PCGF3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCGF3_HUMAN
• UniProt AC: Q3KNV8
• Protein Name: Polycomb group RING finger protein 3
• Gene Name: PCGF3
• Organism: Homo sapiens (Human).
• Sequence Length: 242
• Subcellular Localization: Nucleus . Nucleus, nucleoplasm . Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
• Protein Description: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. [PubMed: 26151332 Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity]
• Protein Sequence: MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGETCSAKQHLDSHRNGETKADDSSNKEAAEEKPEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	CLHTFCRSCLVKYLE HHHHHHHHHHHHHHH	17.00	24719451
73	Phosphorylation	QYIGHDRTMQDIVYK HHCCCCCCHHHHHHH	25.82	25690035
79	Phosphorylation	RTMQDIVYKLVPGLQ CCHHHHHHHHCCCHH	10.03	22817900
99	Ubiquitination	KQREFYHKLGMEVPG HHHHHHHHCCCCCCC	35.04	-
104 (in isoform 2)	Ubiquitination	-	4.82	-
116	Acetylation	KGETCSAKQHLDSHR CCCCCCCHHHHHHCC	23.20	7670035
116	Ubiquitination	KGETCSAKQHLDSHR CCCCCCCHHHHHHCC	23.20	-
132	Phosphorylation	GETKADDSSNKEAAE CCCCCCCCCCHHHHH	36.04	24260401
148	Phosphorylation	KPEEDNDYHRSDEQV CCCCCCCCCCCHHHE	12.85	22817900
165	Ubiquitination	CLECNSSKLRGLKRK EEECCCHHHCCCCHH	41.86	-
212	Ubiquitination	CNEEILGKDHTLKFV CCHHHCCCCCEEEEE	42.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCGF3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCGF3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCGF3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RING2_HUMAN	RNF2	physical	22325352
RING1_HUMAN	RING1	physical	22325352
RYBP_HUMAN	RYBP	physical	22325352
YAF2_HUMAN	YAF2	physical	22325352
CBX4_HUMAN	CBX4	physical	22325352
MGAP_HUMAN	MGA	physical	22325352
BCORL_HUMAN	BCORL1	physical	22325352
KDM2B_HUMAN	KDM2B	physical	22325352
UBP7_HUMAN	USP7	physical	22325352
AUTS2_HUMAN	AUTS2	physical	22325352
FBRS_HUMAN	FBRS	physical	22325352
FBSL_HUMAN	FBRSL1	physical	22325352
CSK21_HUMAN	CSNK2A1	physical	22325352
CSK22_HUMAN	CSNK2A2	physical	22325352
CSK2B_HUMAN	CSNK2B	physical	22325352
BCOR_HUMAN	BCOR	physical	23523425
BCORL_HUMAN	BCORL1	physical	23523425
RING2_HUMAN	RNF2	physical	22493164
BMI1_HUMAN	BMI1	physical	22493164
RING1_HUMAN	RING1	physical	22493164
BCOR_HUMAN	BCOR	physical	25416956
RING2_HUMAN	RNF2	physical	26151332
PCGF3_HUMAN	PCGF3	physical	26151332
UB2D3_HUMAN	UBE2D3	physical	26151332
NISCH_HUMAN	NISCH	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.