TMTC4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMTC4_HUMAN
• UniProt AC: Q5T4D3
• Protein Name: Transmembrane and TPR repeat-containing protein 4
• Gene Name: TMTC4
• Organism: Homo sapiens (Human).
• Sequence Length: 741
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAVLDTDLDHILP --CCCCCCCHHHCCC	34.01	26074081
14	Phosphorylation	DLDHILPSSVLPPFW CHHHCCCHHCCCHHH	29.63	26074081
15	Phosphorylation	LDHILPSSVLPPFWA HHHCCCHHCCCHHHH	26.23	26074081
28	Phosphorylation	WAKLVVGSVAIVCFA HHHHHHHCHHHEEEE	9.21	26074081
37	Phosphorylation	AIVCFARSYDGDFVF HHEEEECCCCCCEEC	24.93	26074081
38	Phosphorylation	IVCFARSYDGDFVFD HEEEECCCCCCEECC	20.56	26074081
277	Phosphorylation	LFRMTLLTSGGAGML EEEEEEEECCCCCEE	28.56	-
299	Phosphorylation	GTGPPAFTEVDNPAS CCCCCCCCCCCCHHH	36.89	16094384
322	Phosphorylation	AVNYNYYYSLNAWLL HCCCCEECCHHHHHH	9.05	19901323
473	Phosphorylation	SEEQLFRSALSVCPL CHHHHHHHHHHCCCC	26.65	22210691
540	Phosphorylation	QEAEELLSLAVQIQP HHHHHHHHHHHHHCH	27.23	-
575	Phosphorylation	AAEQSYRTAIKHRRK HHHHHHHHHHHHHHH	25.22	23403867
583	Phosphorylation	AIKHRRKYPDCYYNL HHHHHHHCCCHHHHH	11.51	18083107
587	Phosphorylation	RRKYPDCYYNLGRLY HHHCCCHHHHHHHHH	11.63	18083107
588	Phosphorylation	RKYPDCYYNLGRLYA HHCCCHHHHHHHHHH	15.39	18083107
594	Phosphorylation	YYNLGRLYADLNRHV HHHHHHHHHHHHHHH	9.19	-
671	Phosphorylation	KSQKYKESEALFLKA CCCCHHHHHHHHHHH	24.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMTC4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMTC4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMTC4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CO1A1_HUMAN	COL1A1	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
OS9_HUMAN	OS9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-299, AND MASSSPECTROMETRY.
PubMed: 16094384