FBRS_HUMAN - dbPTM
FBRS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FBRS_HUMAN
UniProt AC Q9HAH7
Protein Name Probable fibrosin-1
Gene Name FBRS
Organism Homo sapiens (Human).
Sequence Length 460
Subcellular Localization
Protein Description
Protein Sequence MFEKYPGKMEGLFRHNPYTAFPPAVPGLPPGLPPAVSFGSLQGAFQPKSTNPELPPRLGPVPSGLSQKGTQIPDHFRPPLRKPGKWCAMHVRVAYMILRHQEKMKGDSHKLDFRNDLLPCLPGPYGALPPGQELSHPASLFTATGAVHAAANPFTAAPGAHGPFLSPSTHIDPFGRPTSFASLAALSNGAFGGLGSPTFNSGAVFAQKESPGAPPAFASPPDPWGRLHRSPLTFPAWVRPPEAARTPGSDKERPVERREPSITKEEKDRDLPFSRPQLRVSPATPKARAGEEGPRPTKESVRVKEERKEEAAAAAAAAAAAAAAAAAAATGPQGLHLLFERPRPPPFLGPSPPDRCAGFLEPTWLAAPPRLARPPRFYEAGEELTGPGAVAAARLYGLEPAHPLLYSRLAPPPPPAAAPGTPHLLSKTPPGALLGAPPPLVPAPRPSSPPRGPGPARADR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8UbiquitinationMFEKYPGKMEGLFRH
CCCCCCCCCCCCCCC		29.3121890473
8SumoylationMFEKYPGKMEGLFRH
CCCCCCCCCCCCCCC		29.31-
8 (in isoform 1)Ubiquitination-29.31-
8UbiquitinationMFEKYPGKMEGLFRH
CCCCCCCCCCCCCCC		29.31-
8SumoylationMFEKYPGKMEGLFRH
CCCCCCCCCCCCCCC		29.3128112733
68UbiquitinationVPSGLSQKGTQIPDH
CCCCCCCCCCCCCCC		61.6221890473
68UbiquitinationVPSGLSQKGTQIPDH
CCCCCCCCCCCCCCC		61.62-
103AcetylationMILRHQEKMKGDSHK
HHHHCHHHHCCCCCC		39.0619657517
189PhosphorylationSLAALSNGAFGGLGS
HHHHHHCCCCCCCCC		20.93-
190PhosphorylationLAALSNGAFGGLGSP
HHHHHCCCCCCCCCC		12.26-
193PhosphorylationLSNGAFGGLGSPTFN
HHCCCCCCCCCCCCC		22.0217287340
196PhosphorylationGAFGGLGSPTFNSGA
CCCCCCCCCCCCCCC		26.3017287340
210PhosphorylationAVFAQKESPGAPPAF
CEEEECCCCCCCCCC		35.3525850435
219PhosphorylationGAPPAFASPPDPWGR
CCCCCCCCCCCCCCC		30.4325159151
229Asymmetric dimethylarginineDPWGRLHRSPLTFPA
CCCCCCCCCCCCCCC		44.56-
229MethylationDPWGRLHRSPLTFPA
CCCCCCCCCCCCCCC		44.5624129315
230PhosphorylationPWGRLHRSPLTFPAW
CCCCCCCCCCCCCCC		17.3220873877
233PhosphorylationRLHRSPLTFPAWVRP
CCCCCCCCCCCCCCC		30.8429978859
237PhosphorylationSPLTFPAWVRPPEAA
CCCCCCCCCCCHHHH		6.21-
239Asymmetric dimethylarginineLTFPAWVRPPEAART
CCCCCCCCCHHHHCC		30.29-
239MethylationLTFPAWVRPPEAART
CCCCCCCCCHHHHCC		30.2924129315
244PhosphorylationWVRPPEAARTPGSDK
CCCCHHHHCCCCCCC		17.76-
246PhosphorylationRPPEAARTPGSDKER
CCHHHHCCCCCCCCC		27.5529496963
249PhosphorylationEAARTPGSDKERPVE
HHHCCCCCCCCCCCC		46.8727251275
261PhosphorylationPVERREPSITKEEKD
CCCCCCCCCCHHHHC		37.8328102081
272SumoylationEEKDRDLPFSRPQLR
HHHCCCCCCCCCCCE		29.47-
274PhosphorylationKDRDLPFSRPQLRVS
HCCCCCCCCCCCEEC		40.9021712546
281PhosphorylationSRPQLRVSPATPKAR
CCCCCEECCCCCCCC		11.4630266825
284PhosphorylationQLRVSPATPKARAGE
CCEECCCCCCCCCCC		28.8030266825
288MethylationSPATPKARAGEEGPR
CCCCCCCCCCCCCCC		49.61-
295MethylationRAGEEGPRPTKESVR
CCCCCCCCCCHHHCC		63.48-
309PhosphorylationRVKEERKEEAAAAAA
CCHHHHHHHHHHHHH		60.12-
330PhosphorylationAAAAAAATGPQGLHL
HHHHHHHHCCCCEEH		44.6727251275
333PhosphorylationAAAATGPQGLHLLFE
HHHHHCCCCEEHHCC		69.31-
351PhosphorylationPPPFLGPSPPDRCAG
CCCCCCCCCCCCCCC		47.4625849741
370MethylationTWLAAPPRLARPPRF
CCCCCCCHHCCCCCC		39.66-
373MethylationAAPPRLARPPRFYEA
CCCCHHCCCCCCCCC		46.47-
376MethylationPRLARPPRFYEAGEE
CHHCCCCCCCCCCCC		49.84-
394MethylationPGAVAAARLYGLEPA
HHHHHHHHHHCCCCC		24.58-
396PhosphorylationAVAAARLYGLEPAHP
HHHHHHHHCCCCCCC		17.70-
406PhosphorylationEPAHPLLYSRLAPPP
CCCCCCHHHCCCCCC		10.22-
407PhosphorylationPAHPLLYSRLAPPPP
CCCCCHHHCCCCCCC		22.3124719451
408MethylationAHPLLYSRLAPPPPP
CCCCHHHCCCCCCCC		22.70-
421PhosphorylationPPAAAPGTPHLLSKT
CCCCCCCCCCCCCCC		13.3829978859
426PhosphorylationPGTPHLLSKTPPGAL
CCCCCCCCCCCCCCC		40.6229978859
428PhosphorylationTPHLLSKTPPGALLG
CCCCCCCCCCCCCCC		31.1929255136
447PhosphorylationLVPAPRPSSPPRGPG
CCCCCCCCCCCCCCC		57.6725159151
448PhosphorylationVPAPRPSSPPRGPGP
CCCCCCCCCCCCCCC		41.4225159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FBRS_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FBRS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FBRS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MARF1_HUMANKIAA0430physical
27173435
PCGF3_HUMANPCGF3physical
27173435
Drug and Disease Associations
Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FBRS_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281 AND THR-284, ANDMASS SPECTROMETRY.

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