RAB41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB41_HUMAN
• UniProt AC: Q5JT25
• Protein Name: Ras-related protein Rab-41
• Gene Name: RAB41
• Organism: Homo sapiens (Human).
• Sequence Length: 222
• Subcellular Localization: Cytoplasm . punctate localization concentrated in ruffled regions at the cell periphery.
• Protein Description: Required for normal Golgi ribbon organization and ER-to-Golgi trafficking..
• Protein Sequence: MSAFGHDEAWMEAGGFGLEAAERTEYQSLCKSKLLFLGEQSVGKTSIISRFMYNSFGCACQATVGIDFLSKTMYLEDQIVQLQLWDTAGQERFHSLIPSYIRDSTIAVVVYDITNINSFKETDKWVEHVRAERGDDVVIMLLGNKIDLDNKRQVTAEQGEEKSRNLNVMFIETSAKTGYNVKKLFRRVASALLSTRTSPPPKEGTVEIELESFEESGNRSYC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45 (in isoform 2)	Phosphorylation	-	21.16	-
46	Phosphorylation	EQSVGKTSIISRFMY CCCCCCHHHHHHHHH	22.78	24719451
49	Phosphorylation	VGKTSIISRFMYNSF CCCHHHHHHHHHHCC	20.14	24719451
87	Phosphorylation	VQLQLWDTAGQERFH EEEEECCCCCHHHHH	22.55	28857561
95	Phosphorylation	AGQERFHSLIPSYIR CCHHHHHHHCHHHHC	25.86	21406692
99	Phosphorylation	RFHSLIPSYIRDSTI HHHHHCHHHHCCCEE	26.63	20860994
100	Phosphorylation	FHSLIPSYIRDSTIA HHHHCHHHHCCCEEE	8.46	21406692
104	Phosphorylation	IPSYIRDSTIAVVVY CHHHHCCCEEEEEEE	16.32	29083192
105	Phosphorylation	PSYIRDSTIAVVVYD HHHHCCCEEEEEEEE	19.76	29083192
111	Phosphorylation	STIAVVVYDITNINS CEEEEEEEECCCCCC	7.04	29083192
145	Methylation	VIMLLGNKIDLDNKR EEEECCCEECCCCCC	35.48	-
174	Phosphorylation	NVMFIETSAKTGYNV EEEEEECCCCCCCCH	18.25	29083192
177	Phosphorylation	FIETSAKTGYNVKKL EEECCCCCCCCHHHH	44.61	22210691
179	Phosphorylation	ETSAKTGYNVKKLFR ECCCCCCCCHHHHHH	23.24	22817900
190	Phosphorylation	KLFRRVASALLSTRT HHHHHHHHHHHCCCC	19.32	26657352
198	Phosphorylation	ALLSTRTSPPPKEGT HHHCCCCCCCCCCCE	31.92	24719451
222	Geranylgeranylation	ESGNRSYC------- HCCCCCCC-------	4.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB41_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB41_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PPP5_HUMAN	PPP5C	physical	28514442
FEM1B_HUMAN	FEM1B	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.