dbPTM

SRCN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRCN1_HUMAN
UniProt AC	Q9C0H9
Protein Name	SRC kinase signaling inhibitor 1
Gene Name	SRCIN1
Organism	Homo sapiens (Human).
Sequence Length	1183
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Localized to the perinuclear region, lamellopodia, cortical actin
Protein Description	Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance..
Protein Sequence	MGNAPSQDPERSSPPMLSADDAEYPREYRTLGGGGGGGSGGRRFSNVGLVHTSERRHTVIAAQSLEALSGLQKADADRKRDAFMDHLKSKYPQHALALRGQQDRMREQPNYWSFKTRSSRHTQGAQPGLADQAAKLSYASAESLETMSEAELPLGFSRMNRFRQSLPLSRSASQTKLRSPGVLFLQFGEETRRVHITHEVSSLDTLHALIAHMFPQKLTMGMLKSPNTAILIKDEARNVFYELEDVRDIQDRSIIKIYRKEPLYAAFPGSHLTNGDLRREMVYASRESSPTRRLNNLSPAPHLASGSPPPGLPSGLPSGLQSGSPSRSRLSYAGGRPPSYAGSPVHHAAERLGGAPAAQGVSPSPSAILERRDVKPDEDLASKAGGMVLVKGEGLYADPYGLLHEGRLSLAAAAGDPFAYPGAGGLYKRGSVRSLSTYSAAALQSDLEDSLYKAAGGGGPLYGDGYGFRLPPSSPQKLADVAAPPGGPPPPHSPYSGPPSRGSPVRQSFRKDSGSSSVFAESPGGKTRSAGSASTAGAPPSELFPGPGERSLVGFGPPVPAKDTETRERMEAMEKQIASLTGLVQSALLRGSEPETPSEKIEGSNGAATPSAPCGSGGRSSGATPVSGPPPPSASSTPAGQPTAVSRLQMQLHLRGLQNSASDLRGQLQQLRKLQLQNQESVRALLKRTEAELSMRVSEAARRQEDPLQRQRTLVEEERLRYLNDEELITQQLNDLEKSVEKIQRDVSHNHRLVPGPELEEKALVLKQLGETLTELKAHFPGLQSKMRVVLRVEVEAVKFLKEEPQRLDGLLKRCRGVTDTLAQIRRQVDEGVWPPPNNLLSQSPKKVTAETDFNKSVDFEMPPPSPPLNLHELSGPAEGASLTPKGGNPTKGLDTPGKRSVDKAVSVEAAERDWEEKRAALTQYSAKDINRLLEETQAELLKAIPDLDCASKAHPGPAPTPDHKPPKAPHGQKAAPRTEPSGRRGSDELTVPRYRTEKPSKSPPPPPPRRSFPSSHGLTTTRTGEVVVTSKKDSAFIKKAESEELEVQKPQVKLRRAVSEVARPASTPPIMASAIKDEDDEDRIIAELESGGGSVPPMKVVTPGASRLKAAQGQAGSPDKSKHGKQRAEYMRIQAQQQATKPSKEMSGSNETSSPVSEKPSASRTSIPVLTSFGARNSSISF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6 (in isoform 5)	Phosphorylation	-	3.23	-
12 (in isoform 5)	Phosphorylation	-	13.74	27732954
13	Phosphorylation	SQDPERSSPPMLSAD CCCCCCCCCCCCCCC	11.81	-
13 (in isoform 5)	Phosphorylation	-	11.81	27732954
18	Phosphorylation	RSSPPMLSADDAEYP CCCCCCCCCCCCCCC	18.39	-
28 (in isoform 5)	Phosphorylation	-	59.86	28985074
30 (in isoform 5)	Phosphorylation	-	30.38	28176443
39 (in isoform 5)	Phosphorylation	-	42.12	28176443
45	Phosphorylation	GSGGRRFSNVGLVHT CCCCCCCCCCCEEEC	39.84	32142685
45 (in isoform 5)	Phosphorylation	-	39.84	22617229
52	Phosphorylation	SNVGLVHTSERRHTV CCCCEEECCCCCCCE	10.32	24275569
52 (in isoform 5)	Phosphorylation	-	10.32	27251275
53	Phosphorylation	NVGLVHTSERRHTVI CCCEEECCCCCCCEE	18.04	24275569
53 (in isoform 5)	Phosphorylation	-	18.04	27251275
58 (in isoform 5)	Phosphorylation	-	36.64	22617229
64	Phosphorylation	HTVIAAQSLEALSGL CCEEEHHHHHHHHCH	41.73	32142685
64 (in isoform 5)	Phosphorylation	-	41.73	28188228
69 (in isoform 5)	Phosphorylation	-	9.34	25307156
73	Ubiquitination	EALSGLQKADADRKR HHHHCHHHHCHHHHH	23.38	30230243
88	Ubiquitination	DAFMDHLKSKYPQHA HHHHHHHHHHCHHHH	41.97	30230243
89 (in isoform 5)	Phosphorylation	-	46.28	-
97	Phosphorylation	KYPQHALALRGQQDR HCHHHHHHHCCCHHH	21.30	18491316
100	Phosphorylation	QHALALRGQQDRMRE HHHHHHCCCHHHHHC	20.61	18491316
113	Phosphorylation	REQPNYWSFKTRSSR HCCCCCCCCCCCCCC	18.47	27196784
116 (in isoform 5)	Phosphorylation	-	42.39	29116813
118 (in isoform 5)	Phosphorylation	-	4.29	29116813
119 (in isoform 5)	Phosphorylation	-	47.86	29116813
122 (in isoform 5)	Phosphorylation	-	44.33	29116813
125	Phosphorylation	SSRHTQGAQPGLADQ CCCCCCCCCCCHHHH	36.63	24719451
136	Phosphorylation	LADQAAKLSYASAES HHHHHHHHHHHCHHH	13.44	25884760
137 (in isoform 5)	Phosphorylation	-	15.43	29978859
138 (in isoform 5)	Phosphorylation	-	9.52	29978859
140	Phosphorylation	AAKLSYASAESLETM HHHHHHHCHHHHHHC	38.35	32142685
140 (in isoform 5)	Phosphorylation	-	38.35	29978859
142	Phosphorylation	KLSYASAESLETMSE HHHHHCHHHHHHCCC	18.63	28152594
143	Phosphorylation	LSYASAESLETMSEA HHHHCHHHHHHCCCC	42.46	-
143 (in isoform 5)	Phosphorylation	-	42.46	29978859
146 (in isoform 5)	Phosphorylation	-	48.63	28348404
148 (in isoform 5)	Phosphorylation	-	38.79	29978859
155	Phosphorylation	SEAELPLGFSRMNRF CCCCCCCCHHHHHHH	9.50	29759185
157	Phosphorylation	AELPLGFSRMNRFRQ CCCCCCHHHHHHHHH	20.92	24719451
157 (in isoform 5)	Phosphorylation	-	20.92	29978859
163	Phosphorylation	FSRMNRFRQSLPLSR HHHHHHHHHHCCCCC	30.30	28985074
165	Phosphorylation	RMNRFRQSLPLSRSA HHHHHHHHCCCCCCC	44.22	32142685
165 (in isoform 5)	Phosphorylation	-	44.22	30266825
169	Phosphorylation	FRQSLPLSRSASQTK HHHHCCCCCCCCCCC	6.71	-
169 (in isoform 5)	Phosphorylation	-	6.71	22617229
170	Phosphorylation	RQSLPLSRSASQTKL HHHCCCCCCCCCCCC	22.57	27732954
173 (in isoform 5)	Phosphorylation	-	26.80	24719451
175 (in isoform 5)	Phosphorylation	-	3.85	-
177	Phosphorylation	RSASQTKLRSPGVLF CCCCCCCCCCCCEEE	46.28	27362937
179	Phosphorylation	ASQTKLRSPGVLFLQ CCCCCCCCCCEEEEE	31.57	27362937
179 (in isoform 5)	Phosphorylation	-	31.57	24076635
186	Phosphorylation	SPGVLFLQFGEETRR CCCEEEEEECCCEEE	58.99	29116813
190	Phosphorylation	LFLQFGEETRRVHIT EEEEECCCEEEEEEE	58.12	25307156
194	Phosphorylation	FGEETRRVHITHEVS ECCCEEEEEEEEECC	46.40	25307156
196	Phosphorylation	EETRRVHITHEVSSL CCEEEEEEEEECCHH	25.58	29116813
198	Phosphorylation	TRRVHITHEVSSLDT EEEEEEEEECCHHHH	44.58	27732954
200	Phosphorylation	RVHITHEVSSLDTLH EEEEEEECCHHHHHH	41.74	27251275
201	Methylation	VHITHEVSSLDTLHA EEEEEECCHHHHHHH	26.92	-
203	Phosphorylation	ITHEVSSLDTLHALI EEEECCHHHHHHHHH	16.30	24117733
204	Phosphorylation	THEVSSLDTLHALIA EEECCHHHHHHHHHH	17.54	24117733
208	Methylation	SSLDTLHALIAHMFP CHHHHHHHHHHHHCC	38.75	-
211	Phosphorylation	DTLHALIAHMFPQKL HHHHHHHHHHCCCCC	30.23	25849741
212	Phosphorylation	TLHALIAHMFPQKLT HHHHHHHHHCCCCCC	22.28	24117733
215	Phosphorylation	ALIAHMFPQKLTMGM HHHHHHCCCCCCCCC	18.64	25849741
225	Phosphorylation	LTMGMLKSPNTAILI CCCCCCCCCCEEEEE	36.12	18491316
228	Phosphorylation	GMLKSPNTAILIKDE CCCCCCCEEEEEEHH	31.25	18491316
233	Ubiquitination	PNTAILIKDEARNVF CCEEEEEEHHHHHHE	5.17	30230243
234	Phosphorylation	NTAILIKDEARNVFY CEEEEEEHHHHHHEE	26.87	19060867
236	Phosphorylation	AILIKDEARNVFYEL EEEEEHHHHHHEEEE	24.79	24719451
238	Phosphorylation	LIKDEARNVFYELED EEEHHHHHHEEEEHH	32.07	27251275
241	Phosphorylation	DEARNVFYELEDVRD HHHHHHEEEEHHHHC	4.13	-
260	Ubiquitination	SIIKIYRKEPLYAAF CCEEEEECCCCEEEC	6.68	30230243
268	Phosphorylation	EPLYAAFPGSHLTNG CCCEEECCCCCCCCC	21.58	21945579
272	Phosphorylation	AAFPGSHLTNGDLRR EECCCCCCCCCCHHH	22.43	21945579
281	Phosphorylation	NGDLRREMVYASRES CCCHHHHHHHHCCCC	18.01	27251275
298	Phosphorylation	TRRLNNLSPAPHLAS CCCCCCCCCCCCCCC	4.45	-
303	Phosphorylation	NLSPAPHLASGSPPP CCCCCCCCCCCCCCC	20.56	20068231
306	Phosphorylation	PAPHLASGSPPPGLP CCCCCCCCCCCCCCC	25.23	23663014
307	Phosphorylation	APHLASGSPPPGLPS CCCCCCCCCCCCCCC	2.88	-
308	Phosphorylation	PHLASGSPPPGLPSG CCCCCCCCCCCCCCC	26.92	23663014
309	Phosphorylation	HLASGSPPPGLPSGL CCCCCCCCCCCCCCC	27.13	23663014
310	Phosphorylation	LASGSPPPGLPSGLP CCCCCCCCCCCCCCC	7.92	23663014
311	Phosphorylation	ASGSPPPGLPSGLPS CCCCCCCCCCCCCCC	16.12	23663014
317	Phosphorylation	PGLPSGLPSGLQSGS CCCCCCCCCCCCCCC	45.04	23663014
322	Phosphorylation	GLPSGLQSGSPSRSR CCCCCCCCCCCCCCC	24.99	23663014
324	Phosphorylation	PSGLQSGSPSRSRLS CCCCCCCCCCCCCCC	11.52	27251275
329	Methylation	SGSPSRSRLSYAGGR CCCCCCCCCCCCCCC	32.91	-
334	Phosphorylation	RSRLSYAGGRPPSYA CCCCCCCCCCCCHHC	19.12	25884760
336	Methylation	RLSYAGGRPPSYAGS CCCCCCCCCCHHCCC	33.32	-
339	Phosphorylation	YAGGRPPSYAGSPVH CCCCCCCHHCCCHHH	13.51	32142685
340	Phosphorylation	AGGRPPSYAGSPVHH CCCCCCHHCCCHHHH	5.66	32142685
343	Phosphorylation	RPPSYAGSPVHHAAE CCCHHCCCHHHHHHH	23.59	-
345	Phosphorylation	PSYAGSPVHHAAERL CHHCCCHHHHHHHHH	53.35	30266825
346	Phosphorylation	SYAGSPVHHAAERLG HHCCCHHHHHHHHHC	36.80	20886841
362	Phosphorylation	APAAQGVSPSPSAIL CCCCCCCCCCHHHHH	42.23	32142685
364	Phosphorylation	AAQGVSPSPSAILER CCCCCCCCHHHHHHC	47.37	24275569
365	Phosphorylation	AQGVSPSPSAILERR CCCCCCCHHHHHHCC	31.16	25307156
367	Phosphorylation	GVSPSPSAILERRDV CCCCCHHHHHHCCCC	29.31	24275569
368	Phosphorylation	VSPSPSAILERRDVK CCCCHHHHHHCCCCC	48.48	24275569
372	Phosphorylation	PSAILERRDVKPDED HHHHHHCCCCCCCHH	53.02	28985074
373	Methylation	SAILERRDVKPDEDL HHHHHCCCCCCCHHH	56.22	-
375	Phosphorylation	ILERRDVKPDEDLAS HHHCCCCCCCHHHHH	21.07	28985074
380	Phosphorylation	DVKPDEDLASKAGGM CCCCCHHHHHHCCCE	19.22	27251275
385	Phosphorylation	EDLASKAGGMVLVKG HHHHHHCCCEEEEEC	43.54	30266825
387	Phosphorylation	LASKAGGMVLVKGEG HHHHCCCEEEEECCC	24.32	26657352
388	Phosphorylation	ASKAGGMVLVKGEGL HHHCCCEEEEECCCC	33.76	30266825
389	Phosphorylation	SKAGGMVLVKGEGLY HHCCCEEEEECCCCE	23.97	30266825
391	Ubiquitination	AGGMVLVKGEGLYAD CCCEEEEECCCCEEC	7.25	30230243
394	Phosphorylation	MVLVKGEGLYADPYG EEEEECCCCEECCCC	25.97	27362937
396	Phosphorylation	LVKGEGLYADPYGLL EEECCCCEECCCCCC	60.55	-
404	Phosphorylation	ADPYGLLHEGRLSLA ECCCCCCCCCCHHHH	20.82	28985074
406	Phosphorylation	PYGLLHEGRLSLAAA CCCCCCCCCHHHHHH	22.08	-
423	Phosphorylation	DPFAYPGAGGLYKRG CCCCCCCCCCCCCCC	24.09	27499020
428	Ubiquitination	PGAGGLYKRGSVRSL CCCCCCCCCCCCEEC	21.48	30230243
437	Phosphorylation	GSVRSLSTYSAAALQ CCCEECCHHCHHHHH	56.87	32142685
451	Phosphorylation	QSDLEDSLYKAAGGG HHHHHHHHHHHHCCC	28.26	27251275
453	Phosphorylation	DLEDSLYKAAGGGGP HHHHHHHHHHCCCCC	26.44	24114839
458	Phosphorylation	LYKAAGGGGPLYGDG HHHHHCCCCCCCCCC	17.26	24114839
468	Phosphorylation	LYGDGYGFRLPPSSP CCCCCCCCCCCCCCC	42.71	24275569
470	Phosphorylation	GDGYGFRLPPSSPQK CCCCCCCCCCCCCHH	59.97	-
474	Phosphorylation	GFRLPPSSPQKLADV CCCCCCCCCHHHCCC	68.58	32142685
476	Phosphorylation	RLPPSSPQKLADVAA CCCCCCCHHHCCCCC	21.21	25332170
481	Phosphorylation	SPQKLADVAAPPGGP CCHHHCCCCCCCCCC	19.76	28348404
488	Phosphorylation	VAAPPGGPPPPHSPY CCCCCCCCCCCCCCC	44.80	28985074
492	Phosphorylation	PGGPPPPHSPYSGPP CCCCCCCCCCCCCCC	36.08	24076635
493	Phosphorylation	GGPPPPHSPYSGPPS CCCCCCCCCCCCCCC	30.96	24076635
496	Phosphorylation	PPPHSPYSGPPSRGS CCCCCCCCCCCCCCC	27.96	24076635
499	Phosphorylation	HSPYSGPPSRGSPVR CCCCCCCCCCCCCCC	46.95	24076635
500	Phosphorylation	SPYSGPPSRGSPVRQ CCCCCCCCCCCCCCH	38.68	-
501	Methylation	PYSGPPSRGSPVRQS CCCCCCCCCCCCCHH	30.62	-
503	Phosphorylation	SGPPSRGSPVRQSFR CCCCCCCCCCCHHHC	38.31	-
505	Phosphorylation	PPSRGSPVRQSFRKD CCCCCCCCCHHHCCC	46.70	27251275
507	Phosphorylation	SRGSPVRQSFRKDSG CCCCCCCHHHCCCCC	38.80	27251275
508	Phosphorylation	RGSPVRQSFRKDSGS CCCCCCHHHCCCCCC	37.82	27251275
509	Phosphorylation	GSPVRQSFRKDSGSS CCCCCHHHCCCCCCC	18.05	27251275
511	Ubiquitination	PVRQSFRKDSGSSSV CCCHHHCCCCCCCCE	29.37	30230243
513	Phosphorylation	RQSFRKDSGSSSVFA CHHHCCCCCCCCEEE	33.99	32142685
515	Phosphorylation	SFRKDSGSSSVFAES HHCCCCCCCCEEEEC	31.63	-
517	Phosphorylation	RKDSGSSSVFAESPG CCCCCCCCEEEECCC	3.63	-
522	Phosphorylation	SSSVFAESPGGKTRS CCCEEEECCCCCCCC	5.61	-
526	Ubiquitination	FAESPGGKTRSAGSA EEECCCCCCCCCCCC	6.72	30230243
532	Phosphorylation	GKTRSAGSASTAGAP CCCCCCCCCCCCCCC	19.05	28060719
534	Phosphorylation	TRSAGSASTAGAPPS CCCCCCCCCCCCCHH	36.68	28060719
598	Phosphorylation	GSEPETPSEKIEGSN CCCCCCCCHHCCCCC	54.34	-
621	Phosphorylation	CGSGGRSSGATPVSG CCCCCCCCCCCCCCC	33.68	-
624	Phosphorylation	GGRSSGATPVSGPPP CCCCCCCCCCCCCCC	42.57	-
637	Phosphorylation	PPPSASSTPAGQPTA CCCCCCCCCCCCCCH	8.19	-
673	Ubiquitination	GQLQQLRKLQLQNQE HHHHHHHHHHHCCHH	5.90	30230243
693	Phosphorylation	LKRTEAELSMRVSEA HHHHHHHHHHHHHHH	18.03	22985185
714	Phosphorylation	PLQRQRTLVEEERLR HHHHHHHHHHHHHHH	31.60	30266825
716	Phosphorylation	QRQRTLVEEERLRYL HHHHHHHHHHHHHHC	35.00	30266825
719	Methylation	RTLVEEERLRYLNDE HHHHHHHHHHHCCHH	48.48	-
724	Phosphorylation	EERLRYLNDEELITQ HHHHHHCCHHHHHHH	43.35	23532336
729	Phosphorylation	YLNDEELITQQLNDL HCCHHHHHHHHHHHH	28.20	27251275
738	Phosphorylation	QQLNDLEKSVEKIQR HHHHHHHHHHHHHHH	44.94	28188228
747	Phosphorylation	VEKIQRDVSHNHRLV HHHHHHHHCCCCCCC	39.48	23898821
756	Phosphorylation	HNHRLVPGPELEEKA CCCCCCCCHHHHHHH	22.06	25627689
762	Ubiquitination	PGPELEEKALVLKQL CCHHHHHHHHHHHHH	38.47	30230243
767	Ubiquitination	EEKALVLKQLGETLT HHHHHHHHHHHHHHH	60.57	30230243
768	Phosphorylation	EKALVLKQLGETLTE HHHHHHHHHHHHHHH	38.70	24719451
779	Phosphorylation	TLTELKAHFPGLQSK HHHHHHHHCCCHHHC	21.06	22617229
798	Phosphorylation	LRVEVEAVKFLKEEP EEEEEEHHHHHHHCH	21.01	-
809	Phosphorylation	KEEPQRLDGLLKRCR HHCHHHHHHHHHHHH	24.57	-
844	Phosphorylation	PNNLLSQSPKKVTAE CCCCCCCCCCCEEEE	29.62	-
857	Phosphorylation	AETDFNKSVDFEMPP EECCCCCCCCCCCCC	53.12	24275569
859	Phosphorylation	TDFNKSVDFEMPPPS CCCCCCCCCCCCCCC	26.54	30266825
863	Phosphorylation	KSVDFEMPPPSPPLN CCCCCCCCCCCCCCC	26.81	23927012
866	Phosphorylation	DFEMPPPSPPLNLHE CCCCCCCCCCCCHHH	29.27	32142685
867	Phosphorylation	FEMPPPSPPLNLHEL CCCCCCCCCCCHHHC	18.80	23312004
869	Phosphorylation	MPPPSPPLNLHELSG CCCCCCCCCHHHCCC	39.15	30624053
873	Phosphorylation	SPPLNLHELSGPAEG CCCCCHHHCCCCCCC	57.76	28985074
875	Phosphorylation	PLNLHELSGPAEGAS CCCHHHCCCCCCCCC	47.15	23898821
884	Phosphorylation	PAEGASLTPKGGNPT CCCCCCCCCCCCCCC	42.67	25159151
905	Acetylation	GKRSVDKAVSVEAAE CCCCCCCCCCHHHHH	57.60	-
915	Phosphorylation	VEAAERDWEEKRAAL HHHHHCCHHHHHHHH	41.03	28985074
932	Phosphorylation	YSAKDINRLLEETQA CCHHHHHHHHHHHHH	25.93	24719451
939	Phosphorylation	RLLEETQAELLKAIP HHHHHHHHHHHHHCC	44.09	27732954
940	Phosphorylation	LLEETQAELLKAIPD HHHHHHHHHHHHCCC	34.88	27732954
987	Phosphorylation	EPSGRRGSDELTVPR CCCCCCCCCCCCCCC	30.39	20166139
990	Phosphorylation	GRRGSDELTVPRYRT CCCCCCCCCCCCCCC	32.70	25849741
994	Phosphorylation	SDELTVPRYRTEKPS CCCCCCCCCCCCCCC	36.95	25072903
1003	Phosphorylation	RTEKPSKSPPPPPPR CCCCCCCCCCCCCCC	7.24	32142685
1012	Phosphorylation	PPPPPRRSFPSSHGL CCCCCCCCCCCCCCC	17.16	32142685
1020	Phosphorylation	FPSSHGLTTTRTGEV CCCCCCCCCCCCCEE	39.91	28857561
1022	Phosphorylation	SSHGLTTTRTGEVVV CCCCCCCCCCCEEEE	24.96	28857561
1025	Phosphorylation	GLTTTRTGEVVVTSK CCCCCCCCEEEEEEC	38.46	24275569
1026	Phosphorylation	LTTTRTGEVVVTSKK CCCCCCCEEEEEECC	26.85	27732954
1027	Phosphorylation	TTTRTGEVVVTSKKD CCCCCCEEEEEECCC	36.42	25307156
1030	Phosphorylation	RTGEVVVTSKKDSAF CCCEEEEEECCCCCE	43.20	28985074
1034	Phosphorylation	VVVTSKKDSAFIKKA EEEEECCCCCEEHHH	50.36	23312004
1036	Phosphorylation	VTSKKDSAFIKKAES EEECCCCCEEHHHHH	40.19	23312004
1043	Phosphorylation	AFIKKAESEELEVQK CEEHHHHHHCHHCCC	2.52	-
1044	Phosphorylation	FIKKAESEELEVQKP EEHHHHHHCHHCCCC	23.42	-
1052	Phosphorylation	ELEVQKPQVKLRRAV CHHCCCCHHHHHHHH	26.29	24719451
1060	Phosphorylation	VKLRRAVSEVARPAS HHHHHHHHHHCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
264	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
396	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
396	Y	Phosphorylation	Kinase	ALK	Q9UM73	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRCN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRCN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCAR1_HUMAN	BCAR1	physical	14657239
CRK_HUMAN	CRK	physical	14657239
SNP25_HUMAN	SNAP25	physical	10625663
SRC_HUMAN	SRC	physical	17525734
CSK_HUMAN	CSK	physical	17525734
VINEX_HUMAN	SORBS3	physical	18662323
SYPH_HUMAN	SYP	physical	18662323
CKAP5_HUMAN	CKAP5	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRCN1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteomic analysis of synaptosomes from human cerebralcortex."; DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.; J. Proteome Res. 4:306-315(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-859, AND MASSSPECTROMETRY.	15822905 [Abstract]