dbPTM

PLXA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLXA2_HUMAN
UniProt AC	O75051
Protein Name	Plexin-A2
Gene Name	PLXNA2
Organism	Homo sapiens (Human).
Sequence Length	1894
Subcellular Localization	Cell membrane Single-pass type I membrane protein.
Protein Description	Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)..
Protein Sequence	MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PRALEVDSRSVVLLS CCCCCCCCHHHHEEE	31.47	24719451
49	Phosphorylation	HSENRDWTFNHLTVH CCCCCCEEEEEEEEE	20.88	29978859
54	Phosphorylation	DWTFNHLTVHQGTGA CEEEEEEEEECCCCE	14.37	29978859
59	Phosphorylation	HLTVHQGTGAVYVGA EEEEECCCCEEEEEE	18.52	29978859
63	Phosphorylation	HQGTGAVYVGAINRV ECCCCEEEEEECCEE	7.82	29978859
76	N-linked_Glycosylation	RVYKLTGNLTIQVAH EEEEEECCEEEEEEE	28.86	UniProtKB CARBOHYD
91	N-linked_Glycosylation	KTGPEEDNKSCYPPL CCCCCCCCCCCCCCE	41.23	UniProtKB CARBOHYD
138	Acetylation	SLYQGVCKLLRLDDL HHHHHHHHHHCCCCE	48.42	19828253
154	Acetylation	ILVEPSHKKEHYLSS EEECCCCCCCEEEEC	65.28	7978527
197	Phosphorylation	GKQDYFPTLSSRKLP CCCCCCCCCCCCCCC	29.40	26471730
199	Phosphorylation	QDYFPTLSSRKLPRD CCCCCCCCCCCCCCC	30.49	26471730
200	Phosphorylation	DYFPTLSSRKLPRDP CCCCCCCCCCCCCCC	36.23	26471730
224	Phosphorylation	LHSDFVSSLIKIPSD ECHHHHHHHCCCCHH	28.89	24719451
293	Phosphorylation	DDPKFHSYVSLPFGC CCCCCCCEECCCCCC	5.86	-
295	Phosphorylation	PKFHSYVSLPFGCTR CCCCCEECCCCCCCC	23.30	-
327	N-linked_Glycosylation	DSLAQAFNITSQDDV CCHHHHCCCCCCCCE	39.38	UniProtKB CARBOHYD
340	Phosphorylation	DVLFAIFSKGQKQYH CEEEEEEECCCCCCC	29.75	24719451
434	Phosphorylation	TSRDRMTSVASYVYN CCCCCCHHHHHHHHC	13.32	-
444	Phosphorylation	SYVYNGYSVVFVGTK HHHHCCEEEEEEEEC	17.13	-
470	Phosphorylation	PPHGGVQYEMVSVLK CCCCCCEEEEEEEEC	12.00	20363803
474	Phosphorylation	GVQYEMVSVLKDGSP CCEEEEEEEECCCCC	22.03	20363803
598	N-linked_Glycosylation	GIACAFGNLTEVEGQ HEEEECCCCEEEEEE	37.02	UniProtKB CARBOHYD
696	N-linked_Glycosylation	SFQEGRINISEDCPQ CCCCCCEECCCCCCC	30.30	UniProtKB CARBOHYD
756	N-linked_Glycosylation	RVPALRFNSSSVQCQ ECCEEECCCCCEEEC	34.25	UniProtKB CARBOHYD
811	S-palmitoylation	CAAQRESCGLCLKAD HHHCCCCCCEEEECC	4.06	29575903
814	S-palmitoylation	QRESCGLCLKADRKF CCCCCCEEEECCCCE	1.91	29575903
850	Phosphorylation	SPWLDWSSHNVKCSN CCCCCCCCCCEECCC	18.15	-
1205	N-linked_Glycosylation	QLLCEPPNLTGQHKV EEEECCCCCCCCCEE	62.03	UniProtKB CARBOHYD
1222	Phosphorylation	HVGGMVFSPGSVSVI EECCEEECCCCEEEE	19.55	26074081
1225	Phosphorylation	GMVFSPGSVSVISDS CEEECCCCEEEECCC	18.01	26074081
1227	Phosphorylation	VFSPGSVSVISDSLL EECCCCEEEECCCCC	18.54	26074081
1230	Phosphorylation	PGSVSVISDSLLTLP CCCEEEECCCCCCHH	20.99	26074081
1232	Phosphorylation	SVSVISDSLLTLPAI CEEEECCCCCCHHHH	20.63	26074081
1235	Phosphorylation	VISDSLLTLPAIVSI EECCCCCCHHHHHHH	35.67	26074081
1264	Phosphorylation	LIAYKRKSRENDLTL HHHHHHHCCCCCHHH	49.19	-
1272	Ubiquitination	RENDLTLKRLQMQMD CCCCHHHHHHHHHHH	45.91	-
1388	Phosphorylation	RDRGNVASLIMTGLQ CCCCCHHHHHHHCCH	17.72	-
1424	Ubiquitination	LENKNHPKLLLRRTE CCCCCCHHHHHHCCH	44.19	-
1451	Acetylation	FLLHKFLKECAGEPL HHHHHHHHHHCCCHH	54.61	19827435
1483	Phosphorylation	AITGEARYSLSEDKL EECCCEECCCCHHHH	22.47	28102081
1484	Phosphorylation	ITGEARYSLSEDKLI ECCCEECCCCHHHHH	21.62	28102081
1489	Ubiquitination	RYSLSEDKLIRQQIE ECCCCHHHHHHHHHH	41.59	-
1524	Phosphorylation	VKVLNCDTITQVKEK EEEECCCCHHHHHHH	28.29	-
1593	Phosphorylation	HYQVSDRSVVALVPK EEECCCCEEEEEEEC	26.40	25999147
1605	Phosphorylation	VPKQTSSYNIPASAS EECCCCCCCCCCCCE	19.51	25884760
1610	Phosphorylation	SSYNIPASASISRTS CCCCCCCCCEECCCE	19.73	24719451
1612	Phosphorylation	YNIPASASISRTSIS CCCCCCCEECCCEEE	20.71	23403867
1614	Phosphorylation	IPASASISRTSISRY CCCCCEECCCEEECC	27.32	20639409
1621	Phosphorylation	SRTSISRYDSSFRYT CCCEEECCCCCCCCC	17.24	23403867
1623	Phosphorylation	TSISRYDSSFRYTGS CEEECCCCCCCCCCC	23.57	23403867
1624	Phosphorylation	SISRYDSSFRYTGSP EEECCCCCCCCCCCC	15.73	24719451
1627	Phosphorylation	RYDSSFRYTGSPDSL CCCCCCCCCCCCHHH	17.28	23403867
1628	Phosphorylation	YDSSFRYTGSPDSLR CCCCCCCCCCCHHHH	27.25	23403867
1630	Phosphorylation	SSFRYTGSPDSLRSR CCCCCCCCCHHHHHC	20.10	28355574
1633	Phosphorylation	RYTGSPDSLRSRAPM CCCCCCHHHHHCCCC	29.12	19664994
1636	Phosphorylation	GSPDSLRSRAPMITP CCCHHHHHCCCCCCC	37.78	23403867
1670	Phosphorylation	QKEGDRGSKMVSEIY CCCCCHHHHHHHHHH	20.62	24719451
1677	Phosphorylation	SKMVSEIYLTRLLAT HHHHHHHHHHHHHHC	9.66	-
1685	Ubiquitination	LTRLLATKGTLQKFV HHHHHHCHHHHHHHH	44.27	-
1791	Ubiquitination	TSEHRLGKDSPSNKL CCCCCCCCCCCCCCE	60.67	-
1795	Phosphorylation	RLGKDSPSNKLLYAK CCCCCCCCCCEEEEC	51.02	28857561
1797	Ubiquitination	GKDSPSNKLLYAKDI CCCCCCCCEEEECCC	44.18	-
1800	Phosphorylation	SPSNKLLYAKDIPSY CCCCCEEEECCCHHH	23.26	-
1806	Phosphorylation	LYAKDIPSYKSWVER EEECCCHHHHHHHHH	45.59	-
1807	Phosphorylation	YAKDIPSYKSWVERY EECCCHHHHHHHHHH	12.04	-
1814	Phosphorylation	YKSWVERYYADIAKL HHHHHHHHHHHHHHC	6.90	-
1815	Phosphorylation	KSWVERYYADIAKLP HHHHHHHHHHHHHCC	12.20	-
1825	Phosphorylation	IAKLPAISDQDMNAY HHHCCCCCHHHHHHH	31.18	-
1832	Phosphorylation	SDQDMNAYLAEQSRL CHHHHHHHHHHHHHH	11.05	25307156
1837	Phosphorylation	NAYLAEQSRLHAVEF HHHHHHHHHHHHHHH	28.45	25307156
1848	Phosphorylation	AVEFNMLSALNEIYS HHHHHHHHHHHHHHH	21.68	25907765
1854	Phosphorylation	LSALNEIYSYVSKYS HHHHHHHHHHHHHHC	6.43	25907765
1855	Phosphorylation	SALNEIYSYVSKYSE HHHHHHHHHHHHHCH	25.39	25907765
1856	Phosphorylation	ALNEIYSYVSKYSEE HHHHHHHHHHHHCHH	7.56	25907765
1858	Phosphorylation	NEIYSYVSKYSEELI HHHHHHHHHHCHHHH	20.04	25907765
1860	Phosphorylation	IYSYVSKYSEELIGA HHHHHHHHCHHHHHH	17.51	-
1861	Phosphorylation	YSYVSKYSEELIGAL HHHHHHHCHHHHHHH	28.47	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1605	Y	Phosphorylation	Kinase	FYN	P06241	PSP
1677	Y	Phosphorylation	Kinase	FYN	P06241	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PLXA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLXA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP2L_HUMAN	UBAP2L	physical	12421765
FNBP4_HUMAN	FNBP4	physical	12421765
CEMIP_HUMAN	CEMIP	physical	12421765
IFT80_HUMAN	IFT80	physical	12421765
SYF1_HUMAN	XAB2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLXA2_HUMAN

Related Literatures of Post-Translational Modification