ROBO2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ROBO2_HUMAN
• UniProt AC: Q9HCK4
• Protein Name: Roundabout homolog 2
• Gene Name: ROBO2
• Organism: Homo sapiens (Human).
• Sequence Length: 1378
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development..
• Protein Sequence: MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLMFTQL ------CCHHHHHHH	41.33	24043423
7	Phosphorylation	-MSLLMFTQLLLCGF -CCHHHHHHHHHHCC	12.35	24719451
16	Phosphorylation	LLLCGFLYVRVDGSR HHHHCCEEEEECCHH	5.50	24043423
22	Phosphorylation	LYVRVDGSRLRQEDF EEEEECCHHHCCCCC	24.55	24043423
38 (in isoform 3)	Phosphorylation	-	46.55	24719451
65	Phosphorylation	PTPTIEWYKDGERVE CCCCEEEEECCCEEE	6.09	-
123	N-linked_Glycosylation	LGEAVSRNASLEVAL CCHHHHCCCCCEEEE	26.78	UniProtKB CARBOHYD
201	Phosphorylation	RKSDAGMYTCVGTNM CHHCCCCEEEECCCC	8.96	-
270	Phosphorylation	ADLPRGRYDIKDDYT CCCCCCCCCCCCCEE	25.50	18083107
276	Phosphorylation	RYDIKDDYTLRIKKT CCCCCCCEEEEEEEE	20.15	-
277	Phosphorylation	YDIKDDYTLRIKKTM CCCCCCEEEEEEEEE	19.29	24719451
305	Phosphorylation	RVGKMEASATLTVRA CCCEEEECEEEEECC	14.42	24114839
409	Phosphorylation	AKAQLEVTDVLTDRP HHEEEEEEECCCCCC	15.83	22210691
413	Phosphorylation	LEVTDVLTDRPPPII EEEEECCCCCCCCEE	29.79	22210691
426	N-linked_Glycosylation	IILQGPANQTLAVDG EEEECCCCCEEEECC	38.20	UniProtKB CARBOHYD
428	Phosphorylation	LQGPANQTLAVDGTA EECCCCCEEEECCCE	19.25	22210691
434	Phosphorylation	QTLAVDGTALLKCKA CEEEECCCEEEEEEE	15.07	22210691
580	Phosphorylation	NHVKTTLYTVRGLRP HHHHEEEEECCCCCC	10.90	-
615	Phosphorylation	PMSDPVRTQDISPPA CCCCCCCCCCCCCCC	30.72	29970186
680	Phosphorylation	RQTSGLQATSSWQNL ECCCCCCCCCCCCCC	17.94	32142685
715	Phosphorylation	YEIKVRPYFNEFQGM EEEEEECCCCCCCCC	14.42	29209046
724	Phosphorylation	NEFQGMDSESKTVRT CCCCCCCCCCCEEEC	34.57	29209046
726	Phosphorylation	FQGMDSESKTVRTTE CCCCCCCCCEEECCC	37.26	29209046
728	Phosphorylation	GMDSESKTVRTTEEA CCCCCCCEEECCCCC	25.21	29209046
732	Phosphorylation	ESKTVRTTEEAPSAP CCCEEECCCCCCCCC	22.67	32142685
752	N-linked_Glycosylation	VLTVGSYNSTSISVS EEEECCCCCCEEEEE	40.27	UniProtKB CARBOHYD
782	N-linked_Glycosylation	YKIWCLGNETRFHIN EEEEECCCCCEECCC	34.22	UniProtKB CARBOHYD
789	N-linked_Glycosylation	NETRFHINKTVDAAI CCCEECCCHHHHHHH	25.94	UniProtKB CARBOHYD
791	Phosphorylation	TRFHINKTVDAAIRS CEECCCHHHHHHHHH	21.09	-
845	N-linked_Glycosylation	EVVITENNNSITEQI EEEEECCCCCHHHHH	37.08	UniProtKB CARBOHYD
893	Phosphorylation	KRKGLSNYAVTFQRG HCCCCCCEEEEEECC	10.08	25884760
906	Phosphorylation	RGDGGLMSNGSRPGL CCCCCCCCCCCCCCC	42.98	22210691
909	Phosphorylation	GGLMSNGSRPGLLNA CCCCCCCCCCCCCCC	39.28	22210691
966	Phosphorylation	GQGDKTATMLSDGAI CCCCCCEEEECCCCE	24.71	30576142
969	Phosphorylation	DKTATMLSDGAIYSS CCCEEEECCCCEEEE	24.15	30576142
974	Phosphorylation	MLSDGAIYSSIDFTT EECCCCEEEEEEECC	8.88	30576142
985	Phosphorylation	DFTTKTSYNSSSQIT EECCCCCCCCCCCEE	25.05	25884760
995	Phosphorylation	SSQITQATPYATTQI CCCEEECCCCCCHHH	13.65	28348404
997	Phosphorylation	QITQATPYATTQILH CEEECCCCCCHHHHC	16.54	25884760
999	Phosphorylation	TQATPYATTQILHSN EECCCCCCHHHHCCC	17.25	28348404
1000	Phosphorylation	QATPYATTQILHSNS ECCCCCCHHHHCCCC	12.87	28348404
1005	Phosphorylation	ATTQILHSNSIHELA CCHHHHCCCCCEEEE	28.91	28348404
1007	Phosphorylation	TQILHSNSIHELAVD HHHHCCCCCEEEEEC	28.47	28348404
1013	Phosphorylation	NSIHELAVDLPDPQW CCCEEEEECCCCHHH	14.02	27251275
1035	Phosphorylation	TDLMGFGYSLPDQNK HCCCCCCCCCCCCCC	12.55	25884760
1036	Phosphorylation	DLMGFGYSLPDQNKG CCCCCCCCCCCCCCC	33.53	29978859
1059	Phosphorylation	KKKNKNSSKPQKNNG CCCCCCCCCCCCCCC	58.72	23532336
1139	Phosphorylation	PPVRGVASSPAISFG CCCCCCCCCCCEECC	34.15	26699800
1140	Phosphorylation	PVRGVASSPAISFGQ CCCCCCCCCCEECCC	14.49	26699800
1144	Phosphorylation	VASSPAISFGQQSTA CCCCCCEECCCCCCC	25.98	30206219
1149	Phosphorylation	AISFGQQSTATLTPS CEECCCCCCCCCCCC	16.48	30206219
1150	Phosphorylation	ISFGQQSTATLTPSP EECCCCCCCCCCCCH	21.23	30206219
1152	Phosphorylation	FGQQSTATLTPSPRE CCCCCCCCCCCCHHH	31.11	30206219
1154	Phosphorylation	QQSTATLTPSPREEM CCCCCCCCCCHHHHH	19.84	30206219
1156	Phosphorylation	STATLTPSPREEMQP CCCCCCCCHHHHHHH	31.21	28348404
1176	Phosphorylation	LDELTRAYQFDIAKQ HHHHHHHHCCCHHHE	13.36	25884760
1240	Phosphorylation	PLRALDQTPGSSMDN CHHHHCCCCCCCCCC	29.32	28348404
1243	Phosphorylation	ALDQTPGSSMDNLDS HHCCCCCCCCCCCCH	24.56	28348404
1244	Phosphorylation	LDQTPGSSMDNLDSS HCCCCCCCCCCCCHH	35.75	24719451
1260	Phosphorylation	TGKAFTSSQRPRPTS CCCCCCCCCCCCCCC	27.44	24719451
1266	Phosphorylation	SSQRPRPTSPFSTDS CCCCCCCCCCCCCCC	50.76	28348404
1267	Phosphorylation	SQRPRPTSPFSTDSN CCCCCCCCCCCCCCC	26.99	25884760
1270	Phosphorylation	PRPTSPFSTDSNTSA CCCCCCCCCCCCHHH	34.39	29449344
1271	Phosphorylation	RPTSPFSTDSNTSAA CCCCCCCCCCCHHHH	43.77	29449344
1273	Phosphorylation	TSPFSTDSNTSAALS CCCCCCCCCHHHHHC	41.94	32142685
1275	Phosphorylation	PFSTDSNTSAALSQS CCCCCCCHHHHHCCC	24.56	29449344
1276	Phosphorylation	FSTDSNTSAALSQSQ CCCCCCHHHHHCCCC	18.78	29449344
1277	Phosphorylation	STDSNTSAALSQSQR CCCCCHHHHHCCCCC	15.47	32142685
1280	Phosphorylation	SNTSAALSQSQRPRP CCHHHHHCCCCCCCC	24.06	29449344
1282	Phosphorylation	TSAALSQSQRPRPTK HHHHHCCCCCCCCCC	25.44	29449344
1288	Phosphorylation	QSQRPRPTKKHKGGR CCCCCCCCCCCCCCC	54.74	29449344
1289	Phosphorylation	SQRPRPTKKHKGGRM CCCCCCCCCCCCCCC	56.41	32142685
1325	Phosphorylation	YSKPSFPSPGGHSSS CCCCCCCCCCCCCCC	33.88	25159151
1329	Phosphorylation	SFPSPGGHSSSGTAS CCCCCCCCCCCCCCC	30.35	32142685
1338	Phosphorylation	SSGTASSKGSTGPRK CCCCCCCCCCCCCCC	55.15	32142685
1340	Phosphorylation	GTASSKGSTGPRKTE CCCCCCCCCCCCCHH	33.65	25278378
1341	Phosphorylation	TASSKGSTGPRKTEV CCCCCCCCCCCCHHH	60.93	32142685
1346	Phosphorylation	GSTGPRKTEVLRAGH CCCCCCCHHHHHHHC	32.38	25278378
1390	Phosphorylation	------------------- -------------------		32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ROBO2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ROBO2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ROBO2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ROBO2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H01037: Vesicoureteral reflux
• OMIM Disease
• 610878: Vesicoureteral reflux 2 (VUR2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.