PKHJ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PKHJ1_HUMAN
• UniProt AC: Q9NW61
• Protein Name: Pleckstrin homology domain-containing family J member 1
• Gene Name: PLEKHJ1
• Organism: Homo sapiens (Human).
• Sequence Length: 149
• Protein Sequence: MRYNEKELQALSRQPAEMAAELGMRGPKKGSVLKRRLVKLVVNFLFYFRTDEAEPVGALLLERCRVVREEPGTFSISFIEDPERKYHFECSSEEQCQEWMEALRRASYEFMRRSLIFYRNEIRKVTGKDPLEQFGISEEARFQLSGLQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MRYNEKELQALSR --CCCCHHHHHHHHH	61.15	21890473
31	Phosphorylation	MRGPKKGSVLKRRLV CCCCCCCCHHHHHHH	32.91	24719451
86	Phosphorylation	IEDPERKYHFECSSE EECCCCCEECCCCCH	20.26	-
108	Phosphorylation	EALRRASYEFMRRSL HHHHHHCHHHHHHHH	16.52	-
118	Phosphorylation	MRRSLIFYRNEIRKV HHHHHHHHHHHHHHH	12.92	17924679
128	Ubiquitination	EIRKVTGKDPLEQFG HHHHHHCCCHHHHCC	46.97	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PKHJ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PKHJ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PKHJ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KT33B_HUMAN	KRT33B	physical	17353931
SESQ1_HUMAN	FAM109A	physical	21900206
DNM3B_HUMAN	DNMT3B	physical	21900206
CXCL7_HUMAN	PPBP	physical	21900206
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-118, AND MASSSPECTROMETRY.
PubMed: 17924679