dbPTM

FNBP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FNBP4_HUMAN
UniProt AC	Q8N3X1
Protein Name	Formin-binding protein 4
Gene Name	FNBP4
Organism	Homo sapiens (Human).
Sequence Length	1017
Subcellular Localization
Protein Description
Protein Sequence	MGKKSRAVPGRRPILQLSPPGPRGSTPGRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAASDDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKATGGLCLLGAYADSDDDDNDVSEKLAQSKETNGNQSTDIDSTLANFLAEIDAITAPQPAAPVGASAPPPTPPRPEPKEAATSTLSSSTSNGTDSTQTSGWQYDTQCSLAGVGIEMGDWQEVWDENTGCYYYWNTQTNEVTWELPQYLATQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKREVKKEVNEGIQALSNSEEEKKGVAASLLAPLLPEGIKEEEERWRRKVICKEEPVSEVKETSTTVEEATTIVKPQEIMLDNIEDPSQEDLCSVVQSGESEEEEEQDTLELELVLERKKAELRALEEGDGSVSGSSPRSDISQPASQDGMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTPENGETAIGAENSEKIDENSDKEMEVEESPEKIKVQTTPKVEEEQDLKFQIGELANTLTSKFEFLGINRQSISNFHVLLLQTETRIADWREGALNGNYLKRKLQDAAEQLKQYEINATPKGWSCHWDRDHRRYFYVNEQSGESQWEFPDGEEEEEESQAQENRDETLAKQTLKDKTGTDSNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFWTLLQSNVPVLQPPLPLEMPPPPPPPPESPPPPPPPPPPAEDGEIQEVEMEDEGSEEPPAPGTEEDTPLKPSAQTTVVTSQSSVDSTISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQSAIATGHQAAGIGNQATGIGHQTIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVPTATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGRKDKAKKSKTKMPSLVKKWQSIQRELDEEDNSSSSEEDRESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKMAPNT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	RRPILQLSPPGPRGS CCCCEECCCCCCCCC	18.98	29255136
25	Phosphorylation	SPPGPRGSTPGRDPE CCCCCCCCCCCCCCC	32.48	28111955
26	Phosphorylation	PPGPRGSTPGRDPEP CCCCCCCCCCCCCCC	32.36	28111955
67	Phosphorylation	AVTAAAASDDSPSED HHHHHHHCCCCCCHH	36.90	25921289
70	Phosphorylation	AAAASDDSPSEDEQE HHHHCCCCCCHHHHH	35.00	25921289
72	Phosphorylation	AASDDSPSEDEQEAV HHCCCCCCHHHHHHH	62.73	25921289
104	Phosphorylation	RPTAVKATGGLCLLG CCCEEEECCCEEEEE	26.51	29255136
113	Phosphorylation	GLCLLGAYADSDDDD CEEEEEEECCCCCCC	14.78	29255136
116	Phosphorylation	LLGAYADSDDDDNDV EEEEECCCCCCCCCH	34.46	29255136
118	Phosphorylation	GAYADSDDDDNDVSE EEECCCCCCCCCHHH	69.94	32142685
124	Phosphorylation	DDDDNDVSEKLAQSK CCCCCCHHHHHHHCH	31.70	29255136
130	Phosphorylation	VSEKLAQSKETNGNQ HHHHHHHCHHCCCCC	27.18	27542207
133	Phosphorylation	KLAQSKETNGNQSTD HHHHCHHCCCCCCCC	52.76	24043423
138	Phosphorylation	KETNGNQSTDIDSTL HHCCCCCCCCHHHHH	31.86	24043423
139	Phosphorylation	ETNGNQSTDIDSTLA HCCCCCCCCHHHHHH	27.49	24043423
143	Phosphorylation	NQSTDIDSTLANFLA CCCCCHHHHHHHHHH	26.17	24043423
144	Phosphorylation	QSTDIDSTLANFLAE CCCCHHHHHHHHHHH	26.58	24043423
156	Phosphorylation	LAEIDAITAPQPAAP HHHHCCCCCCCCCCC	33.72	26074081
167	Phosphorylation	PAAPVGASAPPPTPP CCCCCCCCCCCCCCC	35.07	26074081
172	Phosphorylation	GASAPPPTPPRPEPK CCCCCCCCCCCCCCH	52.26	26074081
183	Phosphorylation	PEPKEAATSTLSSST CCCHHHCCCCCCCCC	29.32	26074081
184	Phosphorylation	EPKEAATSTLSSSTS CCHHHCCCCCCCCCC	23.71	26074081
185	Phosphorylation	PKEAATSTLSSSTSN CHHHCCCCCCCCCCC	26.72	26074081
187	Phosphorylation	EAATSTLSSSTSNGT HHCCCCCCCCCCCCC	23.49	26074081
188	Phosphorylation	AATSTLSSSTSNGTD HCCCCCCCCCCCCCC	40.52	26074081
189	Phosphorylation	ATSTLSSSTSNGTDS CCCCCCCCCCCCCCC	32.26	26074081
190	Phosphorylation	TSTLSSSTSNGTDST CCCCCCCCCCCCCCC	28.32	26074081
191	Phosphorylation	STLSSSTSNGTDSTQ CCCCCCCCCCCCCCC	34.90	26074081
194	Phosphorylation	SSSTSNGTDSTQTSG CCCCCCCCCCCCCCC	30.90	26074081
283	Phosphorylation	DIYSKEKTISVSSSK CCCCCEEEEECCCCC	21.41	22210691
285	Phosphorylation	YSKEKTISVSSSKSG CCCEEEEECCCCCCC	22.60	23403867
287	Phosphorylation	KEKTISVSSSKSGPV CEEEEECCCCCCCCE	23.31	22210691
288	Phosphorylation	EKTISVSSSKSGPVI EEEEECCCCCCCCEE	39.36	22210691
289	Phosphorylation	KTISVSSSKSGPVIA EEEECCCCCCCCEEE	24.27	22210691
290	Acetylation	TISVSSSKSGPVIAK EEECCCCCCCCEEEE	62.47	25953088
297	Acetylation	KSGPVIAKREVKKEV CCCCEEEEHHHHHHH	37.66	25953088
301	Sumoylation	VIAKREVKKEVNEGI EEEEHHHHHHHHHHH	38.16	25114211
302	Acetylation	IAKREVKKEVNEGIQ EEEHHHHHHHHHHHH	72.56	26051181
312	Phosphorylation	NEGIQALSNSEEEKK HHHHHHHCCCHHHHH	41.13	28348404
314	Phosphorylation	GIQALSNSEEEKKGV HHHHHCCCHHHHHHH	42.90	21815630
324	Phosphorylation	EKKGVAASLLAPLLP HHHHHHHHHHHHHCC	17.74	-
335	Sumoylation	PLLPEGIKEEEERWR HHCCCCCHHHHHHHH	70.68	28112733
348	Sumoylation	WRRKVICKEEPVSEV HHHHEEECCCCCCCC	54.72	-
348	Acetylation	WRRKVICKEEPVSEV HHHHEEECCCCCCCC	54.72	23954790
348	Sumoylation	WRRKVICKEEPVSEV HHHHEEECCCCCCCC	54.72	25114211
358	Phosphorylation	PVSEVKETSTTVEEA CCCCCCCCCCCHHHH	26.17	25599653
360	Phosphorylation	SEVKETSTTVEEATT CCCCCCCCCHHHHEE	42.13	25599653
361	Phosphorylation	EVKETSTTVEEATTI CCCCCCCCHHHHEEE	26.20	25599653
366	Phosphorylation	STTVEEATTIVKPQE CCCHHHHEEEECCHH	21.97	25599653
367	Phosphorylation	TTVEEATTIVKPQEI CCHHHHEEEECCHHE	30.71	25599653
427	Phosphorylation	ALEEGDGSVSGSSPR HHHCCCCCCCCCCCC	20.18	20164059
429	Phosphorylation	EEGDGSVSGSSPRSD HCCCCCCCCCCCCCC	34.35	29255136
431	Phosphorylation	GDGSVSGSSPRSDIS CCCCCCCCCCCCCCC	29.66	29255136
432	Phosphorylation	DGSVSGSSPRSDISQ CCCCCCCCCCCCCCC	28.05	19664994
434	Phosphorylation	SVSGSSPRSDISQPA CCCCCCCCCCCCCCC	49.24	32645325
435	Phosphorylation	VSGSSPRSDISQPAS CCCCCCCCCCCCCCC	42.55	30266825
438	Phosphorylation	SSPRSDISQPASQDG CCCCCCCCCCCCHHH	34.79	30266825
440	Phosphorylation	PRSDISQPASQDGMR CCCCCCCCCCHHHHH	27.39	33259812
442	Phosphorylation	SDISQPASQDGMRRL CCCCCCCCHHHHHHH	35.17	17525332
446	Sulfoxidation	QPASQDGMRRLMSKR CCCCHHHHHHHHHHC	2.79	21406390
451	Phosphorylation	DGMRRLMSKRGKWKM HHHHHHHHHCCCEEE	24.64	-
463	Phosphorylation	WKMFVRATSPESTSR EEEEEEECCCCCCCC	33.96	30266825
464	Phosphorylation	KMFVRATSPESTSRS EEEEEECCCCCCCCC	26.19	30266825
467	Phosphorylation	VRATSPESTSRSSSK EEECCCCCCCCCCCC	34.76	30266825
468	Phosphorylation	RATSPESTSRSSSKT EECCCCCCCCCCCCC	26.88	30266825
469	Phosphorylation	ATSPESTSRSSSKTG ECCCCCCCCCCCCCC	39.17	30266825
471	Phosphorylation	SPESTSRSSSKTGRD CCCCCCCCCCCCCCC	38.44	20363803
472	Phosphorylation	PESTSRSSSKTGRDT CCCCCCCCCCCCCCC	34.44	26074081
473	Phosphorylation	ESTSRSSSKTGRDTP CCCCCCCCCCCCCCC	35.17	20363803
475	Phosphorylation	TSRSSSKTGRDTPEN CCCCCCCCCCCCCCC	39.12	22167270
479	Phosphorylation	SSKTGRDTPENGETA CCCCCCCCCCCCCCC	31.01	29255136
481	Phosphorylation	KTGRDTPENGETAIG CCCCCCCCCCCCCCC	78.82	32142685
485	Phosphorylation	DTPENGETAIGAENS CCCCCCCCCCCCCCH	25.60	23927012
492	Phosphorylation	TAIGAENSEKIDENS CCCCCCCHHHCCCCC	31.60	21815630
499	Phosphorylation	SEKIDENSDKEMEVE HHHCCCCCCCCCEEC	48.27	29255136
508	Phosphorylation	KEMEVEESPEKIKVQ CCCEECCCCCCCEEE	25.50	29255136
516	Phosphorylation	PEKIKVQTTPKVEEE CCCCEEECCCCCCCC	48.32	20201521
517	Phosphorylation	EKIKVQTTPKVEEEQ CCCEEECCCCCCCCC	12.20	25159151
519	Sumoylation	IKVQTTPKVEEEQDL CEEECCCCCCCCCCH	61.25	-
519	Sumoylation	IKVQTTPKVEEEQDL CEEECCCCCCCCCCH	61.25	25114211
527	Ubiquitination	VEEEQDLKFQIGELA CCCCCCHHHHHHHHH	43.44	21963094
529	Ubiquitination	EEQDLKFQIGELANT CCCCHHHHHHHHHHH	40.98	21963094
581	Ubiquitination	NGNYLKRKLQDAAEQ CCHHHHHHHHHHHHH	49.24	29967540
583	Ubiquitination	NYLKRKLQDAAEQLK HHHHHHHHHHHHHHH	41.13	29967540
597	Phosphorylation	KQYEINATPKGWSCH HHCCCCCCCCCCCCE	22.50	21815630
599	Ubiquitination	YEINATPKGWSCHWD CCCCCCCCCCCCEEC	69.52	29967540
601	Ubiquitination	INATPKGWSCHWDRD CCCCCCCCCCEECCC	12.15	29967540
636	Phosphorylation	GEEEEEESQAQENRD CCHHHHHHHHHHHHH	33.81	-
655	Phosphorylation	KQTLKDKTGTDSNST HHHHHCCCCCCCCCC	56.28	30576142
657	Phosphorylation	TLKDKTGTDSNSTES HHHCCCCCCCCCCCC	41.30	21815630
659	Phosphorylation	KDKTGTDSNSTESSE HCCCCCCCCCCCCCC	32.30	28450419
661	Phosphorylation	KTGTDSNSTESSETS CCCCCCCCCCCCCCC	37.19	21815630
662	Phosphorylation	TGTDSNSTESSETST CCCCCCCCCCCCCCC	44.10	21815630
664	Phosphorylation	TDSNSTESSETSTGS CCCCCCCCCCCCCCC	33.30	28450419
665	Phosphorylation	DSNSTESSETSTGSL CCCCCCCCCCCCCCC	38.37	28450419
667	Phosphorylation	NSTESSETSTGSLCK CCCCCCCCCCCCCCC	33.27	30576142
668	Phosphorylation	STESSETSTGSLCKE CCCCCCCCCCCCCCH	27.07	21815630
669	Phosphorylation	TESSETSTGSLCKES CCCCCCCCCCCCCHH	37.90	22817900
671	Phosphorylation	SSETSTGSLCKESFS CCCCCCCCCCCHHHC	30.59	25159151
676	O-linked_Glycosylation	TGSLCKESFSGQVSS CCCCCCHHHCCCCCC	15.37	30059200
678	O-linked_Glycosylation	SLCKESFSGQVSSSS CCCCHHHCCCCCCCC	37.28	30059200
682	O-linked_Glycosylation	ESFSGQVSSSSLMPL HHHCCCCCCCCCCCC	19.33	30059200
683	O-linked_Glycosylation	SFSGQVSSSSLMPLT HHCCCCCCCCCCCCC	25.70	30059200
685	O-linked_Glycosylation	SGQVSSSSLMPLTPF CCCCCCCCCCCCCHH	30.54	30059200
690	O-linked_Glycosylation	SSSLMPLTPFWTLLQ CCCCCCCCHHHHHHH	15.57	30059200
784	Phosphorylation	DSTISSSSSTKGIKR CCCCCCCCCCCCCCC	43.93	25627689
794	O-linked_Glycosylation	KGIKRKATEISTAVV CCCCCCHHHCHHHHH	36.57	30059200
794	Phosphorylation	KGIKRKATEISTAVV CCCCCCHHHCHHHHH	36.57	28555341
797	O-linked_Glycosylation	KRKATEISTAVVQRS CCCHHHCHHHHHHCC	12.23	31373491
797	O-linked_Glycosylation	KRKATEISTAVVQRS CCCHHHCHHHHHHCC	12.23	20068230
797	Phosphorylation	KRKATEISTAVVQRS CCCHHHCHHHHHHCC	12.23	-
798	O-linked_Glycosylation	RKATEISTAVVQRSA CCHHHCHHHHHHCCC	29.18	30059200
804	O-linked_Glycosylation	STAVVQRSATIGSSP HHHHHHCCCCCCCCC	16.81	30059200
809	O-linked_Glycosylation	QRSATIGSSPVLYSQ HCCCCCCCCCEEECC	27.84	30059200
809	Phosphorylation	QRSATIGSSPVLYSQ HCCCCCCCCCEEECC	27.84	28348404
810	O-linked_Glycosylation	RSATIGSSPVLYSQS CCCCCCCCCEEECCH	17.51	30059200
810	Phosphorylation	RSATIGSSPVLYSQS CCCCCCCCCEEECCH	17.51	28348404
821	O-linked_Glycosylation	YSQSAIATGHQAAGI ECCHHHHCCCCCCCC	29.14	30059200
833	O-linked_Glycosylation	AGIGNQATGIGHQTI CCCCCCCCCCCCCCC	21.40	30059200
833	Phosphorylation	AGIGNQATGIGHQTI CCCCCCCCCCCCCCC	21.40	27251275
839	O-linked_Glycosylation	ATGIGHQTIPVSLPA CCCCCCCCCCCCCCC	22.90	30059200
839	Phosphorylation	ATGIGHQTIPVSLPA CCCCCCCCCCCCCCC	22.90	28348404
843	O-linked_Glycosylation	GHQTIPVSLPAAGMG CCCCCCCCCCCCCCC	24.23	30059200
843	Phosphorylation	GHQTIPVSLPAAGMG CCCCCCCCCCCCCCC	24.23	27251275
857	Phosphorylation	GHQARGMSLQSNYLG CHHHCCCCCCCCHHH	26.53	27251275
927	Acetylation	PKMPPPEKTKKGRKD CCCCCCHHCCCCCCH	71.99	25953088
939	Phosphorylation	RKDKAKKSKTKMPSL CCHHHHHHHCCCHHH	44.87	-
945	Phosphorylation	KSKTKMPSLVKKWQS HHHCCCHHHHHHHHH	42.15	-
952	Phosphorylation	SLVKKWQSIQRELDE HHHHHHHHHHHHHCC	21.41	28555341
963	Phosphorylation	ELDEEDNSSSSEEDR HHCCCCCCCCCHHHH	43.87	25159151
964	Phosphorylation	LDEEDNSSSSEEDRE HCCCCCCCCCHHHHH	44.10	25159151
965	Phosphorylation	DEEDNSSSSEEDRES CCCCCCCCCHHHHHH	41.40	21955146
966	Phosphorylation	EEDNSSSSEEDREST CCCCCCCCHHHHHHH	47.13	26055452
972	Phosphorylation	SSEEDRESTAQKRIE CCHHHHHHHHHHHHH	29.91	30108239
973	Phosphorylation	SEEDRESTAQKRIEE CHHHHHHHHHHHHHH	28.49	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FNBP4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FNBP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FNBP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RSMB_HUMAN	SNRPB	physical	11604498
KHDR1_HUMAN	KHDRBS1	physical	11604498

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FNBP4_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432 AND SER-435, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-113; SER-116; SER-432;SER-499 AND SER-508, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-116; SER-432;SER-499; SER-508; THR-517; SER-963; SER-964 AND SER-965, AND MASSSPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-442, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; THR-172; SER-432;SER-499 AND SER-508, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-516, AND MASSSPECTROMETRY.	17287340 [Abstract]