CBPE_HUMAN - dbPTM
CBPE_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CBPE_HUMAN
UniProt AC P16870
Protein Name Carboxypeptidase E
Gene Name CPE
Organism Homo sapiens (Human).
Sequence Length 476
Subcellular Localization Isoform 1: Cytoplasmic vesicle, secretory vesicle membrane
Peripheral membrane protein . Secreted . Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions.
Isoform 2: Nucleus .
Protein Description Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin..
Protein Sequence MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
65PhosphorylationELREALVSVWLQCTA
HHHHHHHHHHHHHHH		14.3929759185
71PhosphorylationVSVWLQCTAISRIYT
HHHHHHHHHHHEEEE		17.6729759185
74PhosphorylationWLQCTAISRIYTVGR
HHHHHHHHEEEEECC		15.3429759185
139N-linked_GlycosylationCNEYQKGNETIVNLI
HHHHHHCCHHHHHHH		50.72UniProtKB CARBOHYD
164UbiquitinationLNPDGFEKAASQPGE
CCCCCHHHHHCCCCC		47.1721906983
173UbiquitinationASQPGELKDWFVGRS
HCCCCCCCCCCCCCC		48.9221906983
203UbiquitinationRIVYVNEKEGGPNNH
EEEEEECCCCCCCCH		57.3621906983
224UbiquitinationKIVDQNTKLAPETKA
HHHCCCCCCCHHHHH		50.6421906983
260UbiquitinationVANYPYDETRSGSAH
EECCCCCCCCCCCCC		40.0321906983
265PhosphorylationYDETRSGSAHEYSSS
CCCCCCCCCCCCCCC		27.9124505115
269UbiquitinationRSGSAHEYSSSPDDA
CCCCCCCCCCCHHHH		12.1821906983
285PhosphorylationFQSLARAYSSFNPAM
HHHHHHHHHHCCCCC		10.1724114839
286PhosphorylationQSLARAYSSFNPAMS
HHHHHHHHHCCCCCC		27.7124114839
299UbiquitinationMSDPNRPPCRKNDDD
CCCCCCCCCCCCCCC		27.5821906983
320UbiquitinationTTNGGAWYSVPGGMQ
CCCCCCEEECCCCCC		10.1521906983
364PhosphorylationYWEDNKNSLISYLEQ
HHHCCCCCHHHHHHH		28.7924719451
368PhosphorylationNKNSLISYLEQIHRG
CCCCHHHHHHHHHHH		13.7824719451
390N-linked_GlycosylationLQGNPIANATISVEG
CCCCCCCCEEEEEEC		38.03UniProtKB CARBOHYD
392PhosphorylationGNPIANATISVEGID
CCCCCCEEEEEECCC		17.37-
394PhosphorylationPIANATISVEGIDHD
CCCCEEEEEECCCCC		15.12-
403PhosphorylationEGIDHDVTSAKDGDY
ECCCCCCCCCCCCCE		29.08-
404PhosphorylationGIDHDVTSAKDGDYW
CCCCCCCCCCCCCEE		32.92-
406UbiquitinationDHDVTSAKDGDYWRL
CCCCCCCCCCCEEEE		63.1121906983
422PhosphorylationIPGNYKLTASAPGYL
ECCCEEEEECCCCEE		17.89-
428PhosphorylationLTASAPGYLAITKKV
EEECCCCEEEEEEEE		7.60-
432PhosphorylationAPGYLAITKKVAVPY
CCCEEEEEEEEECCC		21.14-
433UbiquitinationPGYLAITKKVAVPYS
CCEEEEEEEEECCCC		38.852190698
433MethylationPGYLAITKKVAVPYS
CCEEEEEEEEECCCC		38.85-
502Ubiquitination---------------------------------
---------------------------------		21906983
529Ubiquitination------------------------------------------------------------
------------------------------------------------------------		21906983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CBPE_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CBPE_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CBPE_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ROBO2_HUMANROBO2physical
16169070
CHD3_HUMANCHD3physical
16169070
TF3C1_HUMANGTF3C1physical
16169070
DPOA2_HUMANPOLA2physical
16169070
PDIP2_HUMANPOLDIP2physical
16169070
RFA1_HUMANRPA1physical
16169070
UT14A_HUMANUTP14Aphysical
16169070
MED31_HUMANMED31physical
16169070
LRIF1_HUMANLRIF1physical
16169070
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00030Insulin Regular
Regulatory Network of CBPE_HUMAN

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Related Literatures of Post-Translational Modification

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