KLF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF6_HUMAN
• UniProt AC: Q99612
• Protein Name: Krueppel-like factor 6
• Gene Name: KLF6
• Organism: Homo sapiens (Human).
• Sequence Length: 283
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development..
• Protein Sequence: MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYVSASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLETNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLSSSVTSTPPSSPELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVHRCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRHFRKHTGAKPFKCSHCDRCFSRSDHLALHMKRHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	YLQSEPCYVSASEIK HHHCCCCEEEHHHCC	14.25	27642862
51	Phosphorylation	QSEPCYVSASEIKFD HCCCCEEEHHHCCCC	10.29	29978859
53	Phosphorylation	EPCYVSASEIKFDSQ CCCEEEHHHCCCCCH	32.14	29978859
66	Ubiquitination	SQEDLWTKIILAREK CHHHHHHHHHHHHHH	19.03	2190698
66 (in isoform 2)	Ubiquitination	-	19.03	21906983
66 (in isoform 1)	Ubiquitination	-	19.03	21906983
141	Phosphorylation	LVSSGKLSSSVTSTP EEECCCCCCCCCCCC	24.85	23663014
142	Phosphorylation	VSSGKLSSSVTSTPP EECCCCCCCCCCCCC	38.98	23663014
143	Phosphorylation	SSGKLSSSVTSTPPS ECCCCCCCCCCCCCC	26.49	23663014
145	Phosphorylation	GKLSSSVTSTPPSSP CCCCCCCCCCCCCCC	28.91	23663014
146	Phosphorylation	KLSSSVTSTPPSSPE CCCCCCCCCCCCCCC	36.44	23663014
147	Phosphorylation	LSSSVTSTPPSSPEL CCCCCCCCCCCCCCC	29.83	23663014
150	Phosphorylation	SVTSTPPSSPELSRE CCCCCCCCCCCCCCC	60.78	23663014
151	Phosphorylation	VTSTPPSSPELSREP CCCCCCCCCCCCCCH	28.32	23663014
155	Phosphorylation	PPSSPELSREPSQLW CCCCCCCCCCHHHHC	32.70	23663014
159	Phosphorylation	PELSREPSQLWGCVP CCCCCCHHHHCCCCC	32.90	27251275
171	Phosphorylation	CVPGELPSPGKVRSG CCCCCCCCCCCCCCC	59.93	25850435
192	Phosphorylation	DKGNGDASPDGRRRV CCCCCCCCCCHHCCE	28.41	24719451
209	Acetylation	CHFNGCRKVYTKSSH CEECCCCEEEECCHH	43.61	16230382
213	Acetylation	GCRKVYTKSSHLKAH CCCEEEECCHHHCCC	32.07	61425
218	Acetylation	YTKSSHLKAHQRTHT EECCHHHCCCCCCCC	38.10	61429
223	Phosphorylation	HLKAHQRTHTGEKPY HHCCCCCCCCCCCCE	19.74	-
225	Phosphorylation	KAHQRTHTGEKPYRC CCCCCCCCCCCCEEC	46.56	24719451
228	Acetylation	QRTHTGEKPYRCSWE CCCCCCCCCEECCCC	49.01	30589771
233	Phosphorylation	GEKPYRCSWEGCEWR CCCCEECCCCCCCEE	21.11	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLF6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EHMT2_HUMAN	EHMT2	physical	16189514
APOM_HUMAN	APOM	physical	16169070
TF3C1_HUMAN	GTF3C1	physical	16169070
PNO1_HUMAN	PNO1	physical	16169070
DPOA2_HUMAN	POLA2	physical	16169070
KLF4_HUMAN	KLF4	physical	10802067
SP1_HUMAN	SP1	physical	12433697
NR0B2_HUMAN	NR0B2	physical	17071613
E2F1_HUMAN	E2F1	physical	18521079
HDAC3_HUMAN	HDAC3	physical	15917248
NUFP1_HUMAN	NUFIP1	physical	17636026
FBRL_HUMAN	FBL	physical	17636026
NOP56_HUMAN	NOP56	physical	17636026
SP1_HUMAN	SP1	physical	22169644
A4_HUMAN	APP	physical	21832049
RUNX1_HUMAN	RUNX1	physical	24130502
SP1_HUMAN	SP1	physical	24130502

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613659: Gastric cancer (GASC)
• 176807: Prostate cancer (PC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.