SYPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYPH_HUMAN
• UniProt AC: P08247
• Protein Name: Synaptophysin
• Gene Name: SYP
• Organism: Homo sapiens (Human).
• Sequence Length: 313
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
• Protein Description: Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)..
• Protein Sequence: MLLLADMDVVNQLVAGGQFRVVKEPLGFVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTCRGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATAVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVFGFLNLVLWVGNLWFVFKETGWAAPFLRAPPGAPEKQPAPGDAYGDAGYGQGPGGYGPQDSYGPQGGYQPDYGQPAGSGGSGYGPQGDYGQQGYGPQGAPTSFSNQM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	QLSVDCANKTESDLS EEEEEECCCCCCCCE	59.10	UniProtKB CARBOHYD
73	Phosphorylation	SIEVEFEYPFRLHQV EEEEEEECCCEEEEE	17.00	-
81	Phosphorylation	PFRLHQVYFDAPTCR CCEEEEEEEECCCCC	6.81	24927040
86	Phosphorylation	QVYFDAPTCRGGTTK EEEEECCCCCCCCEE	19.29	24076635
168	Ubiquitination	AKGLSDVKMATDPEN HCCCCCCEECCCHHH	28.01	-
186	Phosphorylation	EMPVCRQTGNTCKEL HCCCCCCCCCCHHHH	17.04	26033855
250	Phosphorylation	QPAPGDAYGDAGYGQ CCCCCCCCCCCCCCC	21.93	25884760
250	Nitration	QPAPGDAYGDAGYGQ CCCCCCCCCCCCCCC	21.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH1	Q8IUQ4	PMID:15064394
-	K	Ubiquitination	E3 ubiquitin ligase	SIAH2	O43255	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:16135753

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP1G1_HUMAN	AP1G1	physical	12498786
SRCN1_HUMAN	SRCIN1	physical	18662323
T183A_HUMAN	TMEM183A	physical	28514442
PTPS_HUMAN	PTS	physical	28514442
SCMC3_HUMAN	SLC25A23	physical	28514442
MRS2_HUMAN	MRS2	physical	28514442
S35B2_HUMAN	SLC35B2	physical	28514442
SFXN3_HUMAN	SFXN3	physical	28514442
S20A2_HUMAN	SLC20A2	physical	28514442
GDC_HUMAN	SLC25A16	physical	28514442
TMTC4_HUMAN	TMTC4	physical	28514442
SGPP1_HUMAN	SGPP1	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
TM87A_HUMAN	TMEM87A	physical	28514442
EXT1_HUMAN	EXT1	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
ERD23_HUMAN	KDELR3	physical	28514442
JIP4_HUMAN	SPAG9	physical	28514442
TM164_HUMAN	TMEM164	physical	28514442
APBB1_HUMAN	APBB1	physical	28514442
S38AA_HUMAN	SLC38A10	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442
ARV1_HUMAN	ARV1	physical	28514442
ARL5B_HUMAN	ARL5B	physical	28514442
GLPK_HUMAN	GK	physical	28514442
RN5A_HUMAN	RNASEL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• H00053: Extraskeletal myxoid chondrosarcoma
• H00577: Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Part
• OMIM Disease
• 300802: Mental retardation, X-linked, SYP-related (MRXSYP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.