH		46.5421890473
578UbiquitinationEFVFENVKFRQLQKE
HHHHCCCHHHHHHHH		46.542189047
578 (in isoform 2)Ubiquitination-46.5421890473
586UbiquitinationFRQLQKEKFQISNNG
HHHHHHHCEECCCCC		49.99-
608PhosphorylationFIPKLNDSQYCKPWL
ECCCCCCCCCCCHHC		23.2120873877
610PhosphorylationPKLNDSQYCKPWLRA
CCCCCCCCCCHHCCC		13.3420873877
612UbiquitinationLNDSQYCKPWLRAEP
CCCCCCCCHHCCCCC		34.00-
701 (in isoform 2)Ubiquitination-43.6121890473
701UbiquitinationIREVPVTKLIDLEED
CCCCCCEEEECCCCC		43.61-
701UbiquitinationIREVPVTKLIDLEED
CCCCCCEEEECCCCC		43.6121890473
709PhosphorylationLIDLEEDSFLEKEKS
EECCCCCCHHHHHHH		34.7023403867
713UbiquitinationEEDSFLEKEKSLLQM
CCCCHHHHHHHHHHC		73.01-
716PhosphorylationSFLEKEKSLLQMVPL
CHHHHHHHHHHCCCC		35.0922199227
728PhosphorylationVPLDEGASERPLQVP
CCCCCCCCCCCCCCC		45.0228857561
838PhosphorylationCHRNVFRYLMAFLRE
HHHHHHHHHHHHHHH		6.8622817900
880PhosphorylationPNLMARQTPSDRQRA
CCCCCCCCCCHHHHH		21.14-
882PhosphorylationLMARQTPSDRQRAIQ
CCCCCCCCHHHHHHH		49.14-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OCRL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OCRL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OCRL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GOGA5_HUMANGOLGA5physical
9915833
RAB1A_HUMANRAB1Aphysical
16902405
RAB5A_HUMANRAB5Aphysical
16902405
RAB6A_HUMANRAB6Aphysical
16902405
RAB8A_HUMANRAB8Aphysical
16902405
RAB14_HUMANRAB14physical
16902405
CLH1_HUMANCLTCphysical
16902405
PKHJ1_HUMANPLEKHJ1physical
28514442
I5P2_HUMANINPP5Bphysical
28514442
PAK2_HUMANPAK2physical
28514442
AP2A1_HUMANAP2A1physical
28514442
RAB6A_HUMANRAB6Aphysical
28514442
PCBP3_HUMANPCBP3physical
28514442
CLCA_HUMANCLTAphysical
27173435
CLCB_HUMANCLTBphysical
27173435
DP13A_HUMANAPPL1physical
27173435
EIFCL_HUMANEIF3CLphysical
27173435
SNX9_HUMANSNX9physical
27173435
AP2B1_HUMANAP2B1physical
27173435
EIF3E_HUMANEIF3Ephysical
27173435
RAB6A_HUMANRAB6Aphysical
27173435
SNX33_HUMANSNX33physical
27173435
AP2S1_HUMANAP2S1physical
27173435
AP2M1_HUMANAP2M1physical
27173435
Drug and Disease Associations
Kegg Disease
H00692 Lowe syndrome; Oculocerebrorenal Dystrophy (OCRL)
H00694 Dent disease, including: Dent disease 1; Dent disease 2; X-linked recessive nephrolithiasis ; Hypoph
OMIM Disease
309000Lowe oculocerebrorenal syndrome (OCRL)
300555Dent disease 2 (DD2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OCRL_HUMAN

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