T183A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T183A_HUMAN
• UniProt AC: Q8IXX5
• Protein Name: Transmembrane protein 183A
• Gene Name: TMEM183A
• Organism: Homo sapiens (Human).
• Sequence Length: 376
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MARGPGPLGRPRPDTVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAVANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDAQEESIHERTVSRKKKSKRHKEELDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCTGGLQPPVQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	FRAHDACSGRVTVAD EEEECCCCCCEEEHH	31.21	28348404
57	Acetylation	VRSGRVKKAVANAVQ HHCCHHHHHHHHHHH	45.28	7427851
57	Sumoylation	VRSGRVKKAVANAVQ HHCCHHHHHHHHHHH	45.28	-
57	Sumoylation	VRSGRVKKAVANAVQ HHCCHHHHHHHHHHH	45.28	-
96	Phosphorylation	EPCDIIDSSDEMDAQ CCCCCCCCCCCCHHH	29.31	28348404
97	Phosphorylation	PCDIIDSSDEMDAQE CCCCCCCCCCCHHHH	33.57	28348404
183	Phosphorylation	RHYTLDASLPLRLRP HHCCCCCCCCCCCCH	30.13	24719451
202	Ubiquitination	KLRCLRACVIRSLYH HHHHHHHHHHHHHHH	1.80	21963094
203	Ubiquitination	LRCLRACVIRSLYHM HHHHHHHHHHHHHHH	3.88	21963094
205	Ubiquitination	CLRACVIRSLYHMYE HHHHHHHHHHHHHHH	10.54	22817900
206	Ubiquitination	LRACVIRSLYHMYEP HHHHHHHHHHHHHHH	23.35	22817900
220	Ubiquitination	PFAARISKNPAIPES HHHHHHCCCCCCCCC	65.66	-
232	Ubiquitination	PESTPSTLKNSKCLL CCCCCCHHCCCEEEE	6.08	21963094
233 (in isoform 2)	Ubiquitination	-	60.30	21906983
233 (in isoform 1)	Ubiquitination	-	60.30	21906983
233	Ubiquitination	ESTPSTLKNSKCLLF CCCCCHHCCCEEEEE	60.30	27667366
235	Ubiquitination	TPSTLKNSKCLLFWC CCCHHCCCEEEEEHH	24.14	22817900
236	Ubiquitination	PSTLKNSKCLLFWCR CCHHCCCEEEEEHHH	37.99	22817900
336	Phosphorylation	VRLVFQDSPVHGGRK EEEEEECCCCCCCCC	20.31	23186163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T183A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T183A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T183A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.